Abstract:
BACKGROUND:Alcohol use disorders (AUD) is a phase of alcohol misuse in which the drinker consumes excessive amount of alcohol and have a continuous urge to consume alcohol which may lead to various health complications. The current methods of alcohol use disorders diagnosis such as questionnaires and some biomarkers lack specificity and sensitivity. Metabolomics is a novel scientific field which may provide a novel method for the diagnosis of AUD by using a sensitive and specific technique such as nuclear magnetic resonance (NMR). METHODS:A cross sectional study was conducted on three groups: individuals with alcohol use disorders (n=30), social drinkers (n=54) and alcohol-naive controls (n=60). 1H NMR-based metabolomics was used to obtain the metabolic profiles of plasma samples. Data were processed by multivariate principal component analysis (PCA) and orthogonal partial least squares-discriminant analysis (OPLS-DA) followed by univariate and multivariate logistic regressions to produce the best fit-model for discrimination between groups. RESULTS:The OPLS-DA model was able to distinguish between the AUD group and the other groups with high sensitivity, specificity and accuracy of 64.29%, 98.17% and 91.24% respectively. The logistic regression model identified two biomarkers in plasma (propionic acid and acetic acid) as being significantly associated with alcohol use disorders. The reproducibility of all biomarkers was excellent (0.81-1.0). CONCLUSIONS:The applied plasma metabolomics technique was able to differentiate the metabolites between AUD and the other groups. These metabolites are potential novel biomarkers for diagnosis of alcohol use disorders.
journal_name
J Subst Abuse Treatjournal_title
Journal of substance abuse treatmentauthors
Mostafa H,Amin AM,Teh CH,Murugaiyah VA,Arif NH,Ibrahim Bdoi
10.1016/j.jsat.2017.02.015subject
Has Abstractpub_date
2017-06-01 00:00:00pages
1-5eissn
0740-5472issn
1873-6483pii
S0740-5472(16)30435-4journal_volume
77pub_type
杂志文章abstract::We evaluated a novel intervention designed to improve access to sterile syringes and safe syringe disposal for injection drug users (IDUs) newly enrolled in methadone maintenance, through interviews with two sequential cohorts of 100 recent entrants into a methadone program in the Bronx, NY. A substantial number of pa...
journal_title:Journal of substance abuse treatment
pub_type: 杂志文章
doi:10.1016/j.jsat.2006.03.009
更新日期:2006-07-01 00:00:00
abstract::This article traces the history of two clinical cases. The first case describes a substance abusing patient who enacted the part of a narcotics addict. This enactment was affirmed by both alcohol and narcotic treatment programs, leading to a misdiagnosis. The second case describes a substance using client misdiagnosed...
journal_title:Journal of substance abuse treatment
pub_type: 杂志文章
doi:10.1016/0740-5472(86)90055-3
更新日期:1986-01-01 00:00:00
abstract::White (n = 213), African American (n = 210), and Hispanic (n = 104) Medicaid-eligible, chemically-dependent, pregnant women were interviewed during their stay in stay in publicly-funded detoxification centers in Massachusetts. Comparisons of demographic, psychosocial, and substance abuse variables revealed significant...
journal_title:Journal of substance abuse treatment
pub_type: 杂志文章
doi:10.1016/s0740-5472(96)00153-5
更新日期:1997-09-01 00:00:00
abstract::The I.V. drug abuser who has a history of non-compliance is perhaps the most difficult to reach among those at risk for contracting AIDS. This article details one approach being attempted at HERO, that of a community-based support group run by an indeginous worker where the emphasis is on support, education, and outre...
journal_title:Journal of substance abuse treatment
pub_type: 杂志文章
doi:10.1016/0740-5472(88)90049-9
更新日期:1988-01-01 00:00:00
abstract::In the light of the attachment theory and research outlines the authors develop the concept that addiction is a delayed maladaptive attachment transition in young adults. They look into the relevance of this theoretical framework for therapy in adulthood, especially addiction therapy, connect it with an approach, that...
journal_title:Journal of substance abuse treatment
pub_type: 杂志文章,评审
doi:10.1016/s0740-5472(96)00156-0
更新日期:1996-11-01 00:00:00
abstract::This article presents an analysis of logical inconsistencies in adolescents' reporting of recent substance use to assess the potential effect of inaccurate reporting on measures of treatment outcomes and program performance. We used data on 1,463 clients from 10 adolescent treatment programs to assess the relationship...
journal_title:Journal of substance abuse treatment
pub_type: 杂志文章
doi:10.1016/j.jsat.2007.05.004
更新日期:2008-04-01 00:00:00
abstract::This study explored injection drug users' (IDUs) perceptions of drug abuse treatment and treatment providers in three Russian cities as well as their attitudes toward opiate substitution therapy, which is currently not available in Russia. Data were collected from 121 qualitative interviews with IDUs conducted in 2003...
journal_title:Journal of substance abuse treatment
pub_type: 杂志文章
doi:10.1016/j.jsat.2007.02.002
更新日期:2007-12-01 00:00:00
abstract::The primary goal of this study is to ascertain whether relapse to drug dependence, in terms of continuous abstinence assessment, exhibits a typical pattern that can be characterized by a common quantitative function. If the relapse curve is indeed ubiquitous, then some underlying mechanism must be operating to shape t...
journal_title:Journal of substance abuse treatment
pub_type: 杂志文章,评审
doi:10.1016/j.jsat.2008.04.001
更新日期:2009-01-01 00:00:00
abstract::The purpose of this study was to describe a novel approach to calculating service use costs across multiple domains of service for homeless populations. A randomly-selected sample of homeless persons was interviewed in St. Louis, MO and followed for 2 years. Service- and cost-related data were collected from homeless ...
journal_title:Journal of substance abuse treatment
pub_type: 杂志文章
doi:10.1016/j.jsat.2013.12.002
更新日期:2014-04-01 00:00:00
abstract::This study's purpose is to gain a current perspective on the substance abuse treatment field's workforce. The data are from the Retrospective Study of treatment professionals designed to document how the Treatment Improvement Protocols published by the Center for Substance Abuse Treatment have influenced the implement...
journal_title:Journal of substance abuse treatment
pub_type: 杂志文章
doi:10.1016/s0740-5472(02)00322-7
更新日期:2003-01-01 00:00:00
abstract::As the substance abuse service system shifts from primarily residential to primarily nonresidential settings, it becomes important to understand how substance abuse treatment processes and outcomes may vary across service setting. Research increasingly indicates that, along with specific treatment and service strategi...
journal_title:Journal of substance abuse treatment
pub_type: 杂志文章,多中心研究
doi:10.1016/j.jsat.2011.03.007
更新日期:2011-12-01 00:00:00
abstract:INTRODUCTION:Evidence based psychotherapies (EBPs) remain underutilized. Models for EBP training and implementation that are cost-effective, minimally disruptive, and sufficiently flexible are needed. Internet-based technology is a promising platform, but questions remain about how this technology can address the barri...
journal_title:Journal of substance abuse treatment
pub_type: 杂志文章
doi:10.1016/j.jsat.2015.05.008
更新日期:2015-11-01 00:00:00
abstract::Although substance abuse treatment is associated with improved maternal and neonatal outcomes, pregnant women may be at increased risk of attrition. To explore the hypothesis that shorter waiting time for treatment is associated with increased completion, we analyzed all pregnant treatment admissions and discharges in...
journal_title:Journal of substance abuse treatment
pub_type: 杂志文章
doi:10.1016/j.jsat.2011.01.015
更新日期:2011-07-01 00:00:00
abstract::Most individuals receiving substance abuse treatment also use tobacco, which suggests that smoking cessation is an important clinical target for most clients. Few studies have measured the extent to which addiction treatment counselors address clients' tobacco use. In this study, we examined counselors' implementation...
journal_title:Journal of substance abuse treatment
pub_type: 杂志文章
doi:10.1016/j.jsat.2009.12.002
更新日期:2010-04-01 00:00:00
abstract::Sudden gains (SGs) are defined as abrupt and significant improvements in mental health symptoms that occur between two psychotherapy sessions. Preliminary evidence suggests that SGs may be an important pattern of symptom reduction in the treatment of alcohol use disorder (AUD) (i.e., a steep between-session reduction ...
journal_title:Journal of substance abuse treatment
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jsat.2017.09.014
更新日期:2017-12-01 00:00:00
abstract::Cannabis use disorder (CUD) is the most common illicit substance use disorder in the United States and is related to a range of functional impairment. CUD is associated with comorbid mental health disorders and other substance use disorders, compounding impairment from either type of disorder alone. U.S. military vete...
journal_title:Journal of substance abuse treatment
pub_type: 杂志文章
doi:10.1016/j.jsat.2019.11.003
更新日期:2020-02-01 00:00:00
abstract::The goal of this study was to compare the effects of 1, 3 and 8 mg per day doses of buprenorphine in the maintenance treatment of opium-dependent subjects in Iran over a treatment period of 12 months. Participants were randomized to three equal groups (171 subjects per group) of opium-dependent individuals who met the...
journal_title:Journal of substance abuse treatment
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0740-5472(03)00141-7
更新日期:2004-01-01 00:00:00
abstract::Focus groups were conducted to identify ways persons in recovery from chemical dependence think they have benefited from their struggles with addiction. Categories of positive by-products were identified independently by two sets of readers. Several of the positive by-products discussed by the focus group participants...
journal_title:Journal of substance abuse treatment
pub_type: 杂志文章,多中心研究
doi:10.1016/s0740-5472(00)00151-3
更新日期:2001-01-01 00:00:00
abstract::The purpose of the present study was to investigate whether sociopathic alcoholics respond differentially to different types of treatment. An earlier study found that alcoholics with antisocial personality disorder had somewhat better outcomes if treated in individually focused versus relationship-focused cognitive-be...
journal_title:Journal of substance abuse treatment
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0740-5472(00)00096-9
更新日期:2000-09-01 00:00:00
abstract::The prominence of Twelve-Step programs has led to increased attention on the putative role of spirituality in recovery from addictive disorders. We developed a 6-item Spirituality Self-Rating Scale designed to reflect a global measure of spiritual orientation to life, and we demonstrated here its internal consistency ...
journal_title:Journal of substance abuse treatment
pub_type: 杂志文章
doi:10.1016/j.jsat.2006.06.014
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVES:The current study analyzed the sociodemographic, treatment-related, and other substance use characteristics among pregnant women who reported alcohol use and were admitted to substance use treatment for the first time. METHODS:The Treatment Episode Data Set-Admission (TEDS-A) between 1992 and 2012 was used ...
journal_title:Journal of substance abuse treatment
pub_type: 杂志文章
doi:10.1016/j.jsat.2017.09.010
更新日期:2017-11-01 00:00:00
abstract::The association of physical and sexual abuse with substance abuse has frequently been noted among chemically dependent women. Without diagnosis and treatment of the trauma, female substance abusers are vulnerable to relapse and/or revictimization. This paper describes a model for education and preliminary treatment of...
journal_title:Journal of substance abuse treatment
pub_type: 杂志文章
doi:10.1016/0740-5472(90)90003-9
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND AND AIMS:The Motivational Interviewing Treatment Integrity code (MITI) measures fidelity to, and the quality of, Motivational Interviewing (MI), and can also be used when MI is combined with other treatment methods. The current study presents a fidelity measurement with the MITI 4.2.1, in both Motivational E...
journal_title:Journal of substance abuse treatment
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.jsat.2018.11.004
更新日期:2019-02-01 00:00:00
abstract::Parents who use opioids and are involved in the child welfare system are less likely to retain custody of their children than parents who use other drugs. No previous studies have described medication-assisted treatment (MAT) utilization and child permanency outcomes for this population. The Sobriety Treatment and Rec...
journal_title:Journal of substance abuse treatment
pub_type: 杂志文章
doi:10.1016/j.jsat.2016.09.006
更新日期:2016-12-01 00:00:00
abstract::Overdose education and naloxone distribution (OEND) is an intervention that addresses overdose, but has not been studied among people who take methadone, a drug involved in increasing numbers of overdoses. This study describes the implementation of OEND among people taking methadone in the previous 30 days in various ...
journal_title:Journal of substance abuse treatment
pub_type: 杂志文章
doi:10.1016/j.jsat.2012.07.004
更新日期:2013-02-01 00:00:00
abstract::Many states have responded to the spread of COVID-19 by implementing policies which have led to a dramatic reduction in jail populations. We consider the benefits associated with providing the population of individuals who would, but for these policies, be incarcerated with substance use disorder (SUD) treatment. We d...
journal_title:Journal of substance abuse treatment
pub_type: 杂志文章
doi:10.1016/j.jsat.2020.108147
更新日期:2020-12-01 00:00:00
abstract::One of the unique contributions of this study is a glimpse into the process by which counselors decide to try new innovations in their clinical work. Data were collected from 421 counseling staff from 71 outpatient treatment programs in 4 U.S. regions. Using hierarchical linear modeling, results reveal that the propen...
journal_title:Journal of substance abuse treatment
pub_type: 杂志文章
doi:10.1016/j.jsat.2011.10.014
更新日期:2012-03-01 00:00:00
abstract::Consecutive intakes (N = 419) between ages 13 and 18 years to chemical dependency (CD) programs in a large private health plan were interviewed. The prevalence of six HIV risk behaviors was measured and categorized into zero, one, and multiple risk groups. The relationships between both demographic characteristics and...
journal_title:Journal of substance abuse treatment
pub_type: 杂志文章
doi:10.1016/j.jsat.2005.03.003
更新日期:2005-07-01 00:00:00
abstract::This report describes the current approach to testing for the human immunodeficiency virus (HIV) antibody at Phoenix House, a large therapeutic community (TC) in the northeastern United States, and presents findings on retention of clients who have been tested for HIV antibodies and notified of their HIV serostatus. A...
journal_title:Journal of substance abuse treatment
pub_type: 杂志文章
doi:10.1016/0740-5472(94)90102-3
更新日期:1994-09-01 00:00:00
abstract::The 12-month posttreatment outcome results for a randomized clinical trial that tested the effectiveness of various combinations of 4-month psychosocial treatment interventions are reported for 184 clients who used cocaine. Clients primarily used crack (93%), and the majority were African American (95%). Overall, clie...
journal_title:Journal of substance abuse treatment
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0740-5472(95)02020-9
更新日期:1996-01-01 00:00:00