Abstract:
:Langerhans cell histiocytosis (LCH) is a proliferative disease of CD1a+ /CD207+ dendritic cells. Recurrent BRAFV600E and MAP2K1 mutations have been reported in LCH. To investigate the relationship among the mutation, clinical findings, and differentiation status of LCH, respectively, we studied 97 cases of LCH by using Sanger sequencing and immunohistochemistry. The mutually exclusive BRAFV600E and MAP2K1 mutation rates were 32% and 17.5%, respectively. All MAP2K1 mutations were missense mutations without any in-frame deletions; 2 new recurrent missense mutations (ie, p.E38K and p.P105S) were also found. More BRAFV600E and MAP2K1 mutations occurred in children compared with those in adult patients (P = .001), and BRAF mutation was correlated with relapse (P = .009). To the differentiation-related markers, the BRAF/MAP2K1-mut LCH expressed CD14 but rarely expressed CD83 or CD86 (P < .001). On the contrary, BRAF/MAP2K1-wt LCH cells rarely expressed CD14 but expressed CD86, and some also expressed CD83 (P < .001). This indicated that the BRAF/MAP2K1-mut LCH cells had a more immature state than BRAF/MAP2K1-wt LCH cells. Moreover, we also found the BRAFV600E and MAP2K1 mutations were significantly associated with pERK expression (P < .001). Therefore, the RAS/RAF/MEK/ERK pathway might play a more important role in children than in adult patients with LCH.
journal_name
Hematol Oncoljournal_title
Hematological oncologyauthors
Zeng K,Ohshima K,Liu Y,Zhang W,Wang L,Fan L,Li M,Li X,Wang Z,Guo S,Yan Q,Guo Ydoi
10.1002/hon.2344subject
Has Abstractpub_date
2017-12-01 00:00:00pages
845-851issue
4eissn
0278-0232issn
1099-1069journal_volume
35pub_type
杂志文章abstract::Acute kidney injury (AKI) is one of the complications of hematopoietic stem cell transplantation and is associated with increased mortality. N-acetylcysteine (NAC) is a thiol compound with antioxidant and vasodilatory properties that has been investigated for the prevention of AKI in several clinical settings. In the ...
journal_title:Hematological oncology
pub_type: 杂志文章,随机对照试验
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journal_title:Hematological oncology
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journal_title:Hematological oncology
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abstract::This paper presents a new analysis of aspects of the descriptive epidemiology of multiple myeloma (MM) for parts of the U.K., 1984-1993. It provides no indication for geographical heterogeneity, nor is there evidence of a decline in rates over the decade. There is, however, evidence that cancer registration inflates M...
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journal_title:Hematological oncology
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journal_title:Hematological oncology
pub_type: 杂志文章,评审
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journal_title:Hematological oncology
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journal_title:Hematological oncology
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journal_title:Hematological oncology
pub_type: 杂志文章
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更新日期:1989-09-01 00:00:00
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journal_title:Hematological oncology
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journal_title:Hematological oncology
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journal_title:Hematological oncology
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journal_title:Hematological oncology
pub_type: 杂志文章,评审
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journal_title:Hematological oncology
pub_type: 临床试验,杂志文章
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journal_title:Hematological oncology
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journal_title:Hematological oncology
pub_type: 杂志文章
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更新日期:2017-09-01 00:00:00
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更新日期:1984-04-01 00:00:00