Phytochemical analysis and anti-inflammatory evaluation of compounds from an aqueous extract of Croton cajucara Benth.

Abstract:

:Croton cajucara Benth. is a medicinal plant popularly used in the Brazilian Amazonia, where it is known as sacaca, being consumed as tea, decoction or infusion of the leaves and stem bark. From a decoction of the leaves, a comprehensive phytochemical analysis was developed by liquid chromatography-mass spectrometry. Many compounds were identified for the first time in C. cajucara, such as O-glycosides of kaempferol and quercetin, flavonoid-C-glycosides, tannins and cinnamic acid derivatives. These compounds were fractionated by polarity and assayed for their anti-inflammatory activity, using a model of mice edema, induced by an intraplantar injection of carrageenan. All fractions exhibited anti-inflammatory properties.

journal_name

J Pharm Biomed Anal

authors

Nascimento AM,Maria-Ferreira D,Dal Lin FT,Kimura A,de Santana-Filho AP,Werner MFP,Iacomini M,Sassaki GL,Cipriani TR,de Souza LM

doi

10.1016/j.jpba.2017.07.032

subject

Has Abstract

pub_date

2017-10-25 00:00:00

pages

821-830

eissn

0731-7085

issn

1873-264X

pii

S0731-7085(17)30515-0

journal_volume

145

pub_type

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