Human Microbe-Disease Association Prediction With Graph Regularized Non-Negative Matrix Factorization.

Abstract:

:A microbe is a microscopic organism which may exists in its single-celled form or in a colony of cells. In recent years, accumulating researchers have been engaged in the field of uncovering microbe-disease associations since microbes are found to be closely related to the prevention, diagnosis, and treatment of many complex human diseases. As an effective supplement to the traditional experiment, more and more computational models based on various algorithms have been proposed for microbe-disease association prediction to improve efficiency and cost savings. In this work, we developed a novel predictive model of Graph Regularized Non-negative Matrix Factorization for Human Microbe-Disease Association prediction (GRNMFHMDA). Initially, microbe similarity and disease similarity were constructed on the basis of the symptom-based disease similarity and Gaussian interaction profile kernel similarity for microbes and diseases. Subsequently, it is worth noting that we utilized a preprocessing step in which unknown microbe-disease pairs were assigned associated likelihood scores to avoid the possible negative impact on the prediction performance. Finally, we implemented a graph regularized non-negative matrix factorization framework to identify potential associations for all diseases simultaneously. To assess the performance of our model, cross validations including global leave-one-out cross validation (LOOCV) and local LOOCV were implemented. The AUCs of 0.8715 (global LOOCV) and 0.7898 (local LOOCV) proved the reliable performance of our computational model. In addition, we carried out two types of case studies on three different human diseases to further analyze the prediction performance of GRNMFHMDA, in which most of the top 10 predicted disease-related microbes were verified by database HMDAD or experimental literatures.

journal_name

Front Microbiol

authors

He BS,Peng LH,Li Z

doi

10.3389/fmicb.2018.02560

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

2560

issn

1664-302X

journal_volume

9

pub_type

杂志文章
  • Insights on virulence from the complete genome of Staphylococcus capitis.

    abstract::Staphylococcus capitis is an opportunistic pathogen of the coagulase negative staphylococci (CoNS). Functional genomic studies of S. capitis have thus far been limited by a lack of available complete genome sequences. Here, we determined the closed S. capitis genome and methylome using Single Molecule Real Time (SMRT)...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2015.00980

    authors: Cameron DR,Jiang JH,Hassan KA,Elbourne LD,Tuck KL,Paulsen IT,Peleg AY

    更新日期:2015-09-23 00:00:00

  • Antibiotic Resistance Genes and Bacterial Communities of Farmed Rainbow Trout Fillets (Oncorhynchus mykiss).

    abstract::The rise of antibiotic resistance is not only a challenge for human and animal health treatments, but is also posing the risk of spreading among bacterial populations in foodstuffs. Farmed fish-related foodstuffs, the food of animal origin most consumed worldwide, are suspected to be a reservoir of antibiotic resistan...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.590902

    authors: Helsens N,Calvez S,Prevost H,Bouju-Albert A,Maillet A,Rossero A,Hurtaud-Pessel D,Zagorec M,Magras C

    更新日期:2020-12-03 00:00:00

  • Species-Level Analysis of Human Gut Microbiota With Metataxonomics.

    abstract::The current understanding of human gut microbial community is mainly limited to taxonomic features at the genus level. Here, we examined the human gut microbial community at the species level by metataxonomics. To achieve this purpose, a high-throughput approach involving operational phylogenetic unit analysis of the ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.02029

    authors: Yang J,Pu J,Lu S,Bai X,Wu Y,Jin D,Cheng Y,Zhang G,Zhu W,Luo X,Rosselló-Móra R,Xu J

    更新日期:2020-08-26 00:00:00

  • Prevalence of Antibiotic and Heavy Metal Resistance Determinants and Virulence-Related Genetic Elements in Plasmids of Staphylococcus aureus.

    abstract::The use of antibiotics on a mass scale, particularly in farming, and their release into the environment has led to a rapid emergence of resistant bacteria. Once emerged, resistance determinants are spread by horizontal gene transfer among strains of the same as well as disparate bacterial species. Their accumulation i...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.00805

    authors: Bukowski M,Piwowarczyk R,Madry A,Zagorski-Przybylo R,Hydzik M,Wladyka B

    更新日期:2019-04-24 00:00:00

  • Enhanced Nitrous Oxide Production in Denitrifying Dechloromonas aromatica Strain RCB Under Salt or Alkaline Stress Conditions.

    abstract::Salinity and pH have direct and indirect impacts on the growth and metabolic activities of microorganisms. In this study, the effects of salt and alkaline stresses on the kinetic balance between nitrous oxide (N2O) production and consumption in the denitrification pathway of Dechloromonas aromatica strain RCB were exa...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.01203

    authors: Han H,Song B,Song MJ,Yoon S

    更新日期:2019-06-05 00:00:00

  • Assembly and Succession of Iron Oxide Microbial Mat Communities in Acidic Geothermal Springs.

    abstract::Biomineralized ferric oxide microbial mats are ubiquitous features on Earth, are common in hot springs of Yellowstone National Park (YNP, WY, USA), and form due to direct interaction between microbial and physicochemical processes. The overall goal of this study was to determine the contribution of different community...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2016.00025

    authors: Beam JP,Bernstein HC,Jay ZJ,Kozubal MA,Jennings Rd,Tringe SG,Inskeep WP

    更新日期:2016-02-15 00:00:00

  • Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut.

    abstract::With the increasing amount of evidence linking certain disorders of the human body to a disturbed gut microbiota, there is a growing interest for compounds that positively influence its composition and activity through diet. Besides the consumption of probiotics to stimulate favorable bacterial communities in the huma...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章,评审

    doi:10.3389/fmicb.2016.00979

    authors: Rivière A,Selak M,Lantin D,Leroy F,De Vuyst L

    更新日期:2016-06-28 00:00:00

  • The polycyclic aromatic hydrocarbon degradation potential of Gulf of Mexico native coastal microbial communities after the Deepwater Horizon oil spill.

    abstract::The Deepwater Horizon (DWH) blowout resulted in oil transport, including polycyclic aromatic hydrocarbons (PAHs) to the Gulf of Mexico shoreline. The microbial communities of these shorelines are thought to be responsible for the intrinsic degradation of PAHs. To investigate the Gulf Coast beach microbial community re...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2014.00205

    authors: Kappell AD,Wei Y,Newton RJ,Van Nostrand JD,Zhou J,McLellan SL,Hristova KR

    更新日期:2014-05-09 00:00:00

  • Serotype Distribution and Antimicrobial Susceptibility of Streptococcus pneumoniae in Pre- and Post- PCV7/13 Eras, Taiwan, 2002-2018.

    abstract::In Taiwan, the 7-valent pneumococcal conjugate vaccine (PCV7) was introduced in 2006 and a PCV13 national childhood catchup program was implemented in 2013. To delineate the trend of serotype distribution and antimicrobial susceptibility following vaccination programs, we investigated a total of 1845 Streptococcus pne...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.557404

    authors: Wu CJ,Lai JF,Huang IW,Shiau YR,Wang HY,Lauderdale TL

    更新日期:2020-10-22 00:00:00

  • Impacts of Fertilization Regimes on Arbuscular Mycorrhizal Fungal (AMF) Community Composition Were Correlated with Organic Matter Composition in Maize Rhizosphere Soil.

    abstract::The understanding of the response of arbuscular mycorrhizal fungi (AMF) community composition to fertilization is of great significance in sustainable agriculture. However, how fertilization influences AMF diversity and composition is not well-established yet. A field experiment located in northeast China in typical b...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2016.01840

    authors: Zhu C,Ling N,Guo J,Wang M,Guo S,Shen Q

    更新日期:2016-11-16 00:00:00

  • Origin, diversity, and maturation of human antiviral antibodies analyzed by high-throughput sequencing.

    abstract::Our understanding of how antibodies are generated and function could help develop effective vaccines and antibody-based therapeutics against viruses such as HIV-1, SARS coronavirus (SARS CoV), and Hendra and Nipah viruses (henipaviruses). Although broadly neutralizing antibodies (bnAbs) against the HIV-1 were observed...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2012.00277

    authors: Prabakaran P,Zhu Z,Chen W,Gong R,Feng Y,Streaker E,Dimitrov DS

    更新日期:2012-08-02 00:00:00

  • Assessing Population Diversity of Brettanomyces Yeast Species and Identification of Strains for Brewing Applications.

    abstract::Brettanomyces yeasts have gained popularity in many sectors of the biotechnological industry, specifically in the field of beer production, but also in wine and ethanol production. Their unique properties enable Brettanomyces to outcompete conventional brewer's yeast in industrially relevant traits such as production ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.00637

    authors: Colomer MS,Chailyan A,Fennessy RT,Olsson KF,Johnsen L,Solodovnikova N,Forster J

    更新日期:2020-04-09 00:00:00

  • Crop Establishment Practices Are a Driver of the Plant Microbiota in Winter Oilseed Rape (Brassica napus).

    abstract::Gaining a greater understanding of the plant microbiota and its interactions with its host plant heralds a new era of scientific discovery in agriculture. Different agricultural management practices influence soil microbial populations by changing a soil's physical, chemical and biological properties. However, the imp...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2017.01489

    authors: Rathore R,Dowling DN,Forristal PD,Spink J,Cotter PD,Bulgarelli D,Germaine KJ

    更新日期:2017-08-09 00:00:00

  • LAM Genes Contribute to Environmental Stress Tolerance but Sensibilize Yeast Cells to Azoles.

    abstract::Lam proteins transport sterols between the membranes of different cellular compartments. In Saccharomyces cerevisiae, the LAM gene family consists of three pairs of paralogs. Because the function of paralogous genes can be redundant, the phenotypes of only a small number of LAM gene deletions have been reported; thus,...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.00038

    authors: Sokolov SS,Vorobeva MA,Smirnova AI,Smirnova EA,Trushina NI,Galkina KV,Severin FF,Knorre DA

    更新日期:2020-01-28 00:00:00

  • Comprehensive Characterization of the Attenuated Double Auxotroph Mycobacterium tuberculosisΔleuDΔpanCD as an Alternative to H37Rv.

    abstract::Although currently available model organisms such as Mycobacterium smegmatis and Mycobacterium bovis Bacillus Calmette-Guérin (BCG) have significantly contributed to our understanding of tuberculosis (TB) biology, these models have limitations such as differences in genome size, growth rates and virulence. However, at...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.01922

    authors: Mouton JM,Heunis T,Dippenaar A,Gallant JL,Kleynhans L,Sampson SL

    更新日期:2019-08-20 00:00:00

  • capB2 Expression Is Associated with Staphylococcus aureus Pathogenicity.

    abstract::CapB2 is recognized as a tyrosine kinase and is likely a vital factor in extracellular polysaccharide synthesis in Staphylococcus aureus, but its pathogenicity function and regulatory mechanism remain obscure. Here, we demonstrate that CapB2 enhances bacterial virulence in a murine model. Mice infected with the wild t...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2017.00184

    authors: Li D,Guo Y,Wang S,Lv J,Qi X,Chen Z,Han L,Zhang X,Wang L,Yu F

    更新日期:2017-02-10 00:00:00

  • Ecological Succession of Sulfur-Oxidizing Epsilon- and Gammaproteobacteria During Colonization of a Shallow-Water Gas Vent.

    abstract::In this study, we integrated geochemical measurements, microbial diversity surveys and physiological characterization of laboratory strains to investigate substrate-attached filamentous microbial biofilms at Tor Caldara, a shallow-water gas vent in the Tyrrhenian Sea. At this site, the venting gases are mainly compose...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.02970

    authors: Patwardhan S,Foustoukos DI,Giovannelli D,Yücel M,Vetriani C

    更新日期:2018-12-06 00:00:00

  • Isolation of Burkholderia sp. HQB-1, A Promising Biocontrol Bacteria to Protect Banana Against Fusarium Wilt Through Phenazine-1-Carboxylic Acid Secretion.

    abstract::Fusarium wilt is a devastating soil-borne fungal disease caused by Fusarium oxysporum f.sp. cubense (Foc). In recent years, some antifungal bacteria have been applied for the prevention and biocontrol of pathogenic fungi. In our study, a bacterial strain HQB-1, isolated from banana rhizosphere soil, was cultured for i...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.605152

    authors: Xu Z,Wang M,Du J,Huang T,Liu J,Dong T,Chen Y

    更新日期:2020-12-10 00:00:00

  • Geochemistry and Microbiology Predict Environmental Niches With Conditions Favoring Potential Microbial Activity in the Bakken Shale.

    abstract::The Bakken Shale and underlying Three Forks Formation is an important oil and gas reservoir in the United States. The hydrocarbon resources in this region are accessible using unconventional oil and gas extraction methods, including horizontal drilling and hydraulic fracturing. However, the geochemistry and microbiolo...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.01781

    authors: Tinker K,Gardiner J,Lipus D,Sarkar P,Stuckman M,Gulliver D

    更新日期:2020-07-30 00:00:00

  • Addition of Riboflavin-Coupled Magnetic Beads Increases Current Production in Bioelectrochemical Systems via the Increased Formation of Anode-Biofilms.

    abstract::Shewanella oneidensis is one of the best-understood model organisms for extracellular electron transfer. Endogenously produced and exported flavin molecules seem to play an important role in this process and mediate the connection between respiratory enzymes on the cell surface and the insoluble substrate by acting as...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.00126

    authors: Arinda T,Philipp LA,Rehnlund D,Edel M,Chodorski J,Stöckl M,Holtmann D,Ulber R,Gescher J,Sturm-Richter K

    更新日期:2019-02-05 00:00:00

  • Bacteriophages Reduce Pathogenic Escherichia coli Counts in Mice Without Distorting Gut Microbiota.

    abstract::We performed a study to (i) investigate efficacy of an Escherichia coli/Salmonella spp./Listeria monocytogenes-targeting bacteriophage cocktail (tentatively named F.O.P.) to reduce a human pathogenic E. coli strain O157:H7 in experimentally infected mice, and (ii) determine how bacteriophages impact the normal gut mic...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.01984

    authors: Dissanayake U,Ukhanova M,Moye ZD,Sulakvelidze A,Mai V

    更新日期:2019-09-10 00:00:00

  • The Combined Effect of Cold and Copper Stresses on the Proliferation and Transcriptional Response of Listeria monocytogenes.

    abstract::Listeria monocytogenes is a foodborne pathogen that can cause severe disease in susceptible humans. This microorganism has the ability to adapt to hostile environmental conditions such as the low temperatures used by the food industry for controlling microorganisms. Bacteria are able to adjust their transcriptional re...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.00612

    authors: Quesille-Villalobos AM,Parra A,Maza F,Navarrete P,González M,Latorre M,Toro M,Reyes-Jara A

    更新日期:2019-03-28 00:00:00

  • Bacillus amyloliquefaciens Ameliorates Dextran Sulfate Sodium-Induced Colitis by Improving Gut Microbial Dysbiosis in Mice Model.

    abstract::Several Bacillus strains exert beneficial effects on the maintenance of intestinal homeostasis and host health. However, whether Bacillus amyloliquefaciens (BA) can improve gut microbial dysbiosis and ameliorate colitis is unknown. Therefore, we conducted the present study to investigate the effects of BA administrati...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.03260

    authors: Cao G,Wang K,Li Z,Tao F,Xu Y,Lan J,Chen G,Yang C

    更新日期:2019-01-08 00:00:00

  • Biosynthesis of CdS Quantum Dots Mediated by Volatile Sulfur Compounds Released by Antarctic Pseudomonas fragi.

    abstract::Previously we reported the biosynthesis of intracellular cadmium sulfide quantum dots (CdS QDs) at low temperatures by the Antarctic strain Pseudomonas fragi GC01. Here we studied the role of volatile sulfur compounds (VSCs) in the biosynthesis of CdS QDs by P. fragi GC01. The biosynthesis of nanoparticles was evaluat...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.01866

    authors: Gallardo-Benavente C,Carrión O,Todd JD,Pieretti JC,Seabra AB,Durán N,Rubilar O,Pérez-Donoso JM,Quiroz A

    更新日期:2019-08-13 00:00:00

  • Antimicrobial food packaging: potential and pitfalls.

    abstract::Nowadays food preservation, quality maintenance, and safety are major growing concerns of the food industry. It is evident that over time consumers' demand for natural and safe food products with stringent regulations to prevent food-borne infectious diseases. Antimicrobial packaging which is thought to be a subset of...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章,评审

    doi:10.3389/fmicb.2015.00611

    authors: Malhotra B,Keshwani A,Kharkwal H

    更新日期:2015-06-16 00:00:00

  • Expanding the Repertoire of Carbapenem-Hydrolyzing Metallo-ß-Lactamases by Functional Metagenomic Analysis of Soil Microbiota.

    abstract::Carbapenemases are bacterial enzymes that hydrolyze carbapenems, a group of last-resort β-lactam antibiotics used for treatment of severe bacterial infections. They belong to three β-lactamase classes based amino acid sequence (A, B, and D). The aim of this study was to elucidate occurrence, diversity and functionalit...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2016.01985

    authors: Gudeta DD,Bortolaia V,Pollini S,Docquier JD,Rossolini GM,Amos GC,Wellington EM,Guardabassi L

    更新日期:2016-12-26 00:00:00

  • An In vitro Study of Bio-Control and Plant Growth Promotion Potential of Salicaceae Endophytes.

    abstract::Microbial communities in the endosphere of Salicaceae plants, poplar (Populus trichocarpa) and willow (Salix sitchensis), have been demonstrated to be important for plant growth promotion, protection from biotic and abiotic stresses, and degradation of toxic compounds. Our study aimed to investigate bio-control activi...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2017.00386

    authors: Kandel SL,Firrincieli A,Joubert PM,Okubara PA,Leston ND,McGeorge KM,Mugnozza GS,Harfouche A,Kim SH,Doty SL

    更新日期:2017-03-13 00:00:00

  • Rescue of mutant fitness defects using in vitro reconstituted designer transposons in Mycoplasma mycoides.

    abstract::With only hundreds of genes contained within their genomes, mycoplasmas have become model organisms for precise understanding of cellular processes, as well as platform organisms for predictable engineering of microbial functions for mission-critical applications. Despite the availability of "whole genome writing" in ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2014.00369

    authors: Karas BJ,Wise KS,Sun L,Venter JC,Glass JI,Hutchison CA 3rd,Smith HO,Suzuki Y

    更新日期:2014-07-23 00:00:00

  • Genomic and Transcriptomic Insights into Calcium Carbonate Biomineralization by Marine Actinobacterium Brevibacterium linens BS258.

    abstract::Calcium carbonate (CaCO3) biomineralization has been investigated due to its wide range of scientific and technological implications, however, the molecular mechanisms of this important geomicrobiological process are largely unknown. Here, a urease-positive marine actinobacterium Brevibacterium linens BS258 was demons...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2017.00602

    authors: Zhu Y,Ma N,Jin W,Wu S,Sun C

    更新日期:2017-04-06 00:00:00

  • Controls on soil microbial community stability under climate change.

    abstract::Soil microbial communities are intricately linked to ecosystem functioning because they play important roles in carbon and nitrogen cycling. Still, we know little about how soil microbial communities will be affected by disturbances expected with climate change. This is a significant gap in understanding, as the stabi...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2013.00265

    authors: de Vries FT,Shade A

    更新日期:2013-09-05 00:00:00