Abstract:
PURPOSE:To investigate: (1) the cross-sectional association between polypharmacy, hyperpolypharmacy and presence of prefrailty or frailty; (2) the risk of incident prefrailty or frailty in persons with polypharmacy, and vice versa. METHODS:A systematic review and meta-analysis was performed according to PRISMA guidelines. We searched PubMed, Web of Science, and Embase from 01/01/1998 to 5/2/2018. Pooled estimates were obtained through random effect models and Mantel-Haenszel weighting. Homogeneity was assessed with the I2 statistic and publication bias with Egger's and Begg's tests. RESULTS:Thirty-seven studies were included. The pooled proportion of polypharmacy in persons with prefrailty and frailty was 47% (95% CI 33-61) and 59% (95% CI 42-76), respectively. Increased odds ratio of polypharmacy were seen for prefrail (pooled OR = 1.52; 95% CI 1.32-1.79) and frail persons (pooled OR = 2.62, 95% CI 1.81-3.79). Hyperpolypharmacy was also increased in prefrail (OR = 1.95; 95% CI 1.41-2.70) and frail (OR = 6.57; 95% CI 9.57-10.48) persons compared to robust persons. Only seven longitudinal studies reported data on the risk of either incident prefrailty or frailty in persons with baseline polypharmacy. A significant higher odds of developing prefrailty was found in robust persons with polypharmacy (pooled OR = 1.30; 95% CI 1.12-1.51). We found no papers investigating polypharmacy incidence in persons with prefrailty/frailty. CONCLUSIONS:Polypharmacy is common in prefrail and frail persons, and these individuals are also more likely to be on extreme drug regimens, i.e. hyperpolypharmacy, than robust older persons. More research is needed to investigate the causal relationship between polypharmacy and frailty syndromes, thereby identifying ways to jointly reduce drug burden and prefrailty/frailty in these individuals. PROSPERO REGISTRATION NUMBER:CRD42018104756.
journal_name
Eur Geriatr Medjournal_title
European geriatric medicineauthors
Palmer K,Villani ER,Vetrano DL,Cherubini A,Cruz-Jentoft AJ,Curtin D,Denkinger M,Gutiérrez-Valencia M,Guðmundsson A,Knol W,Mak DV,O'Mahony D,Pazan F,Petrovic M,Rajkumar C,Topinkova E,Trevisan C,van der Cammen TJM,van Mdoi
10.1007/s41999-018-0124-5subject
Has Abstractpub_date
2019-02-01 00:00:00pages
9-36issue
1eissn
1878-7649issn
1878-7657pii
10.1007/s41999-018-0124-5journal_volume
10pub_type
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journal_title:European geriatric medicine
pub_type: 杂志文章
doi:10.1007/s41999-018-0128-1
更新日期:2019-02-01 00:00:00
abstract:PURPOSE:Psychosocial resources have been considered to be associated with survival among frail older adults but the evidence is scarce. The aim was to investigate whether psychosocial resources are related to survival among non-robust community-dwelling older people. METHODS:This is a prospective study with 10- and 18...
journal_title:European geriatric medicine
pub_type: 杂志文章
doi:10.1007/s41999-020-00300-7
更新日期:2020-06-01 00:00:00
abstract:PURPOSE:Geriatric rehabilitation provides effective multidisciplinary treatment for older people who show symptoms of relevant and potentially reversible functional decline. The aim of this study is to provide an overview on structures of geriatric rehabilitation across Europe. METHODS:All European Geriatric Medicine ...
journal_title:European geriatric medicine
pub_type: 杂志文章
doi:10.1007/s41999-019-00273-2
更新日期:2020-04-01 00:00:00
abstract:PURPOSE:To investigate characteristics of dysphagia in the oldest-old population and the effect of aging on swallowing physiology. METHODS:418 (364 men, 54 women) patients who underwent videofluoroscopic swallow study (VFSS) for dysphagia were included. The patients were divided into an older group, group I (60-79 yea...
journal_title:European geriatric medicine
pub_type: 杂志文章
doi:10.1007/s41999-019-00259-0
更新日期:2020-02-01 00:00:00
abstract:Objectives:Antidepressant use has increased in older adults recently. This study examines the trends of antidepressant prescribing by prescription status (continuing vs. new prescriptions). Methods:Data were collected from 2006-2015 National Ambulatory Medical Care Survey (NAMCS), a nationally representative sample of...
journal_title:European geriatric medicine
pub_type: 杂志文章
doi:10.1007/s41999-018-0075-x
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:To review the available literature regarding delirium experiences of family caregivers and healthcare staff, to discuss how caregivers and staff perception can increase delirium detection and to summarize how to address the needs of family caregivers and healthcare providers in delirium care. METHODS:"State of...
journal_title:European geriatric medicine
pub_type: 杂志文章,评审
doi:10.1007/s41999-019-00284-z
更新日期:2020-02-01 00:00:00
abstract::The nursing home sector has seen a disproportionately high number of deaths as part of the COVID-19 pandemic. This reflects, in part, the frailty and vulnerability of older people living in care homes but has also, in part, been a consequence of the failure to include care homes in the systematic planning of a respons...
journal_title:European geriatric medicine
pub_type: 杂志文章
doi:10.1007/s41999-020-00347-6
更新日期:2020-08-01 00:00:00
abstract:PURPOSE:Readmissions are common and complicate recovery after hip fracture. The objective of this study was to study readmission rates, factors associated with readmissions and effects of orthogeriatric liaison service in a setting where patients are discharged typically on the first postoperative day from the operatin...
journal_title:European geriatric medicine
pub_type: 杂志文章
doi:10.1007/s41999-020-00307-0
更新日期:2020-08-01 00:00:00
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journal_title:European geriatric medicine
pub_type: 杂志文章
doi:10.1007/s41999-018-0109-4
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:Multimorbidity and frailty are complex conditions often present in older people. The aim of this study was to identify clusters of chronic diseases in robust and frail individuals and compare sociodemographic and health characteristics between these clusters. METHODS:This cross-sectional study used information...
journal_title:European geriatric medicine
pub_type: 杂志文章
doi:10.1007/s41999-020-00291-5
更新日期:2020-04-01 00:00:00
abstract::[This corrects the article DOI: 10.1007/s41999-018-0038-2.]. ...
journal_title:European geriatric medicine
pub_type: 杂志文章,已发布勘误
doi:10.1007/s41999-018-0054-2
更新日期:2018-01-01 00:00:00