Recent Advances in Ergosterol Biosynthesis and Regulation Mechanisms in Saccharomyces cerevisiae.


:Ergosterol, an important component of the fungal cell membrane, is not only essential for fungal growth and development but also very important for adaptation to stress in fungi. Ergosterol is also a direct precursor for steroid drugs. The biosynthesis of ergosterol can be divided into three modules: mevalonate, farnesyl pyrophosphate (farnesyl-PP) and ergosterol biosynthesis. The regulation of ergosterol content is mainly achieved by feedback regulation of ergosterol synthase activity through transcription, translation and posttranslational modification. The synthesis of HMG-CoA, catalyzed by HMGR, is a major metabolic check point in ergosterol biosynthesis. Excessive sterols can be subsequently stored in lipid droplets or secreted into the extracellular milieu by esterification or acetylation to avoid toxic effects. As sterols are insoluble, the intracellular transport of ergosterol in cells requires transporters. In recent years, great progress has been made in understanding ergosterol biosynthesis and its regulation in Saccharomyces cerevisiae. However, few reviews have focused on these studies, especially the regulation of biosynthesis and intracellular transport. Therefore, this review summarizes recent research progress on the physiological functions, biosynthesis, regulation of biosynthesis and intracellular transportation of ergosterol in S. cerevisiae.


Indian J Microbiol


Hu Z,He B,Ma L,Sun Y,Niu Y,Zeng B




Has Abstract


2017-09-01 00:00:00














  • Detection of Wolbachia Phage (WO) in Indian Lac Insect [Kerria lacca (Kerr.)] and Its Implications.

    abstract::Wolbachia, a maternally inherited bacterium induces reproductive alterations in its hosts such as feminization of males, male killing and parthenogenesis. It is the most diverse endosymbiont infecting more than 70% of the insects ranging from pests to pollinators. Kerria lacca-a hemipteran is a sedentary, oriental ins...

    journal_title:Indian journal of microbiology

    pub_type: 杂志文章


    authors: Kaushik S,Sharma KK,Ramani R,Lakhanpaul S

    更新日期:2019-06-01 00:00:00

  • Efficacy of cryptdin-2 as an adjunct to antibiotics from various generations against salmonella.

    abstract::Emerging drug resistance in Salmonella coupled with the recent poor success rate of antibiotic discovery programs of the pharmaceutical industry is a cause for significant concern. It has forced the scientific community to look for alternative new classes of antimicrobial compounds. In this context, combinations of an...

    journal_title:Indian journal of microbiology

    pub_type: 杂志文章


    authors: Singh AP,Prabha V,Rishi P

    更新日期:2014-09-01 00:00:00

  • Endophytic Penicillium citrinum Thom. from Scoparia dulcis Linn.

    abstract::Scoparia dulcis of Scrophulariaceae is an annual herb distributed through out the tropics. Penicillium citrinum was obtained from apparently healthy roots, stem, leaves and fruits of this plant. Callus and multiple shoots produced during micropropagation from various explants were also symptomless but showed occurrenc...

    journal_title:Indian journal of microbiology

    pub_type: 杂志文章


    authors: Mathew AJ,Jayachandran K,Mathew J

    更新日期:2010-10-01 00:00:00

  • Molecular Modeling of Cloned Bacillus subtilis Keratinase and Its Insinuation in Psoriasis Treatment Using Docking Studies.

    abstract::Present study demonstrated the expression of cloned Bacillus subtilis RSE163 keratinase gene and in silico binding affinities of deduced protein with psoriasis topical drugs for systemic absorption and permeation through skin. The ker gene expressed in E. coli showed significantly higher keratinase activity 450 ± 10.4...

    journal_title:Indian journal of microbiology

    pub_type: 杂志文章


    authors: Gupta S,Tewatia P,Misri J,Singh R

    更新日期:2017-12-01 00:00:00

  • Bio-softening of mature coconut husk for facile coir recovery.

    abstract::Bio-softening of the mature coconut husk using Basidiomyceteous fungi was attempted to recover the soft and whiter fibers. The process was faster and more efficient in degrading lignin and toxic phenolics. Phanerochaete chrysosporium, Pleurotus eryngii and Ceriporiopsis subvermispora were found to degrade lignin effic...

    journal_title:Indian journal of microbiology

    pub_type: 杂志文章


    authors: Suganya DS,Pradeep S,Jayapriya J,Subramanian S

    更新日期:2007-06-01 00:00:00

  • Evaluation of Probiotic Characteristics of Lactic Acid Bacteria Isolated from Two Commercial Preparations Available in Indian Market.

    abstract::The enormous health benefits associated with probiotics has resulted in an increased consumption of probiotic supplements. Several factors like regular sub-culturing, storage, unfavourable conditions etc. might compromise the efficacy and/or safety of lactic acid bacteria which are the major components of many probiot...

    journal_title:Indian journal of microbiology

    pub_type: 杂志文章


    authors: Singhal N,Singh NS,Mohanty S,Singh P,Virdi JS

    更新日期:2019-03-01 00:00:00

  • Copper(II) Complexes with N,O-Donor Ligands and Ofloxacin Drug as Antibacterial, DNA Interacting, Cytotoxic and SOD Mimic Agent.

    abstract:ABSTRACT:The N,O-donor bidentate ligands (L (1) -L (7) ) derived from the reaction between chalcones and pyridinium salt of 2-acetyl furan were synthesized and characterized by IR and NMR spectroscopic techniques. Their complexes [1-7] of Cu(II) were synthesized and characterized by elemental analysis, magnetic measure...

    journal_title:Indian journal of microbiology

    pub_type: 杂志文章


    authors: Karia PS,Vekariya PA,Patidar AP,Patel MN

    更新日期:2015-09-01 00:00:00

  • Fungal isolates from natural pectic substrates for polygalacturonase and multienzyme production.

    abstract::Pectin rich wastes and waste dump yard soils were screened and eighty pectinolytic fungal isolates were obtained by enrichment culturing and ruthenium red plate assay. Eight isolates with higher zones of pectin hydrolysis were selected and tested for polygalacturonase production. One isolate identified as Aspergillus ...

    journal_title:Indian journal of microbiology

    pub_type: 杂志文章


    authors: Anuradha K,Padma PN,Venkateshwar S,Reddy G

    更新日期:2010-09-01 00:00:00

  • Biodiversity of phosphate solubilizing bacteria in rhizosphere of chickpea, mustard and wheat grown in different regions of Haryana.

    abstract::The native population of phosphate solubilizing bacteria (PSB) was studied in the rhizosphere of chickpea, mustard and wheat grown in different regions of Haryana. A total of 193 PSB were isolated from 245 rhizospheric samples collected from south-west and north-east zones. The PSB count showed large variations (3-67 ...

    journal_title:Indian journal of microbiology

    pub_type: 杂志文章


    authors: Kundu BS,Nehra K,Yadav R,Tomar M

    更新日期:2009-06-01 00:00:00

  • Simultaneous Biodegradation of Polyaromatic Hydrocarbons by a Stenotrophomonas sp: Characterization of nid Genes and Effect of Surfactants on Degradation.

    abstract::A polyaromatic hydrocarbon degrading bacterium was isolated from a petroleum contaminated site and designated as Stenotrophomonas sp. strain IITR87. It was found to utilize pyrene, phenanthrene and benzo(a)pyrene as sole carbon source, but not anthracene, chrysene and fluoranthene. Gas chromatography and mass spectros...

    journal_title:Indian journal of microbiology

    pub_type: 杂志文章


    authors: Kumari S,Regar RK,Bajaj A,Ch R,Satyanarayana GNV,Mudiam MKR,Manickam N

    更新日期:2017-03-01 00:00:00

  • Nutritional and toxicological assessment of white-rot fermented animal feed.

    abstract::The fungal fermented wheat straws as animal feeds have been evaluated for its toxicological and nutritional status in male rats (Holtzman strain). Digestibility of dry matter and other nutrients as well as fiber fractions were found significantly higher (P < 0.05) in straw fermented with either Ganoderma sp. rckk02 (T...

    journal_title:Indian journal of microbiology

    pub_type: 杂志文章


    authors: Sharma KK,Shrivastava B,Nandal P,Sehgal N,Sastry VR,Kalra A,Kuhad RC

    更新日期:2012-06-01 00:00:00

  • Isolation an Aldehyde Dehydrogenase Gene from Metagenomics Based on Semi-nest Touch-Down PCR.

    abstract::Culture-independent approaches to analyze metagenome are practical choices for rapid exploring useful genes. The mg-MSDH gene, acquired from the hot spring metagenomic, was retrieved full lengths of functional gene using semi-nest touch-down PCR. Two pairs of degenerate primers were used to separate seven conserve par...

    journal_title:Indian journal of microbiology

    pub_type: 杂志文章


    authors: Chen R,Li C,Pei X,Wang Q,Yin X,Xie T

    更新日期:2014-03-01 00:00:00

  • Improvement in symbiotic efficiency of chickpea (Cicer arietinum) by coinoculation of Bacillus strains with Mesorhizobium sp. Cicer.

    abstract::Rhizobacteria belonging to Bacillus sp. were isolated from the rhizosphere of chickpea (Cicer arietinum). Ten Bacillus strains were studied for their antifungal activity, effect on seedling emergence and plant growth promotion. Two Bacillus strains CBS127 and CBS155 inhibited the growth of all the four pathogenic fung...

    journal_title:Indian journal of microbiology

    pub_type: 杂志文章


    authors: Sivaramaiah N,Malik DK,Sindhu SS

    更新日期:2007-03-01 00:00:00

  • Bacterial and Archaeal Communities within an Ultraoligotrophic, High-altitude Lake in the Pre-Himalayas of the Qinghai-Tibet Plateau.

    abstract::Puma Yumco Lake (PYL) is an ultraoligotrophic freshwater lake that sits an altitude of 5030 m within the Qinghai-Tibet Plateau of China. The bacterial and archaeal diversity of the lake remains poorly understood, despite their potential to inform on biogeochemical cycling and environment-microbial associations in thes...

    journal_title:Indian journal of microbiology

    pub_type: 杂志文章


    authors: Wang R,Han R,Long Q,Gao X,Xing J,Shen G,Zhu D

    更新日期:2020-09-01 00:00:00

  • Commentary: Reconciling Hygiene and Cleanliness: A New Perspective from Human Microbiome.

    abstract::Human beings have co-evolved with the microorganisms in our environment for millions of years, and have developed into a symbiosis in a mutually beneficial/defensive way. Human beings have significant multifaceted relationships with the diverse microbial community. Apart from the important protective role of microbial...

    journal_title:Indian journal of microbiology

    pub_type: 杂志文章


    authors: Yu B,Yu B,Yu L

    更新日期:2020-06-01 00:00:00

  • Production of N-acyl Homoserine Lactones and Virulence Factors of Waterborne Aeromonas hydrophila.

    abstract::Aeromonads are inhabitants of aquatic ecosystems and are described as being involved in intestinal disturbances and other infections. The purpose of this study was to investigate the production of N-acyl-homoserine lactone (AHL) signal molecules and some virulence factors, including hemolysins, proteases, extracellula...

    journal_title:Indian journal of microbiology

    pub_type: 杂志文章


    authors: Chu W,Liu Y,Jiang Y,Zhu W,Zhuang X

    更新日期:2013-09-01 00:00:00

  • Isolation and Characterization of Antibacterial Compound from a Mangrove-Endophytic Fungus, Penicillium chrysogenum MTCC 5108.

    abstract::Microorganisms, especially endophytic fungi that reside in the tissue of living mangrove plants, seem to play a major role in meeting the general demand for new biologically active substances. During the course of screening for biologically active secondary metabolites from marine microorganisms, an antibiotic compoun...

    journal_title:Indian journal of microbiology

    pub_type: 杂志文章


    authors: Devi P,Rodrigues C,Naik CG,D'Souza L

    更新日期:2012-12-01 00:00:00

  • Sequence analysis of a salt tolerant metagenomic clone.

    abstract::Metagenome represent an unlimited resource for discovery of novel genes. Here we report, sequence analysis of a salt tolerant metagenomic clone (6B4) from a pond water metagenomic library. Clone 6B4 had an insert of 2254 bp with G+C composition of 64.06%. DNA sequence from 6B4 showed homology to DNA sequences from pro...

    journal_title:Indian journal of microbiology

    pub_type: 杂志文章


    authors: Kapardar RK,Ranjan R,Puri M,Sharma R

    更新日期:2010-06-01 00:00:00

  • High Prevalence and Significant Association of ESBL and QNR Genes in Pathogenic Klebsiella pneumoniae Isolates of Patients from Kolkata, India.

    abstract::Pathogenic Klebsiella pneumoniae, resistant to beta-lactam and quinolone drugs, is widely recognized as important bacteria causing array of diseases. The resistance property is obtained by acquisition of plasmid encoded blaTEM, blaSHV, blaCTX-M, QNRA, QNRB and QNRS genes. The aim of this study was to document the prev...

    journal_title:Indian journal of microbiology

    pub_type: 杂志文章


    authors: Tripathi A,Dutta SK,Majumdar M,Dhara L,Banerjee D,Roy K

    更新日期:2012-12-01 00:00:00

  • Recent Advancements in the Development of Modern Probiotics for Restoring Human Gut Microbiome Dysbiosis.

    abstract::A healthy gut is predominantly occupied by bacteria which play a vital role in nutrition and health. Any change in normal gut homeostasis imposes gut dysbiosis. So far, efforts have been made to mitigate the gastrointestinal symptoms using modern day probiotics. The majority of the probiotics strains used currently be...

    journal_title:Indian journal of microbiology

    pub_type: 杂志文章,评审


    authors: Kumar R,Sood U,Gupta V,Singh M,Scaria J,Lal R

    更新日期:2020-03-01 00:00:00

  • Induced systemic resistance (ISR) in plants: mechanism of action.

    abstract::Plants possess a range of active defense apparatuses that can be actively expressed in response to biotic stresses (pathogens and parasites) of various scales (ranging from microscopic viruses to phytophagous insect). The timing of this defense response is critical and reflects on the difference between coping and suc...

    journal_title:Indian journal of microbiology

    pub_type: 杂志文章


    authors: Choudhary DK,Prakash A,Johri BN

    更新日期:2007-12-01 00:00:00

  • Co-inoculation of Urea and DAP Tolerant Sinorhizobium meliloti and Pseudomonas aeruginosa as Integrated Approach for Growth Enhancement of Brassica juncea.

    abstract::Two plant growth promoting rhizobacteria--Sinorhizobium meliloti RMP1 and Pseudomonas aeruginosa GRC(2) were studied for integrated nutrient management to obtain improved yield of Brassica juncea. Low concentrations of urea and diammonium phosphate (DAP) stimulated the growth of both S. meliloti RMP1 and P. aeruginosa...

    journal_title:Indian journal of microbiology

    pub_type: 杂志文章


    authors: Maheshwari DK,Kumar S,Kumar B,Pandey P

    更新日期:2010-10-01 00:00:00

  • Interaction of Azospirillum brasilense and Glomus intrarradix in Sugar Cane Roots.

    abstract::Fifteen-day-old variety NA 56-79 sugar cane seedlings were inoculated with Azospirillum brasilense and Glomus intrarradix. This article aims at examining changes in sugar cane root seedlings inoculated with Glomus intrarradix and Azospirillum brasilense, the increase in microbial biomass and the acetylene reduction pr...

    journal_title:Indian journal of microbiology

    pub_type: 杂志文章


    authors: Bellone CH,de Bellone Silvia C

    更新日期:2012-03-01 00:00:00

  • Detection and Capturing of (14)C Radioactively-Labeled Small Subunit rRNA from Mixed Microbial Communities of a Microbial Mat Using Magnetic Beads.

    abstract::Carbon cycling in the hypersaline microbial mats from Chiprana Lake, Spain is primarily dependent on phototrophic microorganisms with the ability to fix CO2 into organics that can be further utilized by aerobic as well as anaerobic heterotrophic bacteria. Here, mat pieces were incubated in seawater amended with (14)C ...

    journal_title:Indian journal of microbiology

    pub_type: 杂志文章


    authors: Abed RM

    更新日期:2012-03-01 00:00:00

  • Microbial extracellular polymeric substances: central elements in heavy metal bioremediation.

    abstract::Extracellular polymeric substances (EPS) of microbial origin are a complex mixture of biopolymers comprising polysaccharides, proteins, nucleic acids, uronic acids, humic substances, lipids, etc. Bacterial secretions, shedding of cell surface materials, cell lysates and adsorption of organic constituents from the envi...

    journal_title:Indian journal of microbiology

    pub_type: 杂志文章


    authors: Pal A,Paul AK

    更新日期:2008-03-01 00:00:00

  • Bioleaching of low-grade uranium ore using Acidithiobacillus ferrooxidans.

    abstract::Bioleaching of uranium was carried out with Turamdih ore sample procured from Uranium Corporation of India Limited, Jaduguda. The bacterial strain that was used in the leaching experiments was isolated from the Jaduguda mine water sample. Efficiency of bioleaching was studied by varying parameters like pulp density an...

    journal_title:Indian journal of microbiology

    pub_type: 杂志文章


    authors: Pal S,Pradhan D,Das T,Sukla LB,Chaudhury GR

    更新日期:2010-03-01 00:00:00

  • Improved Sprouting and Growth of Mung Plants in Chromate Contaminated Soils Treated with Marine Strains of Staphylococcus Species.

    abstract::Marine bacteria possess a wide variety of bioremediation potential which is beneficial environmentally and economically. In this study, bacterial isolates from marine waters were screened for tolerance and growth in high concentrations of chromate (Cr6+). Two isolates, capable of tolerating Cr6+ concentrations 300 µg ...

    journal_title:Indian journal of microbiology

    pub_type: 杂志文章


    authors: Pereira EJ,Fonseca S,Meena RM,Ramaiah N

    更新日期:2017-12-01 00:00:00

  • Evaluation of Gamma-Radiation Inactivation of a Bioterrorism Agent, Bacillus anthracis Spores, on Different Materials.

    abstract::Decontamination of suspected packages, such as sealed envelopes, liquids and tools that are likely contaminated with biological agents is of great importance. In this study, we aimed to determine the gamma radiation dose required for the decontamination of paper, fabric and liquid materials without causing any damage ...

    journal_title:Indian journal of microbiology

    pub_type: 杂志文章


    authors: Ortatatli M,Canitez K,Sezigen S,Eyison RK,Kenar L

    更新日期:2018-03-01 00:00:00

  • Microbiological and engineering aspects of biohydrogen production.

    abstract::Dramatically rising oil prices and increasing awareness of the dire environmental consequences of fossil fuel use, including startling effects of climate change, are refocusing attention worldwide on the search for alternative fuels. Hydrogen is poised to become an important future energy carrier. Renewable hydrogen p...

    journal_title:Indian journal of microbiology

    pub_type: 杂志文章


    authors: Hallenbeck PC,Ghosh D,Skonieczny MT,Yargeau V

    更新日期:2009-03-01 00:00:00

  • Resuscitation promoting factors: a family of microbial proteins in survival and resuscitation of dormant mycobacteria.

    abstract::Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), is an extraordinarily successful pathogen of humankind. It has been estimated that up to one-third of the world's population is infected with M. tuberculosis, and this population is an important reservoir for disease reactivation. Resuscitation prom...

    journal_title:Indian journal of microbiology

    pub_type: 杂志文章


    authors: Gupta RK,Srivastava R

    更新日期:2012-06-01 00:00:00