Abstract:
:Choice of network topology for gene regulation has been a question of interest for a long time. How do simple and more complex topologies arise? In this work, we analyze the topology of the marRAB operon in Escherichia coli, which is associated with control of expression of genes associated with conferring resistance to low-level antibiotics to the bacterium. Among the 2102 promoters in E. coli, the marRAB promoter is the only one that encodes for an autoactivator and an autorepressor. What advantages does this topology confer to the bacterium? In this work, we demonstrate that, compared to control by a single regulator, the marRAB regulatory arrangement has the least control cost associated with modulating gene expression in response to environmental stimuli. In addition, the presence of dual regulators allows the regulon to exhibit a diverse range of dynamics, a feature that is not observed in genes controlled by a single regulator.
journal_name
Biophys Jjournal_title
Biophysical journalauthors
Prajapat MK,Jain K,Saini Sdoi
10.1016/j.bpj.2015.08.017subject
Has Abstractpub_date
2015-10-06 00:00:00pages
1497-508issue
7eissn
0006-3495issn
1542-0086pii
S0006-3495(15)00828-0journal_volume
109pub_type
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