Abstract:
BACKGROUND:Previous studies have suggested that interleukin (IL)-17A is a key factor that contributes to intervertebral disc degeneration (IDD), whereas autophagy has been shown to be a protective mechanism in IDD. However, the relationship between IL-17A and autophagy in IDD remains to be fully elucidated. This study sought to evaluate the association between IL-17 and autophagy and the potential mechanism through which IL-17A affects autophagy in IDD. METHODS:Intervertebral disc specimens were collected from 10 patients with lumbar disc herniation. Human degenerated nucleus pulposus (NP) cells were cultured in the presence or absence of IL-17A treatment. Western blot and monodansylcadaverine staining were used to measure autophagy levels in human degenerated NP cells. Subsequently, phosphatidylinositol 3-kinase (PI3K)/Akt/Bcl-2 pathway inhibitors were used to reveal the potential mechanism. RESULTS:IL-17A treatment inhibited the autophagic activity in human NP cells in a time- and dose-dependent manner. Moreover, monodansylcadaverine staining showed that cells treated with IL-17A had significantly fewer changes in their autophagic vacuoles compared with control-treated cells. After IL-17A treatment, expression levels of PI3K, p-Akt, and Bcl-2 in NP cells were significantly increased. Further assays with PI3K/Akt/Bcl-2 inhibitors revealed that IL-17A suppressed autophagy in NP cells by activating the PI3K/Akt/Bcl-2 signaling pathway. CONCLUSIONS:These data suggest that IL-17A promotes IDD by inhibiting autophagy through activation of the PI3K/Akt/Bcl-2 signaling pathway and may offer new insights for targeted therapy of this disease.
journal_name
World Neurosurgjournal_title
World neurosurgeryauthors
He WS,Zou MX,Yan YG,Yao NZ,Chen WK,Li Z,Wang WJ,Ouyang ZHdoi
10.1016/j.wneu.2020.07.117subject
Has Abstractpub_date
2020-11-01 00:00:00pages
e215-e223eissn
1878-8750issn
1878-8769pii
S1878-8750(20)31638-7journal_volume
143pub_type
杂志文章abstract:OBJECTIVE:To determine the optimal proximal fusion level after long instrumented fusion to the sacrum for lumbar degenerative flat back. METHODS:Data from 70 patients with lumbar degenerative flat back were reviewed retrospectively. Three groups were designated according to the upper instrumented vertebrae (UIV): grou...
journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2017.03.051
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Spinal metastatic disease compromises the quality of life and prognosis of the patients. Prognosis is an important factor for the decision-making process and needs to be precise in order to adjust the intensity of therapy. The Tokuhashi score is a universal instrument to determine the prognosis. The objectiv...
journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2017.11.033
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Idiopathic intracranial hypertension (IIH) is characterized by headaches, visual obscurations, and papilledema, and the diagnosis involves lumbar puncture (LP) with an elevated opening pressure (OP) ≥20 cm H20. When papilledema is absent, the diagnosis becomes less clear. Some physicians have argued that the...
journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2017.12.036
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVES:To investigate the biomechanical properties of a novel stabilization method for posterior cervical motion preservation using bioderived freeze-dried tendon. METHODS:Experiments were conducted both in vitro and in vivo. For the in vitro group, 15 fresh-frozen goat spines (C1-C7) were randomly divided into 3 ...
journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2017.07.163
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:To evaluate a new surgical tool combining suction and monopolar neurostimulation (stimulation sucker) for cerebellopontine angle (CPA) tumors. The usefulness for continuous (time) and dynamic (space) facial nerve mapping was studied. METHODS:Patients operated on with the stimulation sucker for a CPA tumor be...
journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2018.07.286
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:Large or giant internal carotid artery (ICA) aneurysms often cause visual deficits and cranial nerve palsy. The aim of this study was to investigate the efficacy of ligation of the ICA with high-flow bypass. METHODS:We retrospectively analyzed the findings from patients with visual deficit and ophthalmologic...
journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2016.10.082
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:Primary central nervous system neuroblastoma (PCNSN) is a rare disease, and its incidence, treatment modalities, and survival remain poorly understood. METHODS:The SEER (Surveillance Epidemiology and End Results) database was used to identify patients diagnosed with PCNSN from 1973 to 2013. The incidence an...
journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2020.04.145
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Therapeutic strategies for managing hemorrhagic moyamoya disease (MMD) remain controversial. In this study, we investigated the optimal therapy for hemorrhagic MMD. METHODS:In accordance with the PRISMA statement, we searched through relevant articles and references from PubMed, Embase, and Cochrane databas...
journal_title:World neurosurgery
pub_type: 杂志文章,meta分析
doi:10.1016/j.wneu.2018.06.076
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:Stiff neck or nuchal rigidity is a significant clinical sign of neurologic disease. It is commonly associated with meningitis, subarachnoid hemorrhage, and posterior fossa tumors. It may also occur as a result of tonsillar impaction following pressure in the infratentorial compartment from an expanding poste...
journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2019.02.230
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVE:Maximal safe resection prolongs the survival of patients with glioblastoma (GB). However, whether total resection of the enhanced lesion is pursued or abandoned depends on preoperative judgments based on the findings of magnetic resonance imaging (MRI). Anatomically, medial temporal tumor tends to invade towa...
journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2019.06.035
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Sedation therapy is vital for treating severe traumatic brain injury (TBI). Yet, types of sedation assessment tools and sedation levels that are suitable for sedation treatment have not been investigated. OBJECTIVE:To investigate the influence of different sedation levels guided by the Bispectral Index (BIS...
journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2017.11.079
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:This meta-analysis of published randomized controlled trials (RCTs) aimed to investigate the efficacy and safety of endovascular therapy (ET) for patients with acute ischemic stroke. METHODS:The summary relative risks (RRs) with corresponding 95% confidence intervals were calculated to measure the effectiven...
journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2020.07.156
更新日期:2020-11-01 00:00:00
abstract::The roots of modern neurosurgery in Iraq can be traced back to the dawn of civilization, the Mesopotamian culture. Archaeological evidence has provided us with new insights regarding Mesopotamian medical practices. Back then, 2 forms of medicine coexisted: therapeutic and divinatory, which were practiced by the Asu an...
journal_title:World neurosurgery
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.wneu.2020.05.097
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:The current literature regarding cranial giant cell tumor (GCT) management includes scattered case reports and small case series. We present a comprehensive literature review and meta-analysis on this subject, along with a case report describing our management of a patient with temporal GCT. METHODS:A syste...
journal_title:World neurosurgery
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.wneu.2016.05.086
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Spontaneous regression in intracranial germ cell tumors (GCTs) is an extremely rare phenomenon with only 9 cases reported. The mechanism and natural history of this phenomenon are still equivocal. METHODS:A 12-year-old boy presented with a lesion in the suprasellar region with involvement of basal ganglia a...
journal_title:World neurosurgery
pub_type: 杂志文章,评审
doi:10.1016/j.wneu.2019.06.220
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:The angioarchitecture and presentation of arteriovenous malformations (AVMs) associated with AVM hemorrhage may vary with patient age. Our aim was to determine the influence of patient age at diagnosis on hemorrhage patterns and outcomes. METHODS:A consecutive case series of 267 cases of ruptured AVMs was r...
journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2015.05.020
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Fenestration of the basilar artery is a segmental duplication of the vessel due to nonfusion of the embryonal arteries and is the second most common vascular disjunction. Here, we present a single case example demonstrating the utility of the temporary bridging device Comaneci as a new option in the endovasc...
journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2018.08.047
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:Reducing complications from unruptured aneurysms (UAs) treatment is important. We clarify the criteria for achieving safe and complete treatment for UAs ≤10 mm by clipping or coil embolization. METHODS:This study included 59 newly treated UAs in the past 2 years. We prospectively decided on criteria to recom...
journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2016.04.005
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Endoscopic surgery for lumbar stenosis is gaining acceptance because of the minimal muscle damage, short recovery times, reduced blood loss, and good clinical results. We report a novel technique of decompressing contralateral traversing and exiting nerve roots through a single interlaminar window, avoiding ...
journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2018.05.111
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:Direct extracranial-intracranial (EC-IC) bypass is one of the fundamental techniques to prevent recurrent stroke in patients with adult-onset ischemic moyamoya disease. When the standard superficial temporal artery (STA) cannot be used for a graft, the posterior auricular artery (PAA) can be a potential surr...
journal_title:World neurosurgery
pub_type: 杂志文章,评审
doi:10.1016/j.wneu.2017.09.005
更新日期:2017-12-01 00:00:00
abstract::Abraham Lincoln was the 16(th) President of the United States of America. On April 14, 1865, shortly after his re-election and the conclusion of the Civil War, Lincoln was shot and killed by John Wilkes Booth. Although numerous physicians tended to the President shortly after his injury, he passed away the next mornin...
journal_title:World neurosurgery
pub_type: 传,历史文章,杂志文章,评审
doi:10.1016/j.wneu.2015.06.011
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVE:To report on our experience with the Elekta Extend system, a relocatable frame system used in patients with brain metastases for single-session, hypofractionated, or staged hypofractionated Gamma Knife radiosurgery (GKRS); and the evaluation of its efficacy. METHODS:From March 2014 to September 2016, 856 pat...
journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2018.07.157
更新日期:2018-11-01 00:00:00
abstract::This study documents a risky vascular anatomic orientation that might play an important role in the postoperative hemodynamics following anterior cerebral artery (ACA) revascularization. A 71-year-old woman presented with uncontrollable frequent right lower limb transient ischemic attacks (TIAs) attributed to a left c...
journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2016.09.023
更新日期:2016-12-01 00:00:00
abstract::From their origins as cardiovascular research tools, endovascular techniques have evolved to provide a minimally invasive means of diagnosis and therapy for individuals suffering from occlusive artery disease. The techniques were pioneered by William Harvey, whose work set the stage for all subsequent endovascular exp...
journal_title:World neurosurgery
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.wneu.2020.01.072
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to examine the clinical effect of postoperative hyperbaric oxygen (HBO) therapy on symptoms and signs in the ventriculoperitoneal (VP) shunt insertion treatment of idiopathic normal pressure hydrocephalus (iNPH). METHODS:We conducted a retrospective analysis of 61 patients treated at...
journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2017.05.003
更新日期:2017-08-01 00:00:00
abstract::There are only three fully trained neurosurgeons to care for Tanzania's population of more than 41 million people. Madaktari was founded in 2006 to serve as a physician training partnership to establish more self-sufficient health care through education and training. Medical students play a valuable role in Madaktari ...
journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2010.05.039
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Although carotid artery stenting (CAS) has been widely acknowledged as an effective alternative option for patients at high risk of carotid endarterectomy, embolic stroke is a major complication of CAS. Several reports have emphasized that distal protection filter alone is associated with a high risk of embo...
journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2020.05.028
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Arteries that anastomose with the posterior inferior cerebellar artery (PICA) can harbor aneurysms. CASE DESCRIPTION:We present a case of a patient who suffered a subarachnoid hemorrhage as a result from an aneurysm on the left lateral spinal artery (LSA) that anastomosed to the PICA. The aneurysm was treat...
journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2018.06.085
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:Large or giant thrombosed intracranial aneurysms (LGTIAs) are highly associated with poor prognosis and remain a challenging disease to treat by either surgery or endovascular treatment (EVT). EVT is considered more difficult for complicated aneurysm like LGTIAs. To understand long-term clinical and angiograp...
journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2020.08.213
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Spindle cell oncocytomas are extremely rare neoplasms of the sellar, parasellar, and suprasellar regions that can frequently mimic pituitary adenomas. Fewer than 50 cases have been ever reported in the literature, and there is no consensus on best treatments to be provided. CASE DESCRIPTION:We hereby presen...
journal_title:World neurosurgery
pub_type: 杂志文章,评审
doi:10.1016/j.wneu.2020.05.255
更新日期:2020-10-01 00:00:00