Controlling Tumor Progression with Cyclophosphamide, Vincristine, and Dacarbazine Treatment Improves Survival in Patients with Metastatic and Unresectable Malignant Pheochromocytomas/Paragangliomas.

abstract：:Cancer progression is driven by genome instability incurred rearrangements such as transmembrane protease, serine 2 (TMPRSS2)/v-ets erythroblastosis virus E26 oncogene (ERG) that could possibly turn some of the tumor suppressor micro-RNAs into pro-oncogenic ones. Previously, we found dualistic miR-204 effects, acting ...

journal_title：Hormones & cancer

authors： Todorova K,Metodiev MV,Metodieva G,Mincheff M,Fernández N,Hayrabedyan S

更新日期：2017-02-01 00:00:00

abstract：:Adjuvant glucocorticoid treatment is routinely used in the treatment of ovarian cancer to mitigate the undesirable side effects of chemotherapy, thereby enhancing tolerability to higher cytotoxic drug doses and frequency of treatment cycles. However, in vitro and preclinical in vivo and ex vivo studies indicate that g...

journal_title：Hormones & cancer

authors： Djedovic V,Lee YY,Kollara A,May T,Brown TJ

更新日期：2018-04-01 00:00:00

abstract：:Thyroid hormone status has long been implicated in cancer development. Here we investigated the role of thyroxine (T4) in colorectal cancer cell lines HCT 116 (APC wild type) and HT-29 (APC mutant), as well as the primary cultures of cancer cells derived from patients. Cell proliferation was evaluated with standard as...

journal_title：Hormones & cancer

authors： Lee YS,Chin YT,Shih YJ,Nana AW,Chen YR,Wu HC,Yang YSH,Lin HY,Davis PJ

更新日期：2018-06-01 00:00:00

abstract：:Breast and prostate cancers are malignancies in which steroid hormones drive cellular proliferation. Over the past century, this understanding has led to successful treatment strategies aimed to inhibit hormone-mediated tumor growth. Nonetheless, disease relapse and progression still pose significant clinical problems...

journal_title：Hormones & cancer

authors： Capper CP,Rae JM,Auchus RJ

更新日期：2016-06-01 00:00:00

abstract：:We previously reported that an accelerated decline in circulating testosterone level is associated with a higher risk of prostate cancer (PCa). This study is to examine whether testosterone change rate is related to serum prostate-specific antigen (PSA) concentration among PCa-free men. Longitudinal data were derived ...

journal_title：Hormones & cancer

authors： Wang K,Chen X,Cheng TD,Qiu P,Bird VY,Prosperi M

更新日期：2019-12-01 00:00:00

abstract：:Von Hippel-Lindau (VHL) syndrome is an inherited cancer syndrome in which 8-17 % of germline mutation carriers develop pancreatic neuroendocrine tumors (PNETs). There is limited data on prognostic markers for PNETs other than Ki-67, which is included in the World Health Organization classification system. Recently, sp...

journal_title：Hormones & cancer

authors： Weisbrod AB,Zhang L,Jain M,Barak S,Quezado MM,Kebebew E

更新日期：2013-06-01 00:00:00

abstract：:Oestrogen receptor alpha (ERα) is a ligand-dependent transcription factor that mediates oestrogen effects in hormone-responsive cells. Following oestrogenic activation, ERα directly regulates the transcription of target genes via DNA binding. MicroRNAs (miRNAs) represent a class of small noncoding RNAs that function a...

journal_title：Hormones & cancer

authors： Ferraro L,Ravo M,Nassa G,Tarallo R,De Filippo MR,Giurato G,Cirillo F,Stellato C,Silvestro S,Cantarella C,Rizzo F,Cimino D,Friard O,Biglia N,De Bortoli M,Cicatiello L,Nola E,Weisz A

更新日期：2012-06-01 00:00:00

abstract：:CYP19A1, also called aromatase, is a key enzyme for converting androgens to estrogens of estrogen synthesis. Elevated serum estrogen and high expression levels of estrogen-related proteins are found in cholangiocarcinoma (CCA; bile duct cancer). However, the expression of CYP19A1 in relation to estrogen-related protei...

journal_title：Hormones & cancer

authors： Kaewlert W,Sakonsinsiri C,Namwat N,Sawanyawisuth K,Ungarreevittaya P,Khuntikeo N,Armartmuntree N,Thanan R

更新日期：2018-12-01 00:00:00

abstract：:Endometrial cancer is the fourth most common malignancy among women and is a major cause of morbidity contributing to approximately 8,200 annual deaths in the USA. Despite advances to the understanding of endometrial cancer, novel interventions for the disease are necessary given that many tumors become refractory to ...

journal_title：Hormones & cancer

authors： Ma JJ,Monsivais D,Dyson MT,Coon JS,Malpani S,Ono M,Zhao H,Xin H,Pavone ME,Kim JJ,Chakravarti D,Bulun SE

更新日期：2013-12-01 00:00:00

abstract：:In clinical practice, few prostate cancer (PCa) patients are associated with metabolic syndrome (MetS), while few others acquire MetS during treatment. Whether the treatment of PCa increases the occurrence of MetS remains to be confirmed. This study reviewed the changes in MetS patients before and after PCa treatment ...

journal_title：Hormones & cancer

authors： Chen Z,Deng J,Yan Y,Li M,Chen C,Chen C,Zhao S,Song T,Liu T,Wen X,Yao Y

更新日期：2018-08-01 00:00:00

abstract：:The androgen receptor (AR) has context-dependent roles in breast cancer growth and progression. Overall, high tumor AR levels predict a favorable patient outcome, but several studies have established a tumor promotional role for AR, particularly in supporting the growth of estrogen receptor positive (ER-positive) brea...

journal_title：Hormones & cancer

authors： Wellberg EA,Checkley LA,Giles ED,Johnson SJ,Oljira R,Wahdan-Alaswad R,Foright RM,Dooley G,Edgerton SM,Jindal S,Johnson GC,Richer JK,Kabos P,Thor AD,Schedin P,MacLean PS,Anderson SM

更新日期：2017-12-01 00:00:00

abstract：:Endometrial cancer is the most common gynecological cancer in the developed world, and it is one of the few cancer types that is becoming more prevalent and leading to more deaths in the USA each year. The majority of endometrial tumors are considered to be hormonally driven, where estrogen signaling through estrogen ...

journal_title：Hormones & cancer

authors： Rodriguez AC,Blanchard Z,Maurer KA,Gertz J

更新日期：2019-06-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor best known for its ability to mediate the effects of environmental toxins such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin), polycyclic aromatic hydrocarbons (PAHs), benzene, and polychlorinated biphenyls (PCBs) through the initi...

journal_title：Hormones & cancer

authors： Formosa R,Vassallo J

更新日期：2017-08-01 00:00:00

abstract：:Castration-resistant prostate cancer (CRPC) is an androgen receptor (AR)-dependent disease expected to cause the death of more than 27,000 Americans in 2015. There are only a few available treatments for CRPC, making the discovery of new drugs an urgent need. We report that CUDC-101 (an inhibitor od HER2/NEU, EGFR and...

journal_title：Hormones & cancer

authors： Sun H,Mediwala SN,Szafran AT,Mancini MA,Marcelli M

更新日期：2016-06-01 00:00:00

abstract：:Tetraiodothyroacetic acid (tetrac) and its nanoparticle formulation (Tetrac NP) act at an integrin cell surface receptor to inhibit tumor cell proliferation and tumor-related angiogenesis. Human pancreatic cancer cell (PANC-1 and MPanc96) xenografts were established in nude mice, and the effects of tetrac versus Tetra...

journal_title：Hormones & cancer

authors： Yalcin M,Lin HY,Sudha T,Bharali DJ,Meng R,Tang HY,Davis FB,Stain SC,Davis PJ,Mousa SA

更新日期：2013-06-01 00:00:00

abstract：:Lymphangioleiomyomatosis (LAM) is a female-predominant lung disease that can lead to respiratory failure. LAM cells typically have inactivating tuberous sclerosis 2 (TSC2) mutations, leading to mTORC1 hyperactivation. The gender specificity of LAM suggests that female hormones contribute to disease progression. Clinic...

journal_title：Hormones & cancer

authors： Sun Y,Zhang E,Lao T,Pereira AM,Li C,Xiong L,Morrison T,Haley KJ,Zhou X,Yu JJ

更新日期：2014-10-01 00:00:00

abstract：:Ovarian cancer is the leading cause of death among gynecological malignancies. Chemotherapy alone is not sufficient to achieve long-term survival of the patient with advanced stage ovarian cancer. Although cancer immune therapy has long been expected as a new modality for ovarian cancer, very few trials have been clin...

journal_title：Hormones & cancer

authors： Mandai M,Hamanishi J,Abiko K,Matsumura N,Baba T,Yoshioka Y,Konishi I

更新日期：2010-12-01 00:00:00

abstract：:The molecular pathogenesis of sporadic parathyroid adenomas is incompletely understood. The possible role of cyclin-dependent kinase inhibitor (CDKI) genes was raised by recognition of cyclin D1 as a parathyroid oncogene, identification of rare germline mutations in CDKI genes in patients with multiple endocrine neopl...

journal_title：Hormones & cancer

authors： Costa-Guda J,Soong CP,Parekh VI,Agarwal SK,Arnold A

更新日期：2013-10-01 00:00:00

abstract：:Adrenocortical carcinoma (ACC) is a rare and complex disease associated with a high mortality rate. Despite intensive translational and clinical research, prognosis remains poor. Over the past decade, a significant effort has been made to develop multinational, collaborative studies to better understand the pathogenes...

journal_title：Hormones & cancer

authors： Hoff AO,Berruti A

更新日期：2016-02-01 00:00:00

abstract：:The authors conducted a cross-sectional study to investigate the associations of fat, fiber, and carbohydrate intake with endogenous estrogen, androgen, and insulin-like growth factor (IGF) levels among 595 premenopausal women. Overall, no significant associations were found between dietary intake of these macronutrie...

journal_title：Hormones & cancer

authors： Cui X,Rosner B,Willett WC,Hankinson SE

更新日期：2010-10-01 00:00:00

abstract：:The prostate is a luminal secretory tissue whose function is regulated by male sex hormones. Castration produces involution of the prostate to a reversible basal state, and as the majority of prostate cancers also have a luminal phenotype, drug-induced castration is a front line therapy. It has therefore been assumed ...

journal_title：Hormones & cancer

authors： Maitland NJ,Frame FM,Polson ES,Lewis JL,Collins AT

更新日期：2011-02-01 00:00:00

abstract：:The anti-diabetic drug metformin (1,1-dimethylbiguanide hydrochloride) reduces both the incidence and mortality of several types of cancer. Metformin has been shown to selectively kill cancer stem cells, and triple-negative breast cancer (TNBC) cell lines are more sensitive to the effects of metformin as compared to l...

journal_title：Hormones & cancer

authors： Wahdan-Alaswad RS,Cochrane DR,Spoelstra NS,Howe EN,Edgerton SM,Anderson SM,Thor AD,Richer JK

更新日期：2014-12-01 00:00:00

abstract：:Consumption of methylxanthine alkaloids appears to induce activities by antagonizing adenosine receptors, implicated in breast cancer behavior in vitro. Our goal was to evaluate expression of genes for methylxanthine receptors and metabolizing enzymes to assess risk of breast carcinoma recurrence. Clinical outcomes, e...

journal_title：Hormones & cancer

authors： Wittliff JL,Sereff SB,Daniels MW

更新日期：2017-12-01 00:00:00

abstract：:Recent observations connected DNA cytosine deaminase APOBEC3B to the genetic evolution of breast cancer. We addressed whether APOBEC3B is associated with breast cancer clinical outcomes. APOBEC3B messenger RNA (mRNA) levels were related in 1,491 primary breast cancers to disease-free (DFS), metastasis-free (MFS), and ...

journal_title：Hormones & cancer

authors： Sieuwerts AM,Willis S,Burns MB,Look MP,Meijer-Van Gelder ME,Schlicker A,Heideman MR,Jacobs H,Wessels L,Leyland-Jones B,Gray KP,Foekens JA,Harris RS,Martens JW

更新日期：2014-12-01 00:00:00

abstract：:Breast cancer survivors are at an increased risk of second primary cancers, and the risk factors for the latter may have clinical significance. The aims of our study were to evaluate the incidences and risk factors of second primary female genital cancers (corpus uteri, cervix uteri plus ovary) in a large cohort of br...

journal_title：Hormones & cancer

authors： Li Z,Wu Q,Song J,Zhang Y,Zhu S,Sun S

更新日期：2018-06-01 00:00:00

abstract：:Oral contraceptive use is a well-established risk factor for breast cancer and is common among reproductive-aged women in the USA. Its relationship with less common, more aggressive, molecular subtypes is less clear. A population-based case-case analysis was conducted comparing three less common molecular subtypes to ...

journal_title：Hormones & cancer

authors： Lorona NC,Cook LS,Tang MC,Hill DA,Wiggins CL,Li CI

更新日期：2019-06-01 00:00:00

abstract：:Mitotic checkpoint is a fundamental mechanism involved in fidelity mitotic chromosome segregation, and its alteration results in progression of human malignancies. In this study, we examined expression profiles of seven mitotic checkpoint genes in 20 breast carcinomas using microarray analysis. Results demonstrated th...

journal_title：Hormones & cancer

authors： Takagi K,Miki Y,Shibahara Y,Nakamura Y,Ebata A,Watanabe M,Ishida T,Sasano H,Suzuki T

更新日期：2013-04-01 00:00:00

abstract：:Silent corticotrophins adenomas (SCAs) are clinically silent and non-secreting but immunostain positively for ACTH. We hypothesize that SCAs comprise both corticotroph and gonadotroph characteristics. Cohort analysis from 1994-2008 with follow-up time ranging from 1-15 years in a tertiary referral center. We compared ...

journal_title：Hormones & cancer

authors： Cooper O,Ben-Shlomo A,Bonert V,Bannykh S,Mirocha J,Melmed S

更新日期：2010-04-01 00:00:00

abstract：:The pathological diagnosis of adrenocortical carcinoma (ACC) is still challenging for its rarity and the presence of special variants (pediatric, oncocytic, myxoid, and sarcomatoid). It is based on the recognition at light microscopy of at least three among nine morphological parameters, according to the Weiss scoring...

journal_title：Hormones & cancer

authors： Papotti M,Libè R,Duregon E,Volante M,Bertherat J,Tissier F

更新日期：2011-12-01 00:00:00

abstract：:Differential utilization of cancer screening between populations could lead to changes in cancer disparities. Evaluating incidence rates trends is one means of monitoring these disparities. Using Surveillance, Epidemiology, and End Results data, we compared annual percent changes (APC) in age-adjusted incidence rates ...

journal_title：Hormones & cancer

authors： McDougall JA,Li CI

更新日期：2010-02-01 00:00:00