Abstract：
:Session V of the Colloquium was chaired by Professors Teresa López-Fernández of Spain and Grzegorz Opolski of Poland. The 3 speakers addressed cardio-oncology issues as they relate to both clinical studies and real life situations. Professor Susan Dent discussed cardio-oncology networks for patients, emphasizing the importance of establishing a framework where the expertise of the cardiology consultant can supplement and reinforce the goals of optimal cancer therapy. Professor Thomas Suter moved the discussion further, sharing his insight into cardiac monitoring in clinical trials, emphasizing the lack of uniform criteria and lack of consensus regarding reversibility of cardiac events and long-term implications of modest declines in systolic function frequently found in clinical trials for which long-term follow-up may not be a component of the trial. Professor Giorgio Minotti added important considerations to the discussion of clinical trials. He emphasized that the usual reporting of cardiac systolic function omits important diastolic dysfunction data generated but often ignored during the routine cardiac exams. The inclusion of cardiac biomarker changes would also help to broaden the perspective of cardiac effects and events seen in patients enrolled in clinical trials.
journal_name
Semin Oncoljournal_title
Seminars in oncologyauthors
Dent SF,Suter TM,López-Fernández T,Opolski G,Menna P,Minotti Gdoi
10.1053/j.seminoncol.2019.01.004subject
Has Abstractpub_date
2019-12-01 00:00:00pages
421-425issue
6eissn
0093-7754issn
1532-8708pii
S0093-7754(19)30006-5journal_volume
46pub_type
abstract：:Topotecan (Hycamtin; SmithKline Beecham Pharmaceuticals, Philadelphia, PA) a new chemotherapeutic agent for the treatment of patients with advanced carcinoma of the ovary after failure of initial or subsequent therapy, is a specific, potent inhibitor of the enzyme topoisomerase I. Myelosuppression is the dose-limiting...
journal_title：Seminars in oncology
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doi：
更新日期：1997-02-01 00:00:00
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journal_title：Seminars in oncology
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doi：
更新日期：2000-02-01 00:00:00
abstract：:Navelbine (NVB) or 5' nor-anhydro-vinblastine was shown to present a broader antitumor activity and to induce fewer side effects than vinblastine (VBL) or vincristine (VCR). The possible mechanisms of these differences were analyzed with in vitro methods. At substoichiometric concentrations, the three drugs inhibit mi...
journal_title：Seminars in oncology
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更新日期：1989-04-01 00:00:00
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journal_title：Seminars in oncology
pub_type： 杂志文章,评审
doi：
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journal_title：Seminars in oncology
pub_type： 杂志文章,评审
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journal_title：Seminars in oncology
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journal_title：Seminars in oncology
pub_type： 杂志文章,评审
doi：
更新日期：1990-04-01 00:00:00
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pub_type： 临床试验,杂志文章
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journal_title：Seminars in oncology
pub_type： 杂志文章
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更新日期：2018-06-01 00:00:00
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journal_title：Seminars in oncology
pub_type： 杂志文章,评审
doi：
更新日期：1989-12-01 00:00:00
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journal_title：Seminars in oncology
pub_type： 杂志文章,评审
doi：
更新日期：2000-12-01 00:00:00
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journal_title：Seminars in oncology
pub_type： 临床试验,杂志文章
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更新日期：1997-08-01 00:00:00
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journal_title：Seminars in oncology
pub_type： 杂志文章,评审
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journal_title：Seminars in oncology
pub_type： 临床试验,杂志文章
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