Abstract：
OBJECTIVES:To investigate a link between the appearance of photoacoustic imaging (PAI) and microvasculature in prostate cancer and to assess the feasibility of PAI for angiogenesis imaging in prostate cancer. METHODS:We have developed a PAI system equipped with a transrectal ultrasound (TRUS)-type probe. Three patients who underwent PAI just before prostate biopsy and subsequently underwent radical prostatectomy were included. The PAI appearance was retrospectively reviewed, and in each patient, 4 representative areas were selected: 1 with high PAI signal intensity, 1 with low PAI signal intensity, 1 peripheral to the index tumor, and 1 inside the index tumor. The correlation of PAI intensity with 3 microvascular parameters-microvascular density, total vascular area (TVA), and total vascular length (TVL)-assessed by CD34-immunostaining in resected specimens was analyzed. RESULTS:In all 3 patients the PAI intensity, TVA, and TVL in areas with high-intensity PAI signals were significantly higher than those in areas with low-intensity PAI signals, suggesting that PAI appearance describes the distribution of microvasculature in prostatic tissue correctly. All index tumors showed a ring-like PAI appearance consisting of a peripheral area of high signal intensity completely or partially surrounding an area with low signal intensity. The PAI intensity, TVA, and TVL in the periphery of the index tumors were significantly higher than those inside of the index tumors. CONCLUSION:The intensity of PAI signals might reflect the microvascularity in normal prostatic tissues and index tumors. PAI could be a novel modality for imaging prostate cancer angiogenesis.
journal_name
Urologyjournal_title
Urologyauthors
Horiguchi A,Shinchi M,Nakamura A,Wada T,Ito K,Asano T,Shinmoto H,Tsuda H,Ishihara Mdoi
10.1016/j.urology.2017.07.008subject
Has Abstractpub_date
2017-10-01 00:00:00pages
212-219eissn
0090-4295issn
1527-9995pii
S0090-4295(17)30733-1journal_volume
108pub_type
杂志文章相关文献
UROLOGY文献大全abstract：OBJECTIVES:Recent studies have shown that growth factors may play a role in the etiology of benign prostatic hyperplasia (BPH) and prostatic carcinoma. Several growth factors have been reported to be expressed by prostatic tissues, but these growth factors have never been examined in human fetal prostate and compared w...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(96)00376-7
更新日期：1996-12-01 00:00:00
abstract：:The experience gained from the implantation of 763 Flexirod Prosthesis is described. Special features of this design include a tapered distal tip which provides for better glans stability, a soft hinge which allows for improved penile concealment, and a trimmable tail which, together with preoperative measurement of t...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(84)90247-4
更新日期：1984-05-01 00:00:00
abstract：:Adult Wilms tumor is still considered a rarity. Approximately 170 adult Wilms tumors have been reported. The final diagnosis is usually established with surgery. There is no specific radiologic diagnosis of adult Wilms tumor. We report on a case of Wilms tumor in a twenty-two-year-old black man. The tumor was removed ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(87)90182-8
更新日期：1987-08-01 00:00:00
abstract：:Schwannoma of the penis is a rare tumor. We report a case of penile schwannoma in a young man who was accurately diagnosed preoperatively with the help of gray-scale and color flow Doppler ultrasonography, and confirmed by magnetic resonance imaging. The tumor was successfully resected to completion, with preservation...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2007.05.003
更新日期：2007-08-01 00:00:00
abstract：OBJECTIVE:To characterize human bladder smooth muscle cell reactions to disturbed oxygen tension. Clinical studies have shown a close correlation between bladder ischemia and lower urinary tract symptoms in elderly patients. MATERIALS AND METHODS:Confluent cultured human bladder smooth muscle cells were incubated unde...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2011.06.034
更新日期：2011-10-01 00:00:00
abstract：OBJECTIVES:To estimate the relationship between serum prostate-specific antigen (PSA) and prostatic epithelial volume, a new simple method for measuring epithelial volume was developed and its efficacy evaluated in patients with benign prostatic hyperplasia. METHODS:Between March 1998 and June 2001, 122 patients witho...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(02)02159-3
更新日期：2003-02-01 00:00:00
abstract：OBJECTIVE:To characterize the changes in urine composition associated with increasing severity of diabetes, we analyzed urine composition relative to glycated hemoglobin (HbA1c) and treatment strategy in a largely minority population. METHODS:Patients treated for kidney stones between 2001 and 2013 at a single tertiar...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2015.10.013
更新日期：2016-01-01 00:00:00
abstract：:Continent urinary diversion has become an attractive alternative to traditional conduits after cystectomy in select patients, including those awaiting renal transplantation. We report a case of a surgically anephric dialysis patient who underwent radical cystoprostatectomy with orthotopic ileal neobladder for recurren...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(02)01895-2
更新日期：2002-11-01 00:00:00
abstract：OBJECTIVE:To compare the postprocedural oral pain scale and other patient reported oral morbidities for nonclosure vs closure of buccal mucosal graft (BMG) harvest sites through systematic review and meta-analysis of comparative studies. METHODS:A systematic literature search was performed in September 2018. Nonrandom...
journal_title：Urology
pub_type： 杂志文章,meta分析
doi：10.1016/j.urology.2018.12.008
更新日期：2019-03-01 00:00:00
abstract：:Renal cell carcinoma demonstrates expansive growth and invasion of adjacent structures. Direct liver extension, although uncommon, is a dismal prognostic sign. We propose radical nephrectomy en bloc with right lateral sector (segments 6 and 7) of the liver. The operative procedure was performed in 2 male patients, 61 ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(01)00939-6
更新日期：2001-05-01 00:00:00
abstract：:In many countries of the world, prostate cancer is the second most common form of cancer in men, and in the United States it is now in first rank. It is an important public health problem, with > 0.25 million new cases diagnosed worldwide in the year 1985. Whereas earlier large increases in the incidence of prostate c...
journal_title：Urology
pub_type： 杂志文章,评审
doi：10.1016/s0090-4295(99)80250-7
更新日期：1995-09-01 00:00:00
abstract：OBJECTIVE:To examine histologic findings and clinical outcomes of patients who underwent neck dissection for residual neck masses. METHODS:From 1987 to 2008, 968 postchemotherapy retroperitoneal lymph node dissections (RPLND) were performed at our institution. We identified 41 of these patients who underwent a postche...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2010.10.002
更新日期：2011-03-01 00:00:00
abstract：OBJECTIVES:Despite the introduction of the new World Health Organization 2004 grading classification, the grading of urothelial carcinoma remains difficult and subjective. The aim of this study was to evaluate the role of computer-assisted image morphometric analysis as a tool to improve the objectivity of histologic g...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2007.09.003
更新日期：2007-11-01 00:00:00
abstract：OBJECTIVE:To report an alternative form of management of a persistent lymphocele that was unresponsive to percutaneous drainage and ethanol sclerotherapy. METHODS:Herein is described the technique of dilating the previously established percutaneous drainage tract to facilitate insertion of a flexible ureteroscope. Thr...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(94)90091-4
更新日期：1994-03-01 00:00:00
abstract：:Erdheim-Chester disease is a rare systemic non-Langerhans cell histiocytosis. We report the first case of surgical treatment of severe compression of renal parenchyma by retroperitoneal masses in a 61-year-old male patient with progressing renal failure. After 3 years of follow-up, we have concluded that the open surg...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2004.10.051
更新日期：2005-04-01 00:00:00
abstract：:In a retrospective review of patients who underwent salvage cystectomy, patients with muscle-invasive cancers who had initially presented with tumors that were pathologically TA or T1 appeared to have a better prognosis than those who had muscle-invasive (T2 or T3) cancers on initial clinical presentation. Prognosis i...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(83)90489-2
更新日期：1983-08-01 00:00:00
abstract：OBJECTIVE:To evaluate variation in neoadjuvant chemotherapy (NAC) use among patients with ≥ clinical T2 (cT2) bladder cancer and determine changes in staging at radical cystectomy (RC) associated with therapy. METHODS:Using the National Cancer Database (NCDB), we identified all patients diagnosed with organ-confined, ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2013.07.072
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVES:To perform systemic 22-core transperineal ultrasound-guided template prostate biopsies in patients with previous negative transrectal ultrasound-guided prostate biopsy findings and evaluate the cancer core distribution. METHODS:Between April 2001 and December 2003, 128 men underwent systemic ultrasound-guid...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2005.01.051
更新日期：2005-07-01 00:00:00
abstract：:Late relapses of nonseminomatous germ cell tumors of the testicle are unusual. In such cases, chemotherapy is reported to have only modest success and surgery may be the preferred treatment modality. We report a patient who experienced relapse 11 years after the initial diagnosis of advanced testicular cancer and who ...
journal_title：Urology
pub_type： 杂志文章,评审
doi：10.1016/S0090-4295(96)00495-5
更新日期：1997-03-01 00:00:00
abstract：:An adult male with posterior urethral valves who had obstructive urinary symptoms and painless gross hematuria is presented. The diagnosis, development, and treatment of posterior urethral valves is discussed. The importance of also treating the hypertrophied bladder neck is stressed. ...
journal_title：Urology
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：OBJECTIVE:To assess the outcome of cystectomy and cystourethrectomy in patients with intractable interstitial cystitis or bladder pain syndrome, and to identify whether urethrectomy is necessary. METHODS AND MATERIALS:During 2007-2014, 18 women were eligible and elected for surgical treatment after conservative treatm...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2016.07.003
更新日期：2016-11-01 00:00:00
abstract：OBJECTIVES:To determine the mechanism for the 46,XX/46,XY karyotype observed in a patient with an ovotesticular disorder of sexual development (ie, true hermaphroditism). METHODS:Cytogenetic, molecular cytogenetic, and molecular DNA analyses were performed on the blood, skin, and left and right gonadal tissue from 2 s...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2008.08.428
更新日期：2009-02-01 00:00:00
abstract：OBJECTIVE:To compare pathological characteristics, treatment patterns, and survival in patients with ductal adenocarcinoma (DC) compared to those with acinar adenocarcinoma (AC). MATERIALS AND METHODS:Using the National Cancer Database, we identified patients diagnosed with clinically localized (cN0, cM0) pure DC (n =...
journal_title：Urology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.urology.2015.07.009
更新日期：2015-10-01 00:00:00
abstract：OBJECTIVES:To investigate an alternative technique using an onlay patch of porcine small intestine submucosa (SIS) allograft to bridge a ureteral defect. For ureteral strictures that fail endourologic management, few options are available for minimally invasive repair or reconstruction. Although laparoscopic interposit...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(02)01890-3
更新日期：2002-11-01 00:00:00
abstract：OBJECTIVE:To retrospectively evaluate the clinical outcomes of 20 patients diagnosed with a nonpalpable or small testicular mass (2 cm) at 2 academic urological department. Testis-sparing surgery (TSS) is currently performed routinely for the management of nonpalpable testicular masses. High reliability of frozen secti...
journal_title：Urology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.urology.2011.12.039
更新日期：2012-04-01 00:00:00
abstract：OBJECTIVE:To treat mild-to-moderate apical compartment prolapse while preserving the uterus, our extraperitoneal uterosacral ligament hysteropexy repair technique was developed. Hysterectomy for prolapse accounted for 13% of all benign hysterectomies, which is the third most common reason.1 Although concomitant hystere...
journal_title：Urology
pub_type：
doi：10.1016/j.urology.2020.02.026
更新日期：2020-06-01 00:00:00
abstract：OBJECTIVES:Visual laser ablation of the prostate (VLAP) is a relatively new option for relief of urinary outlet obstruction secondary to benign prostatic hyperplasia. There is currently no consensus regarding the optimum use of antibiotic prophylaxis in VLAP. This study was designed to evaluate two dosage regimens of a...
journal_title：Urology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0090-4295(94)80189-4
更新日期：1994-12-01 00:00:00
abstract：:Two cases of megalourethra are presented, the ninth and tenth cases to be documented in the literature. Both patients exhibited mesodermal abnormalities which justify categorization among the minor forms of prune belly syndrome. One patient, the youngest to have undergone surgical correction, presented with azotemia, ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(78)90366-7
更新日期：1978-07-01 00:00:00
abstract：OBJECTIVE:To investigate the expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) protein in the interstitial cells of Cajal (ICCs) of the human bladder and to determine the relative expression of the HCN subtypes. METHODS:A total of 30 bladder specimens were obtained, and each bladder sample was di...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2012.04.005
更新日期：2012-07-01 00:00:00
abstract：OBJECTIVE:To determine if use of the hematuria risk index can reduce testing and cost, while maintaining equivalent lesion detection in patients with asymptomatic microscopic hematuria. MATERIALS AND METHODS:Retrospective cohort study of 1049 patients at single institution. Hematuria risk index score was calculated ba...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2020.03.045
更新日期：2020-07-01 00:00:00
