Magnesium Modulates Doxorubicin Activity through Drug Lysosomal Sequestration and Trafficking.

abstract：:The efficacy of 3-tert-butyl-4-hydroxyanisole (BHA) as a chemopreventive agent against chemically induced cancer or toxicity may involve the direct modulation of cytochrome P-450 dependent monooxygenase function. This hypothesis was investigated by using purified rabbit cytochrome P-450IA2 and P-450IIB4 in a reconstit...

journal_title：Chemical research in toxicology

authors： Rodrigues AD,Fernandez D,Nosarzewski MA,Pierce WM Jr,Prough RA

更新日期：1991-05-01 00:00:00

abstract：:In May 1981, a massive food-borne intoxication occurred in Spain. The so-called toxic oil syndrome (TOS) was associated with the consumption of aniline-denatured and refined rapeseed oil that was illegally sold as edible olive oil. Fatty acid anilides and fatty acid derivatives of 3-(phenylamino)propane-1,2-diol were ...

journal_title：Chemical research in toxicology

authors： Ladona MG,Bujons J,Messeguer A,Ampurdanés C,Morató A,Corbella J

更新日期：1999-12-01 00:00:00

abstract：:Furanoid 8-epidiosbulbin E acetate (EEA) is one of the most abundant diterpenoid lactones in herbal medicine Dioscorea bulbifera L. (DB). Our early work proved that EEA could be metabolized to EEA-derived cis-enedial (EDE), a reactive intermediate, which is required for the hepatotoxicity observed in experimental anim...

journal_title：Chemical research in toxicology

authors： Zhou S,Zhang N,Hu Z,Lin D,Li W,Peng Y,Zheng J

更新日期：2020-07-20 00:00:00

abstract：:Anxiolytic kava products have been associated with rare but severe hepatotoxicity in humans. This adverse potential has never been captured in animal models, and the responsible compound(s) remains to be determined. The lack of such knowledge greatly hinders the preparation of a safer kava product and limits its benef...

journal_title：Chemical research in toxicology

authors： Narayanapillai SC,Leitzman P,O'Sullivan MG,Xing C

更新日期：2014-10-20 00:00:00

abstract：:The location of carcinogen-modified nucleobases (DNA adducts) within DNA sequences is a critical factor affecting their promutagenic properties and persistence in DNA. We now report the use of controlled exonuclease digestion followed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MAL...

journal_title：Chemical research in toxicology

authors： Tretyakova N,Matter B,Ogdie A,Wishnok JS,Tannenbaum SR

更新日期：2001-08-01 00:00:00

abstract：:MXenes have attracted extensive attention due to their unique physicochemical properties. Especially, the flexibility and good conductivity endow MXenes with a great application prospect in the neural interfaces. However, the cytotoxicity of MXenes to nervous system remains unclear. In this study, we evaluated the cyt...

journal_title：Chemical research in toxicology

authors： Wu W,Ge H,Zhang L,Lei X,Yang Y,Fu Y,Feng H

更新日期：2020-12-21 00:00:00

abstract：:The risk of potential human exposure to mixed nanomaterials in consumer, occupational, and medicinal settings is increasing as nanomaterials enter both the workplace and the marketplace. In this study, we investigated the toxicity of mixed engineered carbon black (ECB) and maghemite iron oxide (Fe(2)O(3)) nanoparticle...

journal_title：Chemical research in toxicology

authors： Berg JM,Ho S,Hwang W,Zebda R,Cummins K,Soriaga MP,Taylor R,Guo B,Sayes CM

更新日期：2010-12-20 00:00:00

abstract：:Covalent binding of drug reactive metabolites to neutrophils or their precursors is thought to play a role in the development of drug-induced agranulocytosis. In this study, we used immunochemical techniques to compare the covalent binding of clozapine, vesnarinone, and procainamide (three drugs associated with agranu...

journal_title：Chemical research in toxicology

authors： Gardner I,Popović M,Zahid N,Uetrecht JP

更新日期：2005-09-01 00:00:00

abstract：:The mechanism of DNA adduct formation by acroleins substituted with good leaving groups in the beta-position was investigated using [3-2H]-3-(p-nitrophenoxy)acrolein (1). Reaction of 1 with guanosine at acidic pH produced 9-beta-D-ribofuranosylpyrimido[1,2-alpha]purin-10(3H)-one containing equal amounts of deuterium a...

journal_title：Chemical research in toxicology

authors： Reddy GR,Marnett LJ

更新日期：1996-01-01 00:00:00

abstract：:Oxidative stress is associated with the pathophysiology of many degenerative human diseases, including Alzheimer's disease, atherosclerosis, Parkinson's disease, and cancers. We discovered in our previous study that thioproline (SPro), a proline analogue, is generated in oxidant-exposed cells. With the prior observati...

journal_title：Chemical research in toxicology

authors： Ham YH,Jason Chan KK,Chan W

更新日期：2020-07-20 00:00:00

abstract：:The crystal structure of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) has been determined by single-crystal X-ray crystallography. Crystals grown by evaporation of an aqueous solution form in the monoclinic space group P2(1)/n with two molecules of PhIP per asymmetric unit, along with six w...

journal_title：Chemical research in toxicology

authors： Parkin S,Marsch GA,Hope H,Whitney E,Winter NW,Colvin ME,Felton JS,Turteltaub KW

更新日期：1996-04-01 00:00:00

abstract：:The complex composition of welding fumes, multiplicity of molecular targets, diverse cellular effects, and lifestyles associated with laborers vastly complicate the assessment of welding fume exposure. The urinary metabolomic profiles of 35 male welders and 16 male office workers at a Taiwanese shipyard were character...

journal_title：Chemical research in toxicology

authors： Wang KC,Kuo CH,Tian TF,Tsai MH,Chiung YM,Hsiech CM,Tsai SJ,Wang SY,Tsai DM,Huang CC,Tseng YJ

更新日期：2012-03-19 00:00:00

abstract：:Lapatinib (LAP), an oral tyrosine kinase inhibitor for the treatment of metastatic breast cancer, has been associated with idiosyncractic hepatotoxicity. Recent investigations have implicated the importance of P450 3A4/5 enzymes in the formation of an electrophilic quinone imine (LAPQI) metabolite generated through fu...

journal_title：Chemical research in toxicology

authors： Eno MR,El-Gendy Bel-D,Cameron MD

更新日期：2016-05-16 00:00:00

abstract：:Acrolein is a bifunctional electrophile, present as an ubiquitous environmental pollutant and an endogenous cellular product of lipid peroxidation. Reaction of acrolein with deoxyguanosine produces two regioisomeric DNA adducts, specifically gamma-hydroxypropanodeoxyguanosine (gamma-HOPdG) and alpha-hydroxypropanodeox...

journal_title：Chemical research in toxicology

authors： Sanchez AM,Minko IG,Kurtz AJ,Kanuri M,Moriya M,Lloyd RS

更新日期：2003-08-01 00:00:00

abstract：:Recent reports by Galeazzi and co-workers demonstrated the susceptibility of Abeta(1-42) to undergo dityrosine formation via peroxidase-catalyzed tyrosine cross-linking. We have formed dityrosine cross-links in Abeta(1-40) using these enzymatic conditions as well as a copper-H(2)O(2) method. The efficiency of dityrosi...

journal_title：Chemical research in toxicology

authors： Yoburn JC,Tian W,Brower JO,Nowick JS,Glabe CG,Van Vranken DL

更新日期：2003-04-01 00:00:00

abstract：:The DNA alkylating mechanism of PNU-159682 (PNU), a highly potent metabolite of the anthracycline nemorubicin, was investigated by gel-electrophoretic, HPLC-UV, and micro-HPLC/mass spectrometry (MS) measurements. PNU quickly reacted with double-stranded oligonucleotides, but not with single-stranded sequences, to form...

journal_title：Chemical research in toxicology

authors： Scalabrin M,Quintieri L,Palumbo M,Riccardi Sirtori F,Gatto B

更新日期：2017-02-20 00:00:00

abstract：:Proton pump inhibitors (PPIs) are extensively used for the treatment of gastric acid-related disorders. PPIs appear to be well tolerated and almost have no short-term side effects. However, the clinical adverse reactions of long-term PPI usage are increasingly reported in recent years. So far, there is no study that e...

journal_title：Chemical research in toxicology

authors： Wu D,Qiu T,Zhang Q,Kang H,Yuan S,Zhu L,Zhu R

更新日期：2015-03-16 00:00:00

abstract：:The relation between organophosphorus-induced delayed neuropathy (OPIDN) and brain neuropathy target esterase (NTE) inhibition is further examined in hens by structure-activity studies leading to the most potent in vitro NTE inhibitors known, which are then examined for their neuropathic effects in vivo in hens. The p...

journal_title：Chemical research in toxicology

authors： Wu SY,Casida JE

更新日期：1995-12-01 00:00:00

abstract：:Our laboratory previously reported the identification and quantification of depurinating DNA adducts of dibenzo[a,l]pyrene (DB[a,l]P) in vitro, which comprise about 84% of all the DNA adducts that are formed [Li, K.-M., et al. (1995) Biochemistry 34, 8043-8049]. To determine a complete adduct profile and identify both...

journal_title：Chemical research in toxicology

authors： Devanesan P,Ariese F,Jankowiak R,Small GJ,Rogan EG,Cavalieri EL

更新日期：1999-09-01 00:00:00

abstract：:Organochlorine (OC) compounds are some of the main toxicants present in the food web and target several cellular systems including the nonspecific immune system. The objective of this study was to test the hypothesis that OC compounds that activate neutrophils share common structural features. Using activation of phos...

journal_title：Chemical research in toxicology

authors： Olivero J,Bezdecny SA,Ganey PE

更新日期：2002-02-01 00:00:00

abstract：:Oxidative stress is believed to play a role in the pathogenesis of several diseases, including diabetes and inborn errors of metabolism. The types of oxidative damage observed in these pathologies have been attributed to the excessive production of reactive intermediates relating to the accumulation of toxic metabolit...

journal_title：Chemical research in toxicology

authors： Royer LO,Knudsen FS,de Oliveira MA,Tavares MF,Bechara EJ

更新日期：2004-12-01 00:00:00

abstract：:Deferoxamine is an inhibitor of iron-dependent free radical reactions. Despite the antioxidant roles, prolonged clinical use of the chelator is far from benign, and paradoxically, deferoxamine has been shown to promote lipid peroxidation. The possible toxicity of the drug's metabolites, such as deferoxamine nitroxide ...

journal_title：Chemical research in toxicology

authors： Kiyose M,Lee CI,Okabe E

更新日期：1999-02-01 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), 1-nitropyrene (1-NP), and benzo[a]pyrene (BaP) are toxic environmental pollutants. TCDD was shown to suppress p53 expression in response to genotoxic stress and hypoxic conditions. However, the mechanism of TCDD's actions is not clearly understood. Our data showed that pretr...

journal_title：Chemical research in toxicology

authors： Su JG,Huang MC,Chen FY

更新日期：2011-12-19 00:00:00

abstract：:Toxicity data for 82 aliphatic chemicals with an alpha,beta-unsaturated substructure were compiled. Toxicity was assessed in the 2-day Tetrahymena pyriformis population growth impairment assay. Toxic potency [log(IGC50(-1))] for most of these chemicals was in excess of baseline narcosis as quantified by the 1-octanol/...

journal_title：Chemical research in toxicology

authors： Schultz TW,Netzeva TI,Roberts DW,Cronin MT

更新日期：2005-02-01 00:00:00

abstract：:Marine toxins such as brevetoxins and ciguatoxins are produced by dinoflagellates and can accumulate in seafood. These toxins affect humans through seafood consumption. Intoxication is mainly characterized by gastrointestinal and neurological disorders and, in most severe cases, by cardiovascular problems. To prevent ...

journal_title：Chemical research in toxicology

authors： Louzao MC,Vieytes MR,Yasumoto T,Botana LM

更新日期：2004-04-01 00:00:00

abstract：:The metabolic fates of the nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its two-electron oxidation product, the 1-methyl-4-phenyl-2,3-dihydropyridinium species (MPDP+), have been examined in mouse brain and liver tissue fractions. Incubations of MPTP (50 microM and 1 mM) with mouse brain...

journal_title：Chemical research in toxicology

authors： Wu E,Shinka T,Caldera-Munoz P,Yoshizumi H,Trevor A,Castagnoli N Jr

更新日期：1988-05-01 00:00:00

abstract：:The Adverse Outcome Pathway (AOP) paradigm details the existing knowledge that links the initial interaction between a chemical and a biological system, termed the molecular initiating event (MIE), through a series of intermediate events, to an adverse effect. An important example of a well-defined MIE is the formatio...

journal_title：Chemical research in toxicology

authors： Ebbrell DJ,Madden JC,Cronin MT,Schultz TW,Enoch SJ

更新日期：2016-06-20 00:00:00

abstract：:We propose here a combined gas chromatography/mass spectrometry (GC/MS) and liquid chromatography/mass spectrometry (LC/MS) metabolic profiling strategy to elucidate the toxicity in rats induced by orally administered multiglycosides of Tripterygium wilfordii Hook. f. (GTW) in multiple organs including the kidney, liv...

journal_title：Chemical research in toxicology

authors： Chen M,Ni Y,Duan H,Qiu Y,Guo C,Jiao Y,Shi H,Su M,Jia W

更新日期：2008-02-01 00:00:00

abstract：:Alzheimer's disease, the most common cause of dementia, is at epidemic proportions (15 to 44% depending on age, of those age 65 to 84) in the U.S. and other developed countries but remains relatively rare in undeveloped countries. Surprisingly, solid historical data reveal the epidemic is a creature of the last centur...

journal_title：Chemical research in toxicology

authors： Brewer GJ

更新日期：2017-03-20 00:00:00

abstract：:3,N4-Etheno-2'-deoxycytidine, 3-(hydroxyethyl)-2'-deoxyuridine, and 3,N4-ethano-2'-deoxy-cytidine are found in DNA of cells treated with either vinyl chloride or 1,3-bis(2-chloroethyl)-nitrosourea. These exocyclic and related DNA adducts were incorporated into oligodeoxynucleotides, which were then used as templates f...

journal_title：Chemical research in toxicology

authors： Zhang W,Johnson F,Grollman AP,Shibutani S

更新日期：1995-01-01 00:00:00