Abstract：
:Skeletal muscle responds to endurance exercise with an improvement of biochemical pathways that support substrate supply and oxygen-dependent metabolism. This is reflected by enhanced expression of associated factors after exercise and is specifically modulated by tissue perfusion and oxygenation. We hypothesized that transcript expression of pro-angiogenic factors (VEGF, tenascin-C, Angpt1, Angpt1R) and oxygen metabolism (COX4I1, COX4I2, HIF-1α) in human muscle after an endurance stimulus depends on vasoconstriction, and would be modulated through angiotensin-converting enzyme inhibition by intake of lisinopril. Fourteen non-specifically trained, male Caucasians subjects, carried out a single bout of standardized one-legged bicycle exercise. Seven of the participants consumed lisinopril in the 3 days before exercise. Biopsies were collected pre- and 3 h post-exercise from the m. vastus lateralis. COX4I1 (P = 0.03), COX4I2 (P = 0.04) mRNA and HIF-1α (P = 0.05) mRNA and protein levels (P = 0.01) showed an exercise-induced increase in the group not consuming the ACE inhibitor. Conversely, there was a specific exercise-induced increase in VEGF transcript (P = 0.04) and protein levels (P = 0.03) and a trend for increased tenascin-c transcript levels (P = 0.09) for subjects consuming lisinopril. The observations indicate that exercise-induced expression of transcripts involved in angiogenesis and mitochondrial energy metabolism are to some extent regulated via a hypoxia-related ACE-dependent mechanism.
journal_name
Scand J Med Sci Sportsjournal_title
Scandinavian journal of medicine & science in sportsauthors
van Ginkel S,Ruoss S,Valdivieso P,Degens H,Waldron S,de Haan A,Flück Mdoi
10.1111/sms.12572subject
Has Abstractpub_date
2016-10-01 00:00:00pages
1180-7issue
10eissn
0905-7188issn
1600-0838journal_volume
26pub_type
杂志文章abstract：:During whole-body exercise, peak fat oxidation occurs at a moderate intensity. This study investigated whole-body peak fat oxidation in untrained and trained subjects, and the presence of a relation between skeletal muscle oxidative enzyme activity and whole-body peak fat oxidation. Healthy male subjects were recruite...
journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/j.1600-0838.2005.00480.x
更新日期：2006-06-01 00:00:00
abstract：:This study investigated the relationship between delayed-onset muscle soreness and other indicators of muscle damage following eccentric exercise. Male students (n = 110) performed 12 (12ECC), 24 (24ECC), or 60 maximal eccentric actions of the elbow flexors (60ECC). Maximal isometric force, relaxed and flexed elbow jo...
journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1034/j.1600-0838.2002.10178.x
更新日期：2002-12-01 00:00:00
abstract：:The modified International Knee Documentation Committee Subjective Knee Form (Pedi-IKDC) is a widely used patient-reported tool ranging on a scale from 0 to 100. We aimed to translate Pedi-IKDC into Danish and assess its reproducibility and responsiveness in children with knee disorders. The translation complied with ...
journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/sms.12589
更新日期：2016-12-01 00:00:00
abstract：:Muscle function was evaluated in 40 patients with patellofemoral pain syndrome (PFPS) and 20 healthy controls. Patients with PFPS had a significantly lower knee extensor strength in the most symptomatic knee compared to the least symptomatic knee. Further, the patients had less vertical jumping ability and were weaker...
journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
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更新日期：1995-08-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/sms.13095
更新日期：2018-09-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章,随机对照试验
doi：10.1111/sms.12885
更新日期：2018-01-01 00:00:00
abstract：:A bi-directional bicycle pedal that combines proprioceptive training and evertor strengthening has been developed for the treatment of residual instability after ankle sprains. A prospective randomized study was carried out on 19 subjects with recurrent ankle sprains and positive stress X-ray films. The subjects were ...
journal_title：Scandinavian journal of medicine & science in sports
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2003-08-01 00:00:00
abstract：:Considering their potential relevance for low-back pain, we investigated trunk muscle strength, sagittal lumbo-pelvic alignment while standing and lumbo-pelvic ratio during trunk flexion in adolescent athletes with regard to the effects of age and sex. Twenty-two early adolescent (EA: 13-15 years, 10 females) and 28 l...
journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/sms.13503
更新日期：2019-11-01 00:00:00
abstract：:The present special issue of Scandinavian Journal of Medicine & Science in Sports deals with health and fitness benefits of regular participation in small-sided football games. One review article and 13 original articles were the result of a 2-year multi-center study in Copenhagen and Zurich and include studies of dif...
journal_title：Scandinavian journal of medicine & science in sports
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更新日期：2010-04-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/sms.12826
更新日期：2017-08-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/sms.12934
更新日期：2018-02-01 00:00:00
abstract：:In military operations, declined physical capacity can endanger the life of soldiers. During special support and reconnaissance (SSR) missions, Special Forces soldiers sustain 1-2 weeks full-body horizontal immobilization, which impairs muscle strength and performance. Adequate muscle mass and strength are necessary i...
journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/sms.12170
更新日期：2015-04-01 00:00:00
abstract：:The control region of mitochondrial DNA (mtDNA) contains the main regulatory elements for mtDNA replication and transcription. Certain polymorphisms in this region would, therefore, contribute to elite athletic performance, because mitochondrial function is one of determinants of physical performance. The present stud...
journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/j.1600-0838.2011.01424.x
更新日期：2013-10-01 00:00:00
abstract：:Few studies have examined the possibility that pre- and post-natal factors may be non-linearly associated with later physical activity. We used data from the Norwegian Mother, Father and Child Cohort study (MoBa) and the Medical Birth Registry of Norway (MBRN), including 48 672 children with available data on leisure ...
journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/sms.13781
更新日期：2020-11-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/sms.12272
更新日期：2015-08-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/j.1600-0838.2009.00933.x
更新日期：2010-02-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/j.1600-0838.2006.00616.x
更新日期：2007-12-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章,meta分析,评审
doi：10.1111/sms.12899
更新日期：2018-03-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/sms.12578
更新日期：2016-11-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/sms.13396
更新日期：2019-06-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
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更新日期：2020-01-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/j.1600-0838.2007.00765.x
更新日期：2009-02-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
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更新日期：1996-08-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/j.1600-0838.2006.00570.x
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abstract：:Student-athletes who strive for success in high-level sports while pursuing upper secondary education may be prone to sport and school burnout. This study examined the co-developmental dynamic of sport and school burnout in Finnish adolescent student-athletes (Ntime 1 = 391; Ntime 2 = 373) across the first year of u...
journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/sms.13073
更新日期：2018-06-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/sms.12344
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/sms.13273
更新日期：2018-12-01 00:00:00
abstract：:The aim of the present study was to examine the associations between adaptive responses to an in-season soccer training camp in the heat and changes in submaximal exercising heart rate (HRex, 5-min run at 9 km/h), postexercise HR recovery (HRR) and HR variability (HRV). Fifteen well-trained but non-heat-acclimatized ...
journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/j.1600-0838.2011.01378.x
更新日期：2011-12-01 00:00:00
abstract：:Patellar tendinopathy (PT) is a common overuse injury of the patellar tendon in jumping athletes. In a recent large cross-sectional study from 2008 several factors were identified that may be associated with the etiology of PT. However, because of the study design no conclusions could be drawn about causal relations. ...
journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/sms.12294
更新日期：2015-10-01 00:00:00
