Vagus Nerve Stimulation for Electrographic Status Epilepticus in Slow-Wave Sleep.

Abstract:

BACKGROUND:Electrographic status epilepticus in slow sleep or continuous spike and waves during slow-wave sleep is an epileptic encephalopathy characterized by seizures, neurocognitive regression, and significant activation of epileptiform discharges during nonrapid eye movement sleep. There is no consensus on the diagnostic criteria and evidence-based optimal treatment algorithm for children with electrographic status epilepticus in slow sleep. PATIENT DESCRIPTION:We describe a 12-year-old girl with drug-resistant electrographic status epilepticus in slow wave sleep that was successfully treated with vagus nerve stimulation. Her clinical presentation, presurgical evaluation, decision-making, and course after vagus nerve stimulator implantation are described in detail. FINDINGS:After vagus nerve stimulator implantation, the girl remained seizure free for more than a year, resolved the electrographic status epilepticus in slow sleep pattern on electroencephalography, and exhibited significant cognitive improvement. CONCLUSION:Vagus nerve stimulation may be considered for electrographic status epilepticus in slow sleep.

journal_name

Pediatr Neurol

journal_title

Pediatric neurology

authors

Carosella CM,Greiner HM,Byars AW,Arthur TM,Leach JL,Turner M,Holland KD,Mangano FT,Arya R

doi

10.1016/j.pediatrneurol.2016.02.016

subject

Has Abstract

pub_date

2016-07-01 00:00:00

pages

66-70

eissn

0887-8994

issn

1873-5150

pii

S0887-8994(15)30267-8

journal_volume

60

pub_type

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