Viable Pregnancy in a patient with metastatic melanoma treated with double checkpoint immunotherapy.

Abstract:

:Metastatic cancers during pregnancy have historically been associated with dismal outcomes, with greater rates of tumor progression in part because of diminished treatment alternatives. Immunotherapy with T-cell checkpoint inhibitors has significantly impacted the survival of several metastatic tumors. However, given their mechanism of action, immune-related adverse events can occur, especially with combined immunotherapy treatments. During pregnancy, checkpoint pathways have a major role, providing immune tolerance to the fetal allograft. Furthermore, evidence suggests that inhibition of this pathway may be associated with an increased risk of miscarriage. We describe, to our knowledge, the first case reported in the literature of a patient 7 weeks pregnant, diagnosed with metastatic melanoma and treated with nivolumab plus ipilimumab. We also present the associated immune-related side effects and their treatment, as well as the oncologic results that lead to favorable pregnancy outcome.

journal_name

Semin Oncol

journal_title

Seminars in oncology

authors

Burotto M,Gormaz JG,Samtani S,Valls N,Silva R,Rojas C,Portiño S,de la Jara C

doi

10.1053/j.seminoncol.2018.03.003

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

164-169

issue

3

eissn

0093-7754

issn

1532-8708

pii

S0093-7754(17)30193-8

journal_volume

45

pub_type

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