Abstract:
:Acute kidney injury (AKI) is one of the complications of hematopoietic stem cell transplantation and is associated with increased mortality. N-acetylcysteine (NAC) is a thiol compound with antioxidant and vasodilatory properties that has been investigated for the prevention of AKI in several clinical settings. In the present study, we evaluated the effects of intravenous NAC on the prevention of AKI in allogeneic hematopoietic stem cell transplantation patients. A double-blind randomized placebo-controlled trial was conducted, and 80 patients were recruited to receive 100 mg/kg/day NAC or placebo as intermittent intravenous infusion from day -6 to day +15. AKI was determined on the basis of the Risk-Injury-Failure-Loss-End-stage renal disease and AKI Network criteria as the primary outcome. We assessed urine neutrophil gelatinase-associated lipocalin (uNGAL) on days -6, -3, +3, +9 and +15 as the secondary outcome. Moreover, transplant-related outcomes and NAC adverse reactions were evaluated during the study period. Statistical analysis was performed using appropriate parametric and non-parametric methods including Kaplan-Meier for AKI and generalized estimating equation for uNGAL. At the end of the trial, data from 72 patients were analysed (NAC: 33 patients and placebo: 39 patients). Participants of each group were not different considering baseline characteristics. AKI was observed in 18% of NAC recipients and 15% of placebo group patients, and the occurrence pattern was not significantly different (p = 0.73). Moreover, no significant difference was observed between groups for uNGAL measures (p = 0.10). Transplant-related outcomes were similar for both groups, and all patients had successful engraftment. Three patients did not tolerate NAC because of abdominal pain, shortness of breath and rash with pruritus and were dropped from the intervention group before transplantation. However, the frequency of adverse reactions was not significantly different between groups. In conclusion, our findings could not show any clinical benefits from high-dose NAC particularly for AKI prevention in allogeneic hematopoietic stem cell transplantation patients.
journal_name
Hematol Oncoljournal_title
Hematological oncologyauthors
Ataei S,Hadjibabaie M,Moslehi A,Taghizadeh-Ghehi M,Ashouri A,Amini E,Gholami K,Hayatshahi A,Vaezi M,Ghavamzadeh Adoi
10.1002/hon.2141subject
Has Abstractpub_date
2015-06-01 00:00:00pages
67-74issue
2eissn
0278-0232issn
1099-1069journal_volume
33pub_type
杂志文章,随机对照试验abstract::Follicular lymphoma is the most common indolent non-Hodgkin lymphoma. Survival has improved over the last several decades, mainly because of the incorporation of the anti-CD20 antibody rituximab into preexisting or rediscovered agents. The disease has a relapsing and remitting pattern, coupled with a risk of transform...
journal_title:Hematological oncology
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journal_title:Hematological oncology
pub_type: 杂志文章,meta分析
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abstract::Twenty-three patients (16 adults) failing their first or subsequent (n = 8) intensive treatment for de novo acute lymphoblastic leukemia (ALL) and chronic myeloid leukemia lymphoid blast phase (n = 2) were managed with protocol POG 8201, originally introduced in relapsed ALL of childhood. In this programme, a four-dru...
journal_title:Hematological oncology
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doi:10.1002/hon.2900100206
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journal_title:Hematological oncology
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journal_title:Hematological oncology
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journal_title:Hematological oncology
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journal_title:Hematological oncology
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doi:10.1002/hon.2900090608
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abstract::To extend the clinical-pathologic description of small cleaved cell lymphoma (SCCL), we reviewed the records of 106 patients with SCCL who were treated in accordance with a policy of watchful waiting and palliative therapy. Median age was 58 years. A pure diffuse pattern was seen in only 16 per cent of cases. Stage II...
journal_title:Hematological oncology
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pub_type: 杂志文章,多中心研究
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journal_title:Hematological oncology
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journal_title:Hematological oncology
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journal_title:Hematological oncology
pub_type: 杂志文章
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journal_title:Hematological oncology
pub_type: 杂志文章
doi:10.1002/hon.2900010105
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journal_title:Hematological oncology
pub_type: 杂志文章
doi:10.1002/hon.2500
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journal_title:Hematological oncology
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journal_title:Hematological oncology
pub_type: 杂志文章,评审
doi:10.1002/(sici)1099-1069(199909)17:3<91::aid-hon643
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journal_title:Hematological oncology
pub_type: 杂志文章
doi:10.1002/hon.2900100504
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journal_title:Hematological oncology
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journal_title:Hematological oncology
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journal_title:Hematological oncology
pub_type: 临床试验,杂志文章
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journal_title:Hematological oncology
pub_type: 杂志文章
doi:10.1002/hon.2900080205
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journal_title:Hematological oncology
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journal_title:Hematological oncology
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