5-HT3 receptor antagonists injected into the area postrema inhibit cisplatin-induced emesis in the ferret.

abstract：BACKGROUND AND PURPOSE:Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors, and three subtypes (α, β and γ) have been identified. PPAR activation has been reported to decrease renal injury and markers of glomerular dysfunction in models of renal ischemia/reperfusion (I/R). How...

journal_title：British journal of pharmacology

authors： Miglio G,Rosa AC,Rattazzi L,Grange C,Collino M,Camussi G,Fantozzi R

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The presence of the histamine H₄ receptor (H₄R) was previously reported in benign and malignant lesions and cell lines derived from the human mammary gland. The aim of this work was to evaluate the effects of H₄R ligands on the survival, tumour growth rate and metastatic capacity of breast cancer...

journal_title：British journal of pharmacology

authors： Martinel Lamas DJ,Croci M,Carabajal E,Crescenti EJ,Sambuco L,Massari NA,Bergoc RM,Rivera ES,Medina VA

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The aim of this study was to identify the actions of H(2)S on ion transport across rat distal colon. EXPERIMENTAL APPROACH:Changes in short-circuit current (Isc) induced by the H(2)S-donor, NaHS, were measured in Ussing chambers. Cytosolic Ca(2+) concentration was evaluated using fura-2. KEY RE...

journal_title：British journal of pharmacology

authors： Hennig B,Diener M

更新日期：2009-11-01 00:00:00

abstract：:5-Lipoxygenase (5-LO) is a crucial enzyme in the synthesis of the bioactive leukotrienes (LTs) from arachidonic acid (AA), and inhibitors of 5-LO are thought to prevent the untowarded pathophysiological effects of LTs. In this study, we present the molecular pharmacological profile of the novel nonredox-type 5-LO inhi...

journal_title：British journal of pharmacology

authors： Fischer L,Steinhilber D,Werz O

更新日期：2004-07-01 00:00:00

abstract：:1. The effects of noradrenaline, endothelin-1, acetylcholine and sodium nitroprusside were studied in isolated pulmonary arteries obtained from 14 patients undergoing lobectomy for lung carcinoma. Seven patients had shown increased response to a bronchodilator test prior to operation. In the remaining patients (contro...

journal_title：British journal of pharmacology

authors： Cases E,Vila JM,Medina P,Aldasoro M,Segarra G,Lluch S

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Sildenafil is a selective inhibitor of cGMP-specific phosphodiesterase. Sildenafil, acting via NO-dependent mechanisms, prevents indomethacin-induced gastropathy. Activation of ATP-sensitive potassium channels (K(ATP)) is involved in gastric defence. Our objective was to evaluate the role of the ...

journal_title：British journal of pharmacology

authors： Medeiros JV,Gadelha GG,Lima SJ,Garcia JA,Soares PM,Santos AA,Brito GA,Ribeiro RA,Souza MH

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Certain 5-lipoxygenase (5-LO) inhibitors exhibit anti-carcinogenic activities against 5-LO overexpressing tumour types and cultured tumour cells. It has been proposed therefore that 5-LO products significantly contribute to tumour cell proliferation. To date, the relationship between the inhibito...

journal_title：British journal of pharmacology

authors： Fischer AS,Metzner J,Steinbrink SD,Ulrich S,Angioni C,Geisslinger G,Steinhilber D,Maier TJ

更新日期：2010-10-01 00:00:00

abstract：:1. The mechanisms underlying the vasodilator response to urocortin are incompletely understood. The present study was designed to examine the role of endothelial nitric oxide and Ba(2+)-sensitive K(+) channels in the endothelium-dependent component of urocortin-induced relaxation in the rat left anterior descending co...

journal_title：British journal of pharmacology

authors： Huang Y,Chan FL,Lau CW,Tsang SY,He GW,Chen ZY,Yao X

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Diabetes mellitus is associated with a specific cardiomyopathy. We compared the cardioprotective effects of an endothelin-A receptor blocker (ET(A)-RB) with those of an angiotensin-converting enzyme inhibitor (ACE-I) in rats with streptozotocin (STZ)-induced diabetes. EXPERIMENTAL APPROACH:Diabe...

journal_title：British journal of pharmacology

authors： Wölkart G,Pang X,Stessel H,Kirchengast M,Brunner F

更新日期：2007-08-01 00:00:00

abstract：:1. The present study was designed to investigate tolerance to several pharmacological effects of apomorphine. 2. Changes in blood pressure, heart rate, plasma noradrenaline levels, rectal temperature, respiratory rate and retching plus vomiting were compared after administration of apomorphine (200 micrograms kg-1, i....

journal_title：British journal of pharmacology

authors： Montastruc JL,Llau ME,Senard JM,Tran MA,Rascol O,Montastruc P

更新日期：1996-03-01 00:00:00

abstract：:1. The effect of trimebutine on the voltage-dependent inward Ca2+ current was investigated by the whole-cell voltage-clamp technique in single smooth muscle cells from rabbit ileum. 2. Trimebutine (3-100 microM) reduced the Ca2+ current in a concentration-dependent manner. The inhibitory effect on the Ca2+ current was...

journal_title：British journal of pharmacology

authors： Nagasaki M,Komori S,Ohashi H

更新日期：1993-09-01 00:00:00

abstract：:1. Human epicardial coronary artery rings, freshly obtained from cardiac transplant patients, were examined for their responses to endothelium-derived relaxing factor (EDRF)-releasing agents. 2. Functional antagonism profoundly influenced relaxation responses in this tissue. Increasing force with concentrations of U46...

journal_title：British journal of pharmacology

authors： Stork AP,Cocks TM

更新日期：1994-12-01 00:00:00

abstract：:1. An investigation into the effects of cholecystokinin octapeptide (CCK-8S) and its pentapeptide analogue, pentagastrin, on neurones located in ventromedial nuclei of rat hypothalamic slices maintained in vitro has been undertaken. 2. CCK-8S (0.01-1.0 microM) applied in the perfusion medium produced a concentration-d...

journal_title：British journal of pharmacology

authors： Boden P,Hill RG

更新日期：1988-05-01 00:00:00

abstract：:1. The relationship between the capacity of the chick biventer preparation, both intact tissue and homogenate, to inactivate acetylcholine and the ability of eserine to increase the sensitivity of the tissue to acetylcholine have been investigated.2. At concentrations of eserine of 2.69 x 10(-9)M and 2.69 x 10(-8)M th...

journal_title：British journal of pharmacology

authors： Baldwin DW,Lesser E

更新日期：1971-07-01 00:00:00

abstract：:1. The mechanisms underlying the postjunctional blockade induced by phenthonium [N-(4-phenyl) phenacyl 1-hyoscyamine] were investigated in mammalian and amphibian muscles. This muscarinic antagonist was previously shown to enhance specifically the spontaneous acetylcholine (ACh) release at concentrations that blocked ...

journal_title：British journal of pharmacology

authors： Souccar C,Lima-Landman MT,Ballejo G,Lapa AJ

更新日期：1998-07-01 00:00:00

abstract：:1. The nature and cellular mechanisms that are responsible for endothelium-dependent relaxations resistant to indomethacin and NG-nitro-L-arginine methyl ester (L-NAME) were investigated in phenylephrine (PE) precontracted isolated carotid arteries from the rabbit. 2. In the presence of the cyclo-oxygenase inhibitor, ...

journal_title：British journal of pharmacology

authors： Dong H,Waldron GJ,Galipeau D,Cole WC,Triggle CR

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Postsystolic wall thickening (PSWT) is part of thickening that occurs after end-systole and represents wasted effort as it does not contribute to ejection. The effects of antianginal drugs on PSWT remain to be established. We compared the effects on PSWT of two agents that reduce heart rate, the ...

journal_title：British journal of pharmacology

authors： Lucats L,Ghaleh B,Colin P,Monnet X,Bizé A,Berdeaux A

更新日期：2007-02-01 00:00:00

abstract：:1. The effect of prolonged anti-hypertensive drug treatment on the blood pressure of conscious spontaneously hypertensive rats (SH-rats), and of age-matched normotensive Sprague-Dawley rats was determined during the development of hypertension in SH-rats and in the early stages of established hypertension. A compariso...

journal_title：British journal of pharmacology

authors： Hamilton TC

更新日期：1975-08-01 00:00:00

abstract：:The effect of a substance P antagonist, [D-Pro2, D-Trp7,9]-substance P (SPA), on gastric emptying and gastrointestinal transit in the rat was studied in order to elucidate a possible physiological role of endogenous substance P and other tachykinins in gastrointestinal motility. SPA was given by intraperitoneal inject...

journal_title：British journal of pharmacology

authors： Holzer P,Holzer-Petsche U,Leander S

更新日期：1986-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Gut microbiota plays an important role in type 2 diabetes mellitus (T2DM) progression. From our previous work N-(4-Hydroxyphenethyl)-3-mercapto-2-methylpropanamide (HMPA) is a potential T2DM drug. We evaluated the effect of HMPA on gut microbiota and studied the molecular mechanism underlying HMP...

journal_title：British journal of pharmacology

authors： Liu H,Qin Y,Li K,Li M,Yang J,Tao H,Tang Y,Yang L,Chen S,Liu Y,Yang C,Gao W,Sun T

更新日期：2020-12-07 00:00:00

abstract：BACKGROUND AND PURPOSE:Our team previously demonstrated that diabetes induces a deterioration in vascular dynamics, in parallel with the enhanced formation of advanced glycation end products. The aim of this study was to determine whether prevention of the arterial stiffening by pyridoxamine in diabetes is associated w...

journal_title：British journal of pharmacology

authors： Chang KC,Liang JT,Tsai PS,Wu MS,Hsu KL

更新日期：2009-08-01 00:00:00

abstract：:The role of putative neurotransmitters of the central nervous system in the central gastric antisecretory effect of prostaglandin E2 (PGE2) was investigated in pylorus-ligated rats. Pretreatment of the rats with an intracerebroventricular (i.c.v.) injection of 6-hydroxydopamine (6-OHDA) prevented the antisecretory eff...

journal_title：British journal of pharmacology

authors： Puurunen J

更新日期：1985-05-01 00:00:00

abstract：:1. Insulin antibodies were induced in young guinea-pigs of both sexes weighing 300-400 g and housed in a room maintained at 28 degrees C+/-2 degrees C, by subcutaneous injection of 2 ml of freshly prepared insulin antigen emulsion between the shoulders once every month.2. To estimate the titre of serum antibody the se...

journal_title：British journal of pharmacology

authors： Gulati OD,Patel DG

更新日期：1971-05-01 00:00:00

abstract：:Ever increasing use of engineered carbon nanoparticles in nanopharmacology for selective imaging, sensor or drug delivery systems has increased the potential for blood platelet-nanoparticle interactions. We studied the effects of engineered and combustion-derived carbon nanoparticles on human platelet aggregation in v...

journal_title：British journal of pharmacology

authors： Radomski A,Jurasz P,Alonso-Escolano D,Drews M,Morandi M,Malinski T,Radomski MW

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We determined the effects of treatment with LR-90, an inhibitor of advanced glycation end products, on the mechanical properties of the arterial system in streptozotocin (STZ)-induced diabetic Sprague Dawley rats, using aortic impedance analysis, and further investigated the effects of LR-90 on t...

journal_title：British journal of pharmacology

authors： Satheesan S,Figarola JL,Dabbs T,Rahbar S,Ermel R

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Chronic stress impairs GABAA (GABA type A) receptor-mediated inhibition in the hypothalamic paraventricular nucleus (PVN). It is not clear whether GABAB receptor function is also altered. We hypothesize that chronic stress alters GABAB receptor function in PVN corticotrophin-releasing hormone (CR...

journal_title：British journal of pharmacology

authors： Gao Y,Zhou JJ,Zhu Y,Wang L,Kosten TA,Zhang X,Li DP

更新日期：2017-09-01 00:00:00

abstract：:1. Neural crest material from neurula stage Xenopus embryos was tissue cultured as small aggregates of cells or a single cell suspension. Isolated pigment cells differentiated after 2 days in culture. 2. Melatonin (10(-15) to 10(-13) M) induced pigment granule condensation; it was 10,000 times more effective than any ...

journal_title：British journal of pharmacology

authors： Messenger EA,Warner AE

更新日期：1977-12-01 00:00:00

abstract：:1 Dose-related increases in airways resistance (Raw) and decreases in dynamic lung compliance (Cdyn) were recorded in guinea-pigs and rats following intravenous injection of propranolol and of the cardioselective beta-adrenoceptor blocking drugs, atenolol and practolol. 2 The bronchoconstriction reached a peak in 2 to...

journal_title：British journal of pharmacology

authors： Maclagan J,Ney UM

更新日期：1979-07-01 00:00:00

abstract：:1. The present study was undertaken to determine the mechanism of action of endothelin-1 (ET-1)-induced contraction of the guinea-pig isolated trachea. 2. ET-1 (1 nM-0.3 microM) produces a concentration-dependent contraction of guinea-pig trachea with an EC50 of approximately 25 nM. The combination of the peptidoleuko...

journal_title：British journal of pharmacology

authors： Hay DW,Hubbard WC,Undem BJ

更新日期：1993-11-01 00:00:00

abstract：:1. The GABA-B receptor agonists baclofen and 3-aminopropylphosphinic acid (3-APPi) have antitussive activity in the cat and guinea pig. The purpose of this study was to investigate the sites of action of these GABA-B receptor agonists to inhibit the cough reflex. 2. Single intracerebroventricular (i.c.v.) cannulas wer...

journal_title：British journal of pharmacology

authors： Bolser DC,DeGennaro FC,O'Reilly S,Chapman RW,Kreutner W,Egan RW,Hey JA

更新日期：1994-12-01 00:00:00