Abstract:
BACKGROUND:The role of microRNAs (miRs) in hormone therapy (HT) is of keen interest in developing biomarkers and treatments for individuals with breast cancer. Although miRs are often moderate regulators under homeostatic conditions, their function is changed more in response to physical activity. OBJECTIVE:This single-blind randomized trial aimed to explore the effect of high-intensity interval training (HIIT) on serum levels of miRs in individuals with early-stage breast cancer undergoing HT. METHODS:Hormone receptor-positive women with breast cancer and healthy women were randomly assigned to a healthy control group (n=15), healthy group with HIIT (n=15), breast cancer group with HT (HT, n=26), and breast cancer group with HT and HIIT (HT+HIIT, n=26). The exercise groups underwent interval uphill walking training on a treadmill 3 times a week for 12weeks. At the end of the study, we analyzed changes in levels of cancer-related miRs (oncomiRs) and tumour suppressor miRs (TSmiRs) in response to the HT and HIIT. RESULTS:In women with breast cancer versus healthy controls, the expression of some oncomiRs was significantly increased - miR-21 (P<0.001), miR-155 (P=0.001), miR-221 (P=0.008), miR-27a (P<0.001), and miR-10b (P=0.007) - and that of some TSmiRs was significantly decreased - miR-206 (P=0.048), miR-145 (P=0.011), miR-143 (P=0.008), miR-9 (P=0.020), and let-7a (P=0.005). Moreover, HT considerably downregulated oncomiRs and upregulated TSmiRs. HIIT for 12weeks with HT significantly decreased the expression of the oncomiRs and significantly increased that of the TSmiRs as compared with HT alone. CONCLUSIONS:HITT could amplify the decrease and/or increase in expression of miRs associated with HT in women with breast cancer. A prospective trial could determine whether the use of circulating miRs for monitoring treatment can be useful in therapy decisions. TRIAL REGISTRATION:Iranian Registry of Clinical Trials (No.: IRCT201202289171N1).
journal_name
Ann Phys Rehabil Medjournal_title
Annals of physical and rehabilitation medicineauthors
Alizadeh S,Isanejad A,Sadighi S,Khalighfard S,Alizadeh AMdoi
10.1016/j.rehab.2019.07.001subject
Has Abstractpub_date
2019-09-01 00:00:00pages
329-335issue
5eissn
1877-0657issn
1877-0665pii
S1877-0657(19)30108-3journal_volume
62pub_type
杂志文章,随机对照试验abstract:OBJECTIVE:The main objective of this study was to describe the distribution of referrals offered to patients assessed in the "Post-Acute Stroke program" of Bordeaux University Hospital (France). This program was developed in 2008 to organize the dispensation of care in rehabilitation units specialized in neurological d...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章
doi:10.1016/j.rehab.2016.02.003
更新日期:2016-09-01 00:00:00
abstract::Sacroiliac joint (SIJ) is an uncommon localisation of osteoarthritis. Instability of this joint is one of rare aetiologies. It can occur after resection of the pubic symphysis for whatever the reason. The biomechanical consequences on the SIJ are increasing shear forces and vertical restrain. This leads to secondary p...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章
doi:10.1016/j.rehab.2009.03.002
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND:In a survey of 100 transtibial amputees (TTA) in the study place, it was noticed that nearly 30% of total activities performed by crutches. It was recorded nearly 52% of the amputees were totally independent, 39% had to use a crutch or cane and only 9% need not used any devices simply because they are unawar...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章
doi:10.1016/j.rehab.2012.02.006
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:Constraint-induced movement therapy (CIMT) is increasingly recognized as an effective therapy for children with hemiparesis. However, the effectiveness of CIMT outside the standard rehabilitation protocol in clinical settings is less known. The aim of this systematic review was to investigate the effectivene...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章,评审
doi:10.1016/j.rehab.2017.10.004
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:About two-thirds of stroke patients present long-term upper-limb impairment and limitations of activity, which constitutes a challenge in rehabilitation. This situation is particularly true in developing countries, where there is a need for inexpensive rehabilitation solutions. OBJECTIVE:This study assessed...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章
doi:10.1016/j.rehab.2020.03.017
更新日期:2020-10-15 00:00:00
abstract:BACKGROUND:Botuloscope is a cohort study supported by a French public grant and aiming to evaluate a 1-year treatment of the post-stroke spastic upper limb with botulinum toxin type A (BoNT-A) in terms of individual satisfaction with respect to personalized goals and quality of life. METHODS:This was an open-label pro...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章,多中心研究
doi:10.1016/j.rehab.2019.06.003
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVES:Focus on the different therapeutic patient education (TPE) programs for stroke survivors found in the literature. Verify their content and efficacy. METHOD:A literature review was conducted by searching for entries from 1966 to 2011 in the Medline and Cochrane Library databases. The references for the accep...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章,评审
doi:10.1016/j.rehab.2012.08.011
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:Evaluation of the effects of 6 weeks of wheelchair endurance training on arterial stiffness in an individual with paraplegia. METHODS:A 22-year-old male patient with complete (ASIA A) paraplegia (T11) was tested before and after training (30 minutes three times per week). Physical performance and cardiorespi...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章
doi:10.1016/j.rehab.2008.11.002
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVES:Previous research suggested isolated associations of physical and psychological factors with fibromyalgia severity. Integration of physical and psychological, experienced and observed, modifiable factors associated with fibromyalgia severity in a single model will reveal therapeutic paths toward less severit...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章
doi:10.1016/j.rehab.2019.06.017
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:To assess with an isokinetic dynamometer the force and endurance of the spinal flexor and extensor muscles in pre-teens or teens aged 11 to 13 and 14 to 16 years with and without low back pain (LBP). METHOD:The control group and the LBP group were homogeneous in terms of age, weight, height and Body Mass Ind...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章
doi:10.1016/j.rehab.2013.10.004
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:People who survive severe brain damage may eventually develop a prolonged consciousness disorder. Others can regain full consciousness but remain unable to speak or move because of the severity of the lesions, as for those with locked-in syndrome (LIS). Brain-computer interface techniques can be useful to di...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章
doi:10.1016/j.rehab.2019.02.005
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:There are no handbook or recommendations for the use of pharmacological agents to treat neurobehavioral disorders after traumatic brain injury (TBI). This work proposes a systematic review of the literature and a user guide on neuroleptics, antidepressants, beta-blockers, mood stabilizers and other medication...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章,实务指引,评审
doi:10.1016/j.rehab.2015.10.003
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVE:Compare the clinical outcomes of different knee braces in the early phase of rehabilitation after anterior cruciate ligament reconstruction (ACLR) in athletes. MATERIALS AND METHODS:We conducted a retrospective database study of athletes during early rehabilitation in a tertiary referral hospital between 1 F...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章
doi:10.1016/j.rehab.2017.02.001
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Recent studies reported that wearable sensor devices show low validity for assessing the amount of energy expenditure in individuals after stroke. OBJECTIVE:We aimed to evaluate the validity of energy expenditure calculation based on the product of energy cost and walked distance estimated by wearable devic...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章
doi:10.1016/j.rehab.2019.07.002
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVES:To specify outcomes and identify prognostic factors of neurologic and functional recovery in patients with an acute traumatic spinal cord injury (SCI) associated with cervical spinal canal stenosis (SCS), without spinal instability. METHODS:A retrospective study was conducted using data from a Regional Depa...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章
doi:10.1016/j.rehab.2017.09.003
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Upper-limb robotic-assisted therapy (RAT) is promising for stroke rehabilitation, particularly in the early phase. When RAT is provided as partial substitution of conventional therapy, it is expected to be at least as effective or might be more effective than conventional therapy. Assessments have usually be...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.rehab.2019.04.002
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:Chronic pain is very frequent after spinal cord injury, recent data showing that at least 80% of the patients experience pain, one-third at a severe level. The main objective of the present work is to report and discuss data regarding tools and procedures for the screening, diagnosis, and evaluation of neurop...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 共识发展会议,杂志文章,实务指引
doi:10.1016/j.rehab.2008.12.012
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVES:The pre-return-to-work medical consultation during sick leave for low back pain (LBP) aims at assessing the worker's ability to resume working without risk for his/her health, and anticipating any difficulties inherent to returning to work and job retention. This article summarizes the good practices guideli...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章,评审
doi:10.1016/j.rehab.2015.08.001
更新日期:2015-10-01 00:00:00
abstract:UNLABELLED:Osteoporosis is a common complication in children with motor impairments. They have a higher risk of fractures (20% during their lifetime) mostly at femoral level. Furthermore, these children have pain yet no clear relation has been established between osteoporosis and pain. The efficacy of bisphosphonates h...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章
doi:10.1016/j.rehab.2011.07.002
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVES:To describe the frequency with which members of the French general population in the 30-to-69 age class sought care for lower back pain (LBP) from various healthcare professionals and to identify associated parameters. MATERIAL AND METHODS:Data were collected in the 2002-2003 Décennale Santé survey, which i...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章
doi:10.1016/j.rehab.2010.03.006
更新日期:2010-05-01 00:00:00
abstract:INTRODUCTION:The non pharmacological approach is an important issue in the treatment of psychological and behavioural disorders in traumatic brain injury (TBI) patients. It remains nevertheless insufficiently known and defined. The objective of this work was to develop precise recommendations for caregivers and relativ...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章,评审
doi:10.1016/j.rehab.2015.12.001
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVE:To evaluate simple, measurable indicators of optimal organizational procedures for the hospital-to-home discharge of dependent patients. MATERIAL AND METHOD:All the general practitioners (GPs) in the Maine-et-Loire county of France were sent a questionnaire asking them to rank the three main criteria (from t...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章
doi:10.1016/j.rehab.2011.08.002
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVES:The Leisure Time Physical Activity Questionnaire (LTPAQ) measures the duration of physical activities performed during the past 7 days, and results are expressed in minutes. This study aimed to translate this questionnaire into Canadian-French and to evaluate the content validity and its test-retest reliabil...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章
doi:10.1016/j.rehab.2018.12.002
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to analyze the prevalence of claw toes and its correlation to other lower limb disorders as well as the global functional recovery in a population of hemiplegic patients 1year post-stroke. PATIENTS AND METHODS:This prospective study included 39 stroke patients hospitalized in the Ph...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章
doi:10.1016/j.rehab.2009.12.005
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVES:To investigate the prevalence of pregnancy-related low back pain (PRLBP) in women in Turkey, identify the factors associated with PRLBP and predict the risk of PRLBP. MATERIALS AND METHODS:This cross-sectional study included a total of 1500 pregnant women admitted to a prenatal care clinic in a secondary ca...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章
doi:10.1016/j.rehab.2017.09.005
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Patients with back pain can show one or more features of spinal osteoarthritis (OA), such as morning stiffness, limited or painful range of motion (ROM), and lumbar disc degeneration (LDD). However, it has not been investigated whether these features are prognostic of long-term back pain. OBJECTIVES:This st...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章
doi:10.1016/j.rehab.2020.07.010
更新日期:2020-08-27 00:00:00
abstract:OBJECTIVE:The Osteoarthritis Quality of Life scale (OAQoL) is an osteoarthritis-specific measure developed in the United Kingdom by a needs-based approach. This study describes the adaptation and validation of this English scale into French. METHODS:The OAQoL was translated into French by a dual-panel technique follow...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章
doi:10.1016/j.rehab.2015.09.003
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to analyze the effect of running retraining on the recovery of the knee's functional and muscular properties after anterior cruciate ligament (ACL) reconstruction. METHODS:Eighty-five athletes who had undergone ACL reconstruction surgery were selected randomly to receive, or not to ...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.rehab.2009.12.006
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVES:Piriformis Muscle Syndrome (PMS) is caused by sciatic nerve compression in the infrapiriformis canal. However, the pathology is poorly understood and difficult to diagnose. This study aimed to devise a clinical assessment score for PMS diagnosis and to develop a treatment strategy. MATERIAL AND METHODS:Two ...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 临床试验,杂志文章
doi:10.1016/j.rehab.2013.04.003
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVES:Analyzing the literature and elaborating recommendations on the following topics: relevance of dorsal root entry zone (DREZ) lesions, surgical treatment for posttraumatic syringomyelia, other therapeutic approaches (peripheral nerve root pain, nerve trunk pain and Sign Posterior Cord [SCI] pain). MATERIAL A...
journal_title:Annals of physical and rehabilitation medicine
pub_type: 共识发展会议,杂志文章
doi:10.1016/j.rehab.2008.12.016
更新日期:2009-03-01 00:00:00