Abstract:
:Publicly funded cancer medicines listed on the New Zealand Pharmaceutical Schedule were compared with those listed on the Australian Pharmaceutical Benefits Scheme. To quantify the health gains offered by the cancer medicines funded in Australia but not in New Zealand, clinical trial data reporting median progression-free survival (PFS) and overall survival (OS) were sought. The differences in the median PFS and OS for the unfunded medicines, relative to the comparator medicine funded in NZ, were then assessed against the American Society of Clinical Oncology Cancer Research Committee (ASCO-CRC) recommended targets for clinically meaningful health gains. Our analysis confirms that, whilst New Zealand funds fewer cancer medicines than Australia, most of the additional medicines funded in Australia do not deliver clinically meaningful health gains as defined by the ASCO-CRC guidance. This suggests that New Zealand is not missing substantive opportunities for improvements to New Zealand's cancer survival rates through additional medicines funding. A policy of funding more new cancer medicines in order to achieve numerical parity with Australia or other countries would not result in substantive health improvement and would cost significantly more, and investing the millions of dollars needed to achieve funding parity with other countries would not represent good value for money in terms of delivering the best health outcomes for all New Zealanders, rather selective funding of new medicines that demonstrate clear clinical benefit and that are cost-effective and affordable is the sensible approach.
journal_name
Semin Oncoljournal_title
Seminars in oncologyauthors
Evans J,Laking G,Strother M,Wang T,Metcalfe S,Blick G,Pauls R,Crausaz Sdoi
10.1053/j.seminoncol.2016.10.004subject
Has Abstractpub_date
2016-12-01 00:00:00pages
625-637issue
6eissn
0093-7754issn
1532-8708pii
S0093-7754(16)30058-6journal_volume
43pub_type
杂志文章,评审abstract::The results of recent clinical trials have shown that docetaxel (Taxotere; Rhône-Poulenc Rorer, Antony, France), like paclitaxel (Taxol; Bristol-Myers Squibb Oncology, Princeton, NJ), has high levels of activity in patients with anthracycline-resistant breast cancer. Agents that are at least partially non-cross-resist...
journal_title:Seminars in oncology
pub_type: 杂志文章,评审
doi:
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journal_title:Seminars in oncology
pub_type: 杂志文章,评审
doi:
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journal_title:Seminars in oncology
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doi:
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journal_title:Seminars in oncology
pub_type: 杂志文章,评审
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journal_title:Seminars in oncology
pub_type: 杂志文章,评审
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journal_title:Seminars in oncology
pub_type: 临床试验,杂志文章,多中心研究
doi:
更新日期:1996-12-01 00:00:00
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journal_title:Seminars in oncology
pub_type: 杂志文章
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journal_title:Seminars in oncology
pub_type: 杂志文章,评审
doi:
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journal_title:Seminars in oncology
pub_type: 杂志文章,评审
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更新日期:2009-08-01 00:00:00
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journal_title:Seminars in oncology
pub_type: 杂志文章
doi:
更新日期:2003-06-01 00:00:00
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journal_title:Seminars in oncology
pub_type: 杂志文章,评审
doi:
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journal_title:Seminars in oncology
pub_type: 杂志文章,评审
doi:10.1053/j.seminoncol.2009.05.002
更新日期:2009-08-01 00:00:00
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journal_title:Seminars in oncology
pub_type: 临床试验,杂志文章
doi:
更新日期:1996-12-01 00:00:00
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journal_title:Seminars in oncology
pub_type: 杂志文章,评审
doi:
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journal_title:Seminars in oncology
pub_type: 杂志文章
doi:10.1053/j.seminoncol.2009.07.005
更新日期:2009-10-01 00:00:00
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journal_title:Seminars in oncology
pub_type: 杂志文章
doi:10.1053/j.seminoncol.2007.09.004
更新日期:2007-12-01 00:00:00
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journal_title:Seminars in oncology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
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journal_title:Seminars in oncology
pub_type: 杂志文章
doi:10.1053/sonc.2002.30152
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journal_title:Seminars in oncology
pub_type: 杂志文章,评审
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journal_title:Seminars in oncology
pub_type: 杂志文章,评审
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更新日期:2014-04-01 00:00:00
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journal_title:Seminars in oncology
pub_type: 杂志文章,评审
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journal_title:Seminars in oncology
pub_type: 杂志文章,评审
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更新日期:2016-08-01 00:00:00
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journal_title:Seminars in oncology
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journal_title:Seminars in oncology
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abstract::The combination of gemcitabine and docetaxel exhibits good activity in the treatment of advanced breast cancer. Phase II trial response rates using 21- or 28-day schedules have ranged from 36% to 79% in patient populations with varying degrees of pretreatment. In studies of extensively pretreated anthracycline-resista...
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