The GPR 55 agonist, L-α-lysophosphatidylinositol, mediates ovarian carcinoma cell-induced angiogenesis.

abstract：LINKED ARTICLES:This article is part of a themed section on Recent Progress in the Understanding of Relaxin Family Peptides and their Receptors. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.10/issuetoc. ...

journal_title：British journal of pharmacology

authors： Summers RJ

更新日期：2017-05-01 00:00:00

abstract：:1. Rabbit isolated irides were loaded with [3H]-noradrenaline and superfused with Tyrode solution. The inhibition by the muscarinic agonists (+/-)-methacholine and pilocarpine of the [3H]-noradrenaline overflow into the superfusate evoked by field stimulation (pulses of 1 ms duration, 75 mA) was measured as an index o...

journal_title：British journal of pharmacology

authors： Bognar IT,Pallas S,Fuder H,Muscholl E

更新日期：1988-07-01 00:00:00

abstract：:Adrenomedullin (ADM) 2/intermedin (IMD) is a short peptide that belongs to the CGRP superfamily. Although it shares receptors with CGRP, ADM and amylin, ADM2 has significant and unique functions in the cardiovascular system. In the past decade, the cardiovascular effect of ADM2 has been carefully analysed. In this rev...

journal_title：British journal of pharmacology

authors： Zhang SY,Xu MJ,Wang X

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Pancreatic islet transplantation is a promising therapeutic approach for Type 1 diabetes. A major prerequisite for the survival of grafted islets is a rapid revascularization after transplantation. Erythropoietin (EPO), the primary regulator of erythropoiesis, has been shown to promote angiogenes...

journal_title：British journal of pharmacology

authors： Menger MM,Nalbach L,Roma LP,Körbel C,Wrublewsky S,Glanemann M,Laschke MW,Menger MD,Ampofo E

更新日期：2020-04-01 00:00:00

abstract：:1. Ca currents in rat and mouse sensory dorsal root ganglion (DRG) neurones were inhibited by concentrations of (-)-baclofen as low as 1 micron. The proportion of neurones responding to baclofen was low (less than 20%), except in young cultures of neonate rat DRG neurones (3 days in culture), where 86% of the neurones...

journal_title：British journal of pharmacology

authors： Green KA,Cottrell GA

更新日期：1988-05-01 00:00:00

abstract：:1. Sympathetic neurotransmission and noradrenaline content of the tail artery of Wistar rats treated for 7 days with the adenosine antagonist, 1,3-dipropyl-8-sulphophenylxanthine (DPSPX), were examined. 2. Systolic blood pressure of the DPSPX-treated rats (164.0 +/- 2.9 mmHg; n = 6) was significantly greater than sali...

journal_title：British journal of pharmacology

authors： Karoon P,Rubino A,Burnstock G

更新日期：1995-09-01 00:00:00

abstract：:1. The present study was undertaken to determine the mechanism of action of endothelin-1 (ET-1)-induced contraction of the guinea-pig isolated trachea. 2. ET-1 (1 nM-0.3 microM) produces a concentration-dependent contraction of guinea-pig trachea with an EC50 of approximately 25 nM. The combination of the peptidoleuko...

journal_title：British journal of pharmacology

authors： Hay DW,Hubbard WC,Undem BJ

更新日期：1993-11-01 00:00:00

abstract：:1. The irritant fungal terpenoid isovelleral caused protective eye-wiping movements in the rat upon intraocular instillation and showed cross-tachyphylaxis with capsaicin, the pungent principle in hot pepper. 2. Isovelleral induced a dose-dependent calcium uptake by rat dorsal root ganglion neurones cultured in vitro ...

journal_title：British journal of pharmacology

authors： Szallasi A,Jonassohn M,Acs G,Bíró T,Acs P,Blumberg PM,Sterner O

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We determined the effects of treatment with LR-90, an inhibitor of advanced glycation end products, on the mechanical properties of the arterial system in streptozotocin (STZ)-induced diabetic Sprague Dawley rats, using aortic impedance analysis, and further investigated the effects of LR-90 on t...

journal_title：British journal of pharmacology

authors： Satheesan S,Figarola JL,Dabbs T,Rahbar S,Ermel R

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The use of tubulin-binding compounds, which act in part by inhibiting tumour angiogenesis, has become an integral strategy of tumour therapy. Recently, tubulysins were identified as a novel class of natural compounds of myxobacterial origin, which inhibit tubulin polymerization. As these compound...

journal_title：British journal of pharmacology

authors： Rath S,Liebl J,Fürst R,Ullrich A,Burkhart JL,Kazmaier U,Herrmann J,Müller R,Günther M,Schreiner L,Wagner E,Vollmar AM,Zahler S

更新日期：2012-11-01 00:00:00

abstract：:ZK110841 and AH6809, an agonist and an antagonist of prostaglandin DP-receptors on human platelets, were evaluated with a fibroblastic cell line from bovine embryonic trachea (EBTr) which specifically responds to prostaglandin D2 (PGD2). ZK110841, equipotent to PGD2, elevated the adenosine 3':5'-cyclic monophosphate (...

journal_title：British journal of pharmacology

authors： Ito S,Okuda E,Sugama K,Negishi M,Hayaishi O

更新日期：1990-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterized by the selective death of upper and lower motor neurons which ultimately leads to paralysis and ultimately death. Pathological changes in ALS are closely associated with pronounced and progressive changes in mitochondrial mor...

journal_title：British journal of pharmacology

authors： Muyderman H,Chen T

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Here, we have compared the neurochemical profile of three new cathinones, butylone, mephedrone and methylone, in terms of their potential to inhibit plasmalemmal and vesicular monoamine transporters. Their interaction with 5-HT and dopamine receptors and their psychostimulant effect was also stud...

journal_title：British journal of pharmacology

authors： López-Arnau R,Martínez-Clemente J,Pubill D,Escubedo E,Camarasa J

更新日期：2012-09-01 00:00:00

abstract：:1. Sarcolemmal membranes were isolated from normal and from denervated muscles and the specific binding of [125I]-alpha-bungarotoxin to the membranes was determined. 2. Cytosol prepared from either slow (soleus) or fast (extensor digitorum longus) muscle increased the toxin binding. Similar effects were seen with cyto...

journal_title：British journal of pharmacology

authors： Harborne AJ,Smith ME

更新日期：1988-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cannabis extracts and several cannabinoids have been shown to exert broad anti-inflammatory activities in experimental models of inflammatory CNS degenerative diseases. Clinical use of many cannabinoids is limited by their psychotropic effects. However, phytocannabinoids like cannabidiol (CBD), d...

journal_title：British journal of pharmacology

authors： Kozela E,Lev N,Kaushansky N,Eilam R,Rimmerman N,Levy R,Ben-Nun A,Juknat A,Vogel Z

更新日期：2011-08-01 00:00:00

abstract：:1. Regulation of the increase in inositol-1,4,5-trisphosphate (IP3) production and intracellular Ca2+ concentration ([Ca2+]i by protein kinase C (PKC) was investigated in canine cultured tracheal smooth muscle cells (TSMCs). Stimulation of TSMCs by 5-hydroxytryptamine (5-HT) caused an initial transient [Ca2+]i peak fo...

journal_title：British journal of pharmacology

authors： Yang CM,Fen LW,Tsao HL,Chiu CT

更新日期：1997-07-01 00:00:00

abstract：:1. Chronic treatment with low doses of the selective monoamine oxidase (MAO) type B inhibitors selegiline [(-)-deprenyl] and rasagiline, causes elevation in extracellular level of 3,4-dihydroxyphenylethylamine (dopamine) in the rat striatum in vivo (Lamensdorf et al., 1996). The present study was carried out to determ...

journal_title：British journal of pharmacology

authors： Lamensdorf I,Porat S,Simantov R,Finberg JP

更新日期：1999-02-01 00:00:00

abstract：:1. Sodium nitroprusside, S-nitroso-N-acetyl-D,L-penicillamine, Spermine NONOate and DEA NONOate raised cyclic GMP levels in bovine chromaffin cells in a time and concentration dependent manner with different potencies, the most potent being DEA/NO with an EC50 value of 0.38 +/- 0.02 microM. 2. Measurements of NO relea...

journal_title：British journal of pharmacology

authors： Ferrero R,Rodríguez-Pascual F,Miras-Portugal MT,Torres M

更新日期：1999-06-01 00:00:00

abstract：:1 The beta-adrenoceptor agonist isoprenaline normally causes only a small and inconsistent increase in the membrane potential of cells in guinea-pig liver slices, in contrast to the large hyperpolarizations seen with alpha-agonists. However, after a selective alpha-adrenoceptor agonist has been applied, the response t...

journal_title：British journal of pharmacology

authors： Jenkinson DH,Koller K

更新日期：1977-01-01 00:00:00

abstract：:1 The effect of potassium channel opening compounds has been investigated in the smooth muscle of rabbit aorta under Ca-free conditions. Examination of the characteristics of the response has been performed using cromakalim as the prototype compound. 2 In order of potency, Ro 31-6930, cromakalim, minoxidil sulphate an...

journal_title：British journal of pharmacology

authors： Duty S,Weston AH

更新日期：1992-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Sublesional osteoporosis predisposes individuals with spinal cord injury (SCI) to an increased risk of low-trauma fracture. The aim of the present work was to investigate the effect of treatment with resveratrol (RES) on sublesional bone loss in spinal cord-injured rats. EXPERIMENTAL APPROACH:Co...

journal_title：British journal of pharmacology

authors： Wang HD,Shi YM,Li L,Guo JD,Zhang YP,Hou SX

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:An alteration in the communication between the innate and adaptive immune cells is a hallmark of ulcerative colitis (UC). Semaphorin-3E (SEMA3E), a secreted guidance protein, regulates various immune responses. EXPERIMENTAL APPROACH:We investigated the expression of SEMA3E in colonic biopsies of...

journal_title：British journal of pharmacology

authors： Kermarrec L,Eissa N,Wang H,Kapoor K,Diarra A,Gounni AS,Bernstein CN,Ghia JE

更新日期：2019-05-01 00:00:00

abstract：:The processes underpinning post-developmental neurogenesis in the mammalian brain continue to be defined. Such processes involve the proliferation of neural stem cells and neural progenitor cells (NPCs), neuronal migration, differentiation and integration into a network of functional synapses within the brain. Both in...

journal_title：British journal of pharmacology

authors： Prenderville JA,Kelly ÁM,Downer EJ

更新日期：2015-08-01 00:00:00

abstract：:1. In order to explore whether 5-HT4 receptor subtypes exist, we have characterized further the 5-HT4 receptor that mediates tachycardia in the piglet isolated right atrium. All experiments were carried out in the presence of propranolol (400 nM) and cocaine (6 microM). We used tryptamine derivatives, substituted benz...

journal_title：British journal of pharmacology

authors： Medhurst AD,Kaumann AJ

更新日期：1993-11-01 00:00:00

abstract：:1. The possible mechanisms of action of the inhibitory effect of gomisin C on the respiratory burst of rat neutrophils in vitro was investigated. 2. The peptide formyl-Met-Leu-Phe (FMLP) induced superoxide anion (O2-) formation and O2 consumption, which was inhibited by gomisin C in a concentration-dependent manner (I...

journal_title：British journal of pharmacology

authors： Wang JP,Raung SL,Hsu MF,Chen CC

更新日期：1994-11-01 00:00:00

abstract：:1. Many apparent actions of adenosine 5'-triphosphate (ATP) are mediated by adenosine produced by enzymatic hydrolysis of the nucleotide. Previously described actions of ATP in the CNS have been partly due to this phenomenon. In the present study analogues of ATP, which are not hydrolysed to adenosine, were used to se...

journal_title：British journal of pharmacology

authors： Stone TW,Cusack NJ

更新日期：1989-06-01 00:00:00

abstract：:1. The rat spinal cord in vitro has been used to assess the effect of 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) on the dorsal root evoked extracellular ventral root reflex (DR-VRR) and the intracellular excitatory postsynaptic potential (e.p.s.p.) in ventral horn neurones and motoneurones. 2. CNQX (1-5 microM) produ...

journal_title：British journal of pharmacology

authors： King AE,Lopez-Garcia JA,Cumberbatch M

更新日期：1992-10-01 00:00:00

abstract：:1 Depolarizations were recorded intracellularly in smooth muscle from the taenia of the guinea-pig caecum in response to the iontophoretic application of acetylcholine, carbachol, oxotremorine-M, methylfurmethide, hexyl trimethylammonium and tetramethylammonium (TMA). 2 No differences between the iontophoretic respons...

journal_title：British journal of pharmacology

authors： Bolton TB,Clark JP

更新日期：1981-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Psychological stress exacerbates symptoms of urinary bladder dysfunction; however, the underlying brain mechanisms are unclear. We have demonstrated that centrally administered bombesin, a stress-related neuropeptide, facilitates the rat micturition reflex. Brain bombesin-like peptides modulate t...

journal_title：British journal of pharmacology

authors： Shimizu T,Shimizu S,Wada N,Takai S,Shimizu N,Higashi Y,Kadekawa K,Majima T,Saito M,Yoshimura N

更新日期：2017-09-01 00:00:00

abstract：:1. Recent studies demonstrated that inhibition or genetic inactivation of the enzyme poly (ADP-ribose) polymerase (PARP) is beneficial in myocardial reperfusion injury. PARP activation in the reperfused myocardium has been assumed, but not directly demonstrated. Furthermore, the issue whether pharmacological PARP inhi...

journal_title：British journal of pharmacology

authors： Liaudet L,Szabó E,Timashpolsky L,Virág L,Cziráki A,Szabó C

更新日期：2001-08-01 00:00:00