Abstract：
BACKGROUND:Severe immune thrombocytopenia displays a rare side effect of pegylated interferon therapy for Hepatitis C infection. Our aim is to report a case of severe and late onset immune thrombocytopenia due to pegylated interferon treatment that was effectively managed with the anti-CD20 monoclonal antibody Rituximab. DESCRIPTION OF THE CASE:A 27-year-old male, Hepatitis C infected patient, presented with sudden, severe immune thrombocytopenia at the end of a standard 24-week antiviral treatment, as a side effect of pegylated interferon. Platelet count rapidly normalized with Rituximab infusions. CONCLUSION:Rituximab could be a valuable treatment option in pegylated interferon related immune thrombocytopenia, when patients are resistant to conventional treatment or when physicians are reluctant to administer corticosteroids.
journal_name
Hippokratiajournal_title
Hippokratiaauthors
Papakonstantinou I,Poulakidas Isubject
Has Abstractpub_date
2014-10-01 00:00:00pages
370-2issue
4eissn
1108-4189issn
1790-8019journal_volume
18pub_type
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