Abstract:
:This study aimed to investigate the correlation between bone mineral density (BMD) with hemoglobin and ferritin levels in Palestinian patients suffering from various types of hemoglobinopathies. The study revealed the thresholds of hemoglobin and ferritin to protect against low BMD in these patients. PURPOSE:Iron overload is the main cause of low BMD in subjects with hemoglobinopathies. We used iron overload-related parameters like hemoglobin and ferritin to estimate the cutoff values required to maintain bone health and identify subjects with low BMD. METHODS:Palestinian patients (135) suffering from various types of hemoglobinopathies were recruited from various medical centers including 87 β thalassemia major (TM), 13 thalassemia intermedia (TI), 16 sickle cell anemia (SCA), 17 sickle cell thalassemia (SCT), and 1 thalassemia trait (TT). Most subjects (84%) were below the age of 30 years. BMD was measured and the z score was used to identify subjects with low BMD (z < - 2.0). Receiver operator characteristic (ROC) curve analysis was used to estimate the thresholds of hemoglobin and ferritin levels needed to protect against low BMD in these patients. RESULTS:No difference in means of age, weight, BMI, hemoglobin, and ferritin levels among the recruited male and female subjects were observed. The results showed that 77% of TM subjects had low BMD levels and femoral neck and total hip BMD were significantly lower among female compared to male subjects. Thalassemia patients (TM, TI, and SCT combined) had significantly low BMD and lower hemoglobin mean values compared to normal BMD subjects (8.54 vs. 9.25 g/dL, p = 0.01). Pearson's correlation analysis showed positive correlation between hemoglobin levels and BMD at the three sites, being higher with lumbar spine (r = 0.444) compared to femoral neck (r = 0.291) and total hip (r = 0.224). Ferritin levels in TM patients (4800 ng/ml) and TI subjects (1500 ng/ml) were abnormally high. ROC curve analysis showed that hemoglobin threshold ≤ 9.3 g/dL represents a risk for developing low BMD with an area under the ROC curve (AUC) 0.699 and sensitivity and specificity were 87.9% and 47.7%, respectively. Similar analysis revealed that Ferritin threshold to protect against low BMD should be maintained below 2300 ng/ml with AUC 0.619 and sensitivity and specificity were 55.0% and 71.4%, respectively. CONCLUSIONS:The results of this study strongly recommend to maintain hemoglobin levels above 9.3 g/dL and ferritin below 2300 ng/ml to protects against low BMD in TM subjects and patients suffering from the other related hemoglobinopathies.
journal_name
Arch Osteoporosjournal_title
Archives of osteoporosisauthors
Kharroubi A,Karmi B,Shamasneh W,Saba Edoi
10.1007/s11657-020-00853-xsubject
Has Abstractpub_date
2020-11-13 00:00:00pages
181issue
1eissn
1862-3522issn
1862-3514pii
10.1007/s11657-020-00853-xjournal_volume
15pub_type
杂志文章abstract:OBJECTIVE:A summary of recommendations is given within the Gulf Cooperation Council (GCC) setting on the assessment and management of vitamin D deficiency in the region. METHODS:An assembly of 11 regional experts gathered to formulate an all-inclusive approach to vitamin D deficiency within GCC. RESULTS AND CONCLUSIO...
journal_title:Archives of osteoporosis
pub_type: 共识发展会议,杂志文章
doi:10.1007/s11657-020-0709-8
更新日期:2020-03-02 00:00:00
abstract::This cross-sectional study among members of public showed that people generally had good knowledge and awareness about vitamin D. However, inconsistencies between awareness and attitudes were observed. Our findings reinforce the need of educating people to improve attitude and practices toward vitamin D consumption. ...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-019-0671-5
更新日期:2019-11-22 00:00:00
abstract::Trabecular bone score, an index of lumbar spine trabecular texture, has not been explored fully in adolescent girls. Our cross-sectional analysis supported the hypothesis that "adult normal" trabecular bone score has been achieved by the end of the first year post-menarche, providing a potential screening tool, indepe...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-017-0388-2
更新日期:2017-10-18 00:00:00
abstract::This study assesses the impact of risk factors for fracture in women aged 80+ and 60-79. The results suggest that risk assessment which fits younger women may not be suited for the 80+ strata as many common risk factors are less predictive in the older compared to the younger cohort. PURPOSE:This study assesses wheth...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-019-0592-3
更新日期:2019-04-08 00:00:00
abstract::In this study, we attempted to determine the epidemiology and clinical characteristics of hip fracture in the elderly. We find that elderly people with hip fracture have multiple comorbidities and suffer numerous complications. INTRODUCTION:We attempted to explore the epidemiology and clinical characteristics of hip ...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-019-0580-7
更新日期:2019-03-12 00:00:00
abstract:UNLABELLED:Osteoporosis is common, and physical activity is important in its prevention and treatment. Of the categories of historical physical activity (PA) examined, we found that weight-bearing and very hard physical activity had the strongest relationships with areal bone mineral density (aBMD) throughout growth an...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-015-0239-y
更新日期:2015-01-01 00:00:00
abstract::While adherence to osteoporosis treatment is low, patients' preference for osteoporosis treatment is unknown in Chinese patients. Chinese patients are willing to receive treatments with higher clinical efficacy and lower out-of-pocket cost. In addition, annual intravenous infusion and 6-month subcutaneous injection ar...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-019-0624-z
更新日期:2019-07-31 00:00:00
abstract::The purpose of this study is to establish the prevalence and determinants of fractures among 974 Lebanese schoolchildren aged 8-18. Fractures might be less common in the Lebanese pediatric population compared to western populations. Male gender and high SES are independent risk factors for fractures, while 25(OH)D and...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-019-0559-4
更新日期:2019-01-15 00:00:00
abstract::One hundred and eighty patients with incident fragility hip fracture admitted to a tertiary care center in Sri Lanka were followed up for 12 months. When compared with those survived, patients who died were older and had higher comorbidity and physical impairment, before fracture and at discharge from the hospital. I...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-020-00769-6
更新日期:2020-06-25 00:00:00
abstract::This study aims to evaluate factors affecting the quality of life (QOL) of hypoparathyroidism. While QOL is reduced in post-surgical and non-surgical groups, mental health seems to be less affected in non-surgical patients. Having an additional disease affects QOL negatively but having thyroid cancer may not change th...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-020-00759-8
更新日期:2020-05-19 00:00:00
abstract::Hip fractures are common in elderly people. Despite great progress in surgical care, the outcomes of these patients remain disappointing. This study determined pre-fracture hospital admission as a prognostic variable for inferior functional outcomes and increased mortality rates in the perioperative phase and in the f...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-017-0327-2
更新日期:2017-12-01 00:00:00
abstract::In a large population-based study of Iran, the age-standardized prevalence of osteoporosis was 24.6% in men and 62.7% in women aged ≥ 60 years. Osteoporosis was negatively associated with body mass index in both sexes, and with diabetes in men and hypertriglyceridemia in women. PURPOSE:Population aging has made osteo...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-020-00872-8
更新日期:2021-01-21 00:00:00
abstract:UNLABELLED:Changes in bed management and access policy aimed to shorten Canadian hip fracture hospital stay. Secular trends in hip fracture total, preoperative, and postoperative stay are unknown. Hip fracture stay shortened from 2004 to 2012, mostly from shortening postoperative stay. This may reflect changes in bed m...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-016-0264-5
更新日期:2016-01-01 00:00:00
abstract:UNLABELLED:Black women are generally regarded as being less prone to the development of osteoporosis. This study reports a similar prevalence of morphometric vertebral fractures in black (9.1 %) and white (5.0 %) South African women. Clinical risk factors and bone strength parameters contributed differently to fracture...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-015-0203-x
更新日期:2015-01-01 00:00:00
abstract::Osteoporosis has become an important health concern even in men. We aimed to analyze its prevalence and associated factors in Korean men. Low socioeconomic status, unhealthy lifestyle, and chronic kidney disease increased the risk. High-risk men even at young age need to evaluate bone mineral density, and proper inter...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-018-0506-9
更新日期:2018-08-20 00:00:00
abstract:UNLABELLED:Different sources were used to estimate the 2010 health care costs of managing low bone density (osteopenia/osteoporosis) plus caring fragility fractures in Mexico at 411 million USD. Figures are projected to rise 42 % by 2020. Preventive and timely interventions are required to decrease the financial burden...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-013-0125-4
更新日期:2013-01-01 00:00:00
abstract:UNLABELLED:Minimal data on bone mineral density changes are available from populations in developing countries. Using calcaneal quantitative ultrasound (QUS) techniques, the current study contributes to remedying this gap in the literature by establishing a normative data set on the indigenous Shuar and non-Shuar Colon...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-011-0056-x
更新日期:2011-01-01 00:00:00
abstract::A hip fracture liaison service that was implemented in 2 hospitals in Alberta, Canada, co-managed by a nurse and physician, was effective for improving initiation of osteoporosis medication following hip fracture. PURPOSE:To examine implementation of an in-patient hip fracture liaison service (H-FLS) to improve osteo...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-020-00751-2
更新日期:2020-06-02 00:00:00
abstract::Our study describes the clinical characteristics of patients with fragility fractures. It also shows there is a low knowledge about osteoporosis and its relation to fractures, in addition to the very poor adherence to medical advice and treatment. INTRODUCTION:Osteoporosis is a systemic skeletal disease associated wi...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-019-0646-6
更新日期:2019-09-05 00:00:00
abstract::In this prospective multicenter study of osteoporotic vertebral fractures (OVFs), delayed union of OVF at 6-month follow-up caused prolonged pain, QOL impairment, ADL impairment, cognitive status deterioration, and vertebral collapse progression. PURPOSE:Delayed union following osteoporotic vertebral fracture display...
journal_title:Archives of osteoporosis
pub_type: 杂志文章,多中心研究
doi:10.1007/s11657-017-0411-7
更新日期:2017-12-28 00:00:00
abstract:UNLABELLED:This study aimed to investigate women's perspectives and experiences with screening for osteoporosis. Focus groups and individual interviews were conducted. Three main themes emerged: knowledge about osteoporosis, psychological aspects of screening, and moral duty. Generally, screening was accepted due to li...
journal_title:Archives of osteoporosis
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11657-014-0192-1
更新日期:2014-01-01 00:00:00
abstract::Hospital care and mortality of diabetic and non-diabetic osteoporotic Asian patients undergoing hip fracture surgery were explored with no difference in length of hospitalization, incidence of post-operative complications, or mortality between diabetics and non-diabetics seen. Time to operation correlated with post-op...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-018-0440-x
更新日期:2018-03-15 00:00:00
abstract::Retrospective and prospective population-based survey in a region of the Republic of Kazakhstan determined the incidence of fractures at the hip, proximal humerus and distal forearm. The hip fracture rates were used to create a FRAX® model to enhance fracture risk assessment in Kazakhstan. OBJECTIVE:This paper descri...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-020-0701-3
更新日期:2020-02-27 00:00:00
abstract::We surveyed 573 physicians in the Middle East regarding osteoporosis management. Sixty percent had access to, but were not in charge of, densitometry reporting. Screening for secondary causes was common; 62% were aware of FRAX®; less than half used it. Medications were accessible, and most participants had concerns re...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-019-0609-y
更新日期:2019-06-07 00:00:00
abstract::Fall prevention is an important way to prevent fractures in person with osteoporosis. We developed and implemented a fall screening program in the context of routine osteoporosis care. This program was found to be feasible and showed that a significant proportion of persons with osteoporosis are at risk of falling. P...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-017-0393-5
更新日期:2017-10-31 00:00:00
abstract:PURPOSE:Management of fracture nonunion is challenging as another surgical intervention for the patient is often a necessity, which has a huge impact on both quality of life and economic burden of the patient. Thus, a less aggressive and better accepted treatment for nonunion is required. METHODS:We gave teriparatide ...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-017-0311-x
更新日期:2017-12-01 00:00:00
abstract::We examined the effect of cumulative exposure to high doses of oral glucocorticoids on fracture risk. Compared to short-course users (daily dose ≥ 15 mg + cumulative < 1 g), heavy users (daily dose ≥ 15 mg + cumulative dose ≥ 1 g) had the highest risk of fracture. These patients should be monitored for fracture manage...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-018-0424-x
更新日期:2018-03-18 00:00:00
abstract::A systematic review and meta-analysis was conducted on the prevalence of osteoporosis in the Eastern Mediterranean Region. The overall pooled prevalence of osteoporosis was 24.4%. The prevalence has increased significantly over the recent years. The highest pooled prevalence was in Saudi Arabia (32.7%), and the lowest...
journal_title:Archives of osteoporosis
pub_type: 杂志文章,meta分析
doi:10.1007/s11657-018-0540-7
更新日期:2018-11-17 00:00:00
abstract::If all adults with osteoporosis in the European Union (EU) and United States (US) used calcium and vitamin D supplements, it could prevent more than 500,000 fractures/year in the EU and more than 300,000/year in the US and save approximately €5.7 billion and US $3.3 billion annually. PURPOSE:Evaluate the cost-effecti...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-019-0589-y
更新日期:2019-04-30 00:00:00
abstract::In the past 10 years after implementation, the orthogeriatric treatment model led in general to consistent outcomes for 1555 older adults in terms of most of the complications and mortality. Surgery was more often delayed to 24-48 h after arrival at the hospital, while the length of hospital stay shortened. INTRODUCT...
journal_title:Archives of osteoporosis
pub_type: 杂志文章
doi:10.1007/s11657-018-0550-5
更新日期:2018-11-19 00:00:00