Systemic inflammatory impact of periodontitis on cognitive impairment.

Abstract:

OBJECTIVES:The role in dementia of systemic inflammation derived from periodontal disease is not fully elucidated. The objective of our study was to examine the impact of inflammation on the relationship between periodontitis and cognitive impairment. METHODS:We have designed a case (n = 171) and control (n = 131) study to determine the periodontal health status, grade of cognitive impairment/dementia and systemic inflammation level, the last being measured by analysis of 29 inflammatory biomarkers using multiplex techniques. RESULTS:At the time of sampling, 11 of the 29 inflammatory biomarkers were associated with cognitive impairment in patients with more severe periodontitis. However, the inflammatory response to severe periodontitis was more reduced (lower biomarker concentrations) in cases (with cognitive impairment or dementia) than in (cognitively healthy) controls, an unexpected finding. CONCLUSIONS:Based on these results, we cannot confirm that systemic inflammation derived from periodontal disease plays a relevant role in the aetiology of cognitive impairment.

journal_name

Gerodontology

journal_title

Gerodontology

authors

Gil Montoya JA,Barrios R,Sanchez-Lara I,Ramos P,Carnero C,Fornieles F,Montes J,Santana S,Luna JD,Gonzalez-Moles MA

doi

10.1111/ger.12431

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

11-18

issue

1

eissn

0734-0664

issn

1741-2358

journal_volume

37

pub_type

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