A Novel Derivative of (-)mycousnine Produced by the Endophytic Fungus Mycosphaerella nawae, Exhibits High and Selective Immunosuppressive Activity on T Cells.

Abstract:

:An endophytic fungus, Mycosphaerella nawae ZJLQ129, was isolated from the leaves of the traditional Chinese medicine Smilax china. From the fermentation broth and mycelium, a dibenzofurane compound (-)mycousnine (1) was isolated. Chemical modification of it to the amide derivative (-)mycousnine enamine (2), which is new to science, was found to have high and selective immunosuppressive activity: similar to cyclosporin A, (-)mycousnine enamine (2) selectively inhibited T cell proliferation, suppressed the expression of the surface activation antigens CD25 and CD69 and the formation and expression of the cytokines interleukin-2 as well as interferon γ in activated T cells, but did not show any effect on the proliferation of B cells and cancer cells (PANC-1 and A549) and the activation of macrophages. Furthermore, the cytotoxicity of (-)mycousnine enamine was lower than that of cyclosporin A, and its therapeutic index (TC50/EC50) was 4,463.5, which is five-fold higher than that of cyclosporin A. We conclude that (-)mycousnine enamine (2), the semi-synthestic product prepared from the native product (-)mycousnine (1) of the endophyte M. nawae is a novel effective immunosuppressant showing low toxicity and high selectivity.

journal_name

Front Microbiol

authors

Wang LW,Wang JL,Chen J,Chen JJ,Shen JW,Feng XX,Kubicek CP,Lin FC,Zhang CL,Chen FY

doi

10.3389/fmicb.2017.01251

subject

Has Abstract

pub_date

2017-07-05 00:00:00

pages

1251

issn

1664-302X

journal_volume

8

pub_type

杂志文章
  • Exopolysaccharides From Streptococcus thermophilus ST538 Modulate the Antiviral Innate Immune Response in Porcine Intestinal Epitheliocytes.

    abstract::It was reported that exopolysaccharides (EPSs) from lactobacilli are able to differentially modulate mucosal antiviral immunity. Although research has described the ability of EPSs derived from Streptococcus thermophilus to modulate the mucosal immune system, their impact on antiviral immunity was less explored. In th...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.00894

    authors: Mizuno H,Tomotsune K,Islam MA,Funabashi R,Albarracin L,Ikeda-Ohtsubo W,Aso H,Takahashi H,Kimura K,Villena J,Sasaki Y,Kitazawa H

    更新日期:2020-05-19 00:00:00

  • Responses of beneficial Bacillus amyloliquefaciens SQR9 to different soilborne fungal pathogens through the alteration of antifungal compounds production.

    abstract::Bacillus amyloliquefaciens SQR9 exhibited predominantly antagonistic activities against a broad range of soilborne pathogens. The fungi-induced SQR9 extracts possess stronger antifungal activities compared with SQR9 monoculture extracts. To investigate how SQR9 fine-tunes lipopeptides (LPs) and a siderophore bacilliba...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2014.00636

    authors: Li B,Li Q,Xu Z,Zhang N,Shen Q,Zhang R

    更新日期:2014-11-21 00:00:00

  • Long-Term Persistent GBV-B Infection and Development of a Chronic and Progressive Hepatitis C-Like Disease in Marmosets.

    abstract::It has been shown that infection of GB virus B (GBV-B), which is closely related to hepatitis C virus, develops acute self-resolving hepatitis in tamarins. In this study we sought to examine longitudinally the dynamics of viral and immunological status following GBV-B infection of marmosets and tamarins. Surprisingly,...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2011.00240

    authors: Iwasaki Y,Mori K,Ishii K,Maki N,Iijima S,Yoshida T,Okabayashi S,Katakai Y,Lee YJ,Saito A,Fukai H,Kimura N,Ageyama N,Yoshizaki S,Suzuki T,Yasutomi Y,Miyamura T,Kannagi M,Akari H

    更新日期:2011-12-07 00:00:00

  • Diversity and Temporal Dynamics of the Epiphytic Bacterial Communities Associated with the Canopy-Forming Seaweed Cystoseira compressa (Esper) Gerloff and Nizamuddin.

    abstract::Canopy-forming seaweed species of the genus Cystoseira form diverse and productive habitats along temperate rocky coasts of the Mediterranean Sea. Despite numerous studies on the rich macrofauna and flora associated with Cystoseira spp., there is little knowledge about the epiphytic bacteria. We analyzed bacterial pop...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2016.00476

    authors: Mancuso FP,D'Hondt S,Willems A,Airoldi L,De Clerck O

    更新日期:2016-04-08 00:00:00

  • Subversion of mucosal barrier polarity by pseudomonas aeruginosa.

    abstract::The lumenal surfaces of human body are lined by a monolayer of epithelia that together with mucus secreting cells and specialized immune cells form the mucosal barrier. This barrier is one of the most fundamental components of the innate immune system, protecting organisms from the vast environmental microbiota. The m...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2011.00114

    authors: Engel J,Eran Y

    更新日期:2011-05-26 00:00:00

  • Patterns and Drivers of Vertical Distribution of the Ciliate Community from the Surface to the Abyssopelagic Zone in the Western Pacific Ocean.

    abstract::The deep sea is one of the largest but least understood ecosystems on earth. Knowledge about the diversity and distribution patterns as well as drivers of microbial eukaryote (including ciliates) along the water column, particularly below the photic zone, is scarce. In this study, we investigated the diversity of pela...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2017.02559

    authors: Zhao F,Filker S,Xu K,Huang P,Zheng S

    更新日期:2017-12-19 00:00:00

  • The outer membrane protease PgtE of Salmonella enterica interferes with the alternative complement pathway by cleaving factors B and H.

    abstract::The virulence factor PgtE is an outer membrane protease (omptin) of the zoonotic pathogen Salmonella enterica that causes diseases ranging from gastroenteritis to severe enteric fever. It is surface exposed in bacteria that have a short-chain, i.e., rough LPS, as observed e.g., in bacteria residing inside macrophages ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2015.00063

    authors: Riva R,Korhonen TK,Meri S

    更新日期:2015-02-06 00:00:00

  • In vitro Evaluation of Photodynamic Effects Against Biofilms of Dermatophytes Involved in Onychomycosis.

    abstract::Dermatophytes are the most common cause of onychomycosis, counting for 90% fungal nail infection. Although dermatophyte pathogens are normally susceptible to antifungal agents, onychomycosis often results in refractory chronic disease, and the formation of biofilms frequently underlines the inadequate responses and re...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.01228

    authors: Chen B,Sun Y,Zhang J,Chen R,Zhong X,Wu X,Zheng L,Zhao J

    更新日期:2019-06-07 00:00:00

  • Intestinal Microbiome-Metabolome Responses to Essential Oils in Piglets.

    abstract::This study investigated the effects of dietary essential oils (EOs) on intestinal microbial composition and metabolic profiles in weaned piglets. The piglets were fed the same basal diet supplemented with EOs (EO) or without EOs (Con) in the current study. The results showed that the body weight gain was significantly...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.01988

    authors: Li Y,Fu X,Ma X,Geng S,Jiang X,Huang Q,Hu C,Han X

    更新日期:2018-08-28 00:00:00

  • Expansion and Divergence of Argonaute Genes in the Oomycete Genus Phytophthora.

    abstract::Modulation of gene expression through RNA interference is well conserved in eukaryotes and is involved in many cellular processes. In the oomycete Phytophthora, research on the small RNA machinery and function has started to reveal potential roles in the pathogen, but much is still unknown. We examined Argonaute (AGO)...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.02841

    authors: Bollmann SR,Press CM,Tyler BM,Grünwald NJ

    更新日期:2018-11-30 00:00:00

  • The mgtCBR mRNA Leader Secures Growth of Salmonella in Both Host and Non-host Environments.

    abstract::Upon intracellular cues, bacterial mRNA leaders often form secondary structures that determine expression of a downstream protein-coding region(s), thereby providing bacteria with a mechanism to control the amounts of necessary proteins in the right locales. Here we describe a polycistronic mRNA leader that secures ba...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.02831

    authors: Park M,Kim H,Nam D,Kweon DH,Shin D

    更新日期:2019-12-06 00:00:00

  • Biophysical features of MagA expression in mammalian cells: implications for MRI contrast.

    abstract::We compared overexpression of the magnetotactic bacterial gene MagA with the modified mammalian ferritin genes HF + LF, in which both heavy and light subunits lack iron response elements. Whereas both expression systems have been proposed for use in non-invasive, magnetic resonance (MR) reporter gene expression, limit...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2014.00029

    authors: Sengupta A,Quiaoit K,Thompson RT,Prato FS,Gelman N,Goldhawk DE

    更新日期:2014-02-05 00:00:00

  • Sample Processing Methods Impacts on Rumen Microbiome.

    abstract::The standardization of collection and processing methods for rumen samples is crucial to reduce the level of errors that may affect the analysis and interpretation of the data. The aim of this study was to compare two processing methods and their impacts on the microbial community composition analysis, from material t...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.00861

    authors: Martinez-Fernandez G,Denman SE,McSweeney CS

    更新日期:2019-04-30 00:00:00

  • Antifungal Streptomyces spp. Associated with the Infructescences of Protea spp. in South Africa.

    abstract::Common saprophytic fungi are seldom present in Protea infructescences, which is strange given the abundance of mainly dead plant tissue in this moist protected environment. We hypothesized that the absence of common saprophytic fungi in Protea infructescences could be due to a special symbiosis where the presence of m...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2016.01657

    authors: Human ZR,Moon K,Bae M,de Beer ZW,Cha S,Wingfield MJ,Slippers B,Oh DC,Venter SN

    更新日期:2016-11-02 00:00:00

  • You Can't B. cereus - A Review of Bacillus cereus Strains That Cause Anthrax-Like Disease.

    abstract::Emerging strains of Bacillus cereus, traditionally considered a self-limiting foodborne pathogen, have been associated with anthrax-like disease in mammals, including humans. The strains have emerged by divergent evolution and, as exchange of genetic material in the Bacillus genus occurs naturally, it is possible that...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章,评审

    doi:10.3389/fmicb.2020.01731

    authors: Baldwin VM

    更新日期:2020-08-19 00:00:00

  • GTP-Dependent FlhF Homodimer Supports Secretion of a Hemolysin in Bacillus cereus.

    abstract::The multidomain (B-NG) protein FlhF, a flagellar biogenesis regulator in several bacteria, is the third paralog of the signal recognition particle (SRP)-GTPases Ffh and FtsY, which are known to drive protein-delivery to the plasma membrane. Previously, we showed that FlhF is required for Bacillus cereus pathogenicity ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.00879

    authors: Mazzantini D,Fonnesu R,Celandroni F,Calvigioni M,Vecchione A,Mrusek D,Bange G,Ghelardi E

    更新日期:2020-05-06 00:00:00

  • Accessory Proteins of the Nitrogenase Assembly, NifW, NifX/NafY, and NifZ, Are Essential for Diazotrophic Growth in the Nonheterocystous Cyanobacterium Leptolyngbya boryana.

    abstract::Since nitrogenase is extremely vulnerable to oxygen, aerobic or micro-aerobic nitrogen-fixing organisms need to create anaerobic microenvironments in the cells for diazotrophic growth, which would be one of the major barriers to express active nitrogenase in plants in efforts to create nitrogen-fixing plants. Numerous...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.00495

    authors: Nonaka A,Yamamoto H,Kamiya N,Kotani H,Yamakawa H,Tsujimoto R,Fujita Y

    更新日期:2019-03-15 00:00:00

  • Oxalic Acid Production in Clarireedia jacksonii Is Dictated by pH, Host Tissue, and Xylan.

    abstract::Dollar spot is caused by the fungus Clarireedia jacksonii and is the most common disease of golf course turfgrass in temperate climates. Oxalic acid (OA) is an important pathogenicity factor in other fungal plant pathogens, such as the dicot pathogen Sclerotinia sclerotiorum, but its role in C. jacksonii pathogenicity...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.01732

    authors: Townsend RV,Rioux RA,Kabbage M,Stephens C,Kerns JP,Koch P

    更新日期:2020-08-04 00:00:00

  • Deciphering the Urinary Microbiota Repertoire by Culturomics Reveals Mostly Anaerobic Bacteria From the Gut.

    abstract::Human urine was considered sterile for a long time. However, 416 species have been previously cultured, including only 40 anaerobic species. Here, we used culturomics, particularly those targeting anaerobes, to better understand the urinary microbiota. By testing 435 urine samples, we isolated 450 different bacterial ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.513305

    authors: Dubourg G,Morand A,Mekhalif F,Godefroy R,Corthier A,Yacouba A,Diakite A,Cornu F,Cresci M,Brahimi S,Caputo A,Lechevallier E,Tsimaratos M,Moal V,Lagier JC,Raoult D

    更新日期:2020-10-16 00:00:00

  • Genomic and Functional Characterization of Enterococcus mundtii QAUEM2808, Isolated From Artisanal Fermented Milk Product Dahi.

    abstract::Microbial strains with a unique combination of technological and bioactive properties are preferred for industrial applications. The present study was conducted to evaluate the potential use of Enterococcus mundtii QAUEM2808 (NCBI Accession Number: LSMC00000000) in milk fermentation. This strain was isolated from Dahi...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.00434

    authors: Nawaz F,Khan MN,Javed A,Ahmed I,Ali N,Ali MI,Bakhtiar SM,Imran M

    更新日期:2019-03-26 00:00:00

  • Unveiling the Biogeography and Potential Functions of the Intestinal Digesta- and Mucosa-Associated Microbiome of Donkeys.

    abstract::The intestinal microbial composition and metabolic functions under normal physiological conditions in the donkey are crucial for health and production performance. However, compared with other animal species, limited information is currently available regarding the intestinal microbiota of donkeys. In the present stud...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.596882

    authors: Zhang R,Zhang J,Dang W,Irwin DM,Wang Z,Zhang S

    更新日期:2020-12-04 00:00:00

  • Biocatalytic desulfurization of thiophenic compounds and crude oil by newly isolated bacteria.

    abstract::Microorganisms possess enormous highly specific metabolic activities, which enable them to utilize and transform nearly every known chemical class present in crude oil. In this context, one of the most studied biocatalytic processes is the biodesulfurization (BDS) of thiophenic sulfur-containing compounds such as benz...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2015.00112

    authors: Mohamed Mel-S,Al-Yacoub ZH,Vedakumar JV

    更新日期:2015-02-13 00:00:00

  • Modulation of Plant and Fungal Gene Expression Upon Cd Exposure and Symbiosis in Ericoid Mycorrhizal Vaccinium myrtillus.

    abstract::The success of Ericaceae in stressful habitats enriched in heavy metals has been ascribed to the distinctive abilities of their mycorrhizal fungal partners to withstand heavy metal stress and to enhance metal tolerance in the host plant. Whereas heavy metal tolerance has been extensively investigated in some ericoid m...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.00341

    authors: Casarrubia S,Martino E,Daghino S,Kohler A,Morin E,Khouja HR,Murat C,Barry KW,Lindquist EA,Martin FM,Perotto S

    更新日期:2020-03-09 00:00:00

  • Transcriptome Analysis Reveals the Flexibility of Cordycepin Network in Cordyceps militaris Activated by L-Alanine Addition.

    abstract::Cordycepin, isolated from the traditional medicinal fungus Cordyceps militaris, has gained much attention due to its various clinical functions. Previous reports of L-alanine addition could significantly improve cordycepin production, but the molecular mechanism remains unknown. In this study, transcriptome analysis o...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.00577

    authors: Chen BX,Wei T,Xue LN,Zheng QW,Ye ZW,Zou Y,Yang Y,Yun F,Guo LQ,Lin JF

    更新日期:2020-04-24 00:00:00

  • Antibiotic Resistance: Moving From Individual Health Norms to Social Norms in One Health and Global Health.

    abstract::Antibiotic resistance is a problem for human health, and consequently, its study had been traditionally focused toward its impact for the success of treating human infections in individual patients (individual health). Nevertheless, antibiotic-resistant bacteria and antibiotic resistance genes are not confined only to...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章,评审

    doi:10.3389/fmicb.2020.01914

    authors: Hernando-Amado S,Coque TM,Baquero F,Martínez JL

    更新日期:2020-08-28 00:00:00

  • Nitric oxide and nitrous oxide turnover in natural and engineered microbial communities: biological pathways, chemical reactions, and novel technologies.

    abstract::Nitrous oxide (N(2)O) is an environmentally important atmospheric trace gas because it is an effective greenhouse gas and it leads to ozone depletion through photo-chemical nitric oxide (NO) production in the stratosphere. Mitigating its steady increase in atmospheric concentration requires an understanding of the mec...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2012.00372

    authors: Schreiber F,Wunderlin P,Udert KM,Wells GF

    更新日期:2012-10-23 00:00:00

  • Insights Into the Evolution of Staphylococcus aureus Daptomycin Resistance From an in vitro Bioreactor Model.

    abstract::The extensive use of daptomycin for treating complex methicillin-resistant Staphylococcus aureus infections has led to the emergence of daptomycin-resistant strains. Although genomic studies have identified mutations associated with daptomycin resistance, they have not necessarily provided insight into the evolution a...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.00345

    authors: Lasek-Nesselquist E,Lu J,Schneider R,Ma Z,Russo V,Mishra S,Pai MP,Pata JD,McDonough KA,Malik M

    更新日期:2019-02-28 00:00:00

  • Highly Sensitive Colorimetric Biosensor for Staphylococcal Enterotoxin B by a Label-Free Aptamer and Gold Nanoparticles.

    abstract::A simple, sensitive and selective colorimetric biosensor for the detection of Staphylococcal enterotoxin B (SEB) was developed using SEB-binding aptamer (SEB2) as recognition element and unmodified gold nanoparticles (AuNPs) as colorimetric probes. The assay is based on color change from red to purple due to conformat...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.00179

    authors: Mondal B,Ramlal S,Lavu PS,N B,Kingston J

    更新日期:2018-02-13 00:00:00

  • The Rho Termination Factor of Clostridium botulinum Contains a Prion-Like Domain with a Highly Amyloidogenic Core.

    abstract::Prion-like proteins can switch between a soluble intrinsically disordered conformation and a highly ordered amyloid assembly. This conformational promiscuity is encoded in specific sequence regions, known as prion domains (PrDs). Prions are best known as the causative factors of neurological diseases in mammals. Howev...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2015.01516

    authors: Pallarès I,Iglesias V,Ventura S

    更新日期:2016-01-07 00:00:00

  • The 287,403 bp Mitochondrial Genome of Ectomycorrhizal Fungus Tuber calosporum Reveals Intron Expansion, tRNA Loss, and Gene Rearrangement.

    abstract::In the present study, the mitogenome of Tuber calosporum was assembled and analyzed. The mitogenome of T. calosporum comprises 15 conserved protein-coding genes, two rRNA genes, and 14 tRNAs, with a total size of 287,403 bp. Fifty-eight introns with 170 intronic open reading frames were detected in the T. calosporum m...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.591453

    authors: Li X,Li L,Bao Z,Tu W,He X,Zhang B,Ye L,Wang X,Li Q

    更新日期:2020-12-09 00:00:00