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Adverse Cardiovascular Response to Aerobic Exercise Training: Is This a Concern?

Abstract：

PURPOSE:Aerobic exercise training in sedentary individuals improves physical fitness and various cardiovascular (CV) biomarkers. Nevertheless, there has been controversy as to whether exercise training may adversely affect some biomarkers in a small segment of the population. The purpose of this study was to investigate whether clinically significant worsening of CV biomarkers was more prevalent among individuals randomized to a supervised endurance training program as compared with those randomized to a control condition. METHODS:Baseline and end of study measurements of fasting insulin (FI), triglycerides (TG), resting systolic blood pressure (SBP), and HDL cholesterol (HDL-C) were obtained on 1188 healthy sedentary subjects from 4 clinical studies. Each study randomized subjects to 4- to 6-month supervised aerobic exercise programs or to a control group of no supervised exercise training. For each of the 4 CV biomarkers, we calculated the respective proportions of control and exercise group subjects whose baseline-to-follow-up changes were greater than or equal to previously reported adverse change (AC) thresholds. Those thresholds were increases of 24 pmol · L(-1) or greater for FI, 0.42 mmol · L(-1) or greater for TG, 10 mm Hg or greater for SBP, and a decrease of 0.12 mmol · L(-1) or greater for HDL-C. RESULTS:The respective proportions of subjects meeting the AC threshold in the control and exercise groups were 15.2% versus 9.6% (P = 0.02) for FI, 14.9% versus 13.1% (P = 0.37) for TG, 16.9% versus 15.8% (P = 0.52) for SBP, and 28.6% versus 22.5% (P = 0.03) for HDL-C. All were nonsignificant at the 0.0125 Bonferroni threshold adjusting for multiple comparisons. CONCLUSIONS:These findings do not support the concept that aerobic exercise training increases the risk of adverse changes in the CV biomarkers we studied.

journal_name

Med Sci Sports Exerc

journal_title

Medicine and science in sports and exercise

authors

Leifer ES,Mikus CR,Karavirta L,Resnick BD,Kraus WE,Häkkinen K,Earnest CP,Fleg JL

doi

10.1249/MSS.0000000000000752

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

20-5

issue

eissn

0195-9131

issn

1530-0315

journal_volume

pub_type

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Adverse Cardiovascular Response to Aerobic Exercise Training: Is This a Concern?