Abstract:
:Cirrhotic patients with ascites are at high risk of developing spontaneous bacterial peritonitis (SBP). After exclusion of patients with acute kidney injury (AKI) or other infections, urinary neutrophil gelatinase-associated lipocalin (NGAL) levels were compared between two matched groups of Egyptian cirrhotic patients with ascites, mostly secondary to hepatitis C infection (98%). Group 1 had SBP (n = 41) and group 2 did not (n = 45). By univariate analysis, urinary-NGAL, high total bilirubin, serum creatinine, international normalised ratio and the Model of End-Stage Liver Disease (MELD) score and low platelet count were all significantly correlated with the presence of SBP, but only urinary-NGAL could independently predict development of SBP (P = 0.001). Urinary-NGAL at a cut-off value of 1225 pg/mL, showed a sensitivity of 95% and a specificity of 76%, and is therefore a most useful tool.
journal_name
Trop Doctjournal_title
Tropical doctorauthors
Fouad TR,Abdelsameea E,Elsabaawy M,Ashraf Eljaky M,Zaki El-Shenawy S,Omar Ndoi
10.1177/0049475519830265subject
Has Abstractpub_date
2019-07-01 00:00:00pages
189-192issue
3eissn
0049-4755issn
1758-1133journal_volume
49pub_type
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