Abstract:
:Interaction studies of bisphenol analogues; biphenol-A (BPA), bisphenol-B (BPB), and bisphenol-F (BPF) with bovine serum albumin (BSA) were performed using multi-spectroscopic and molecular docking studies at the protein level. The mechanism of binding of bisphenols with BSA was dynamic in nature. SDS refolding experiments demonstrated no stabilization of BSA structure denatured by BPB, however, BSA denatured by BPA and BPF was found to get stabilized. Also, CD spectra and molecular docking studies revealed that BPB bound more strongly and induced more conformational changes in BSA in comparison to BPA. Hence, this study throws light on the replacement of BPA by its analogues and whether the replacement is associated with a possible risk, raising a doubt that perhaps BPB is not a good substitute of BPA.
journal_name
J Biomol Struct Dynjournal_title
Journal of biomolecular structure & dynamicsauthors
Ikhlas S,Usman A,Ahmad Mdoi
10.1080/07391102.2018.1461136subject
Has Abstractpub_date
2019-04-01 00:00:00pages
1427-1437issue
6eissn
0739-1102issn
1538-0254journal_volume
37pub_type
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journal_title:Journal of biomolecular structure & dynamics
pub_type: 杂志文章
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