Abstract：
:Breast cancer (BC) is a common disease that generally occurs in women over the age of 50, and the risk is especially high for women over 60 years of age. One of the major BC therapeutic problems is that tumors initially responsive to chemotherapeutic approaches can progress to more aggressive forms poorly responsive to therapies. Polyamines (PAs) are small polycationic alkylamines, naturally occurring and essential for normal cell growth and development in eukaryotes. The intracellular concentration of PA is maintained within strongly controlled contents, while a dysregulation occurs in BC cells. Polyamines facilitate the interactions of transcription factors, such as estrogen receptors with their specific response element, and are involved in the proliferation of ER-negative and highly invasive BC tumor cells. Since PA metabolism has a critical role in cell death and proliferation, it represents a potential target for intervention in BC. The goal of this study was to perform a literature search reviewing the association between PA metabolism and BC, and the current evidence supporting the BC treatment targeting PA metabolism. We here describe in vitro and in vivo models, as well as the clinical trials that have been utilized to unveil the relationship between PA metabolism and BC. Polyamine pathway is still an important target for the development of BC chemotherapy via enzyme inhibitors. Furthermore, a recent promising strategy in breast anticancer therapy is to exploit the self-regulatory nature of PA metabolism using PA analogs to affect PA homeostasis. Nowadays, antineoplastic compounds targeting the PA pathway with novel mechanisms are of great interest and high social impact for BC chemotherapy.
journal_name
Breast Cancer Res Treatjournal_title
Breast cancer research and treatmentauthors
Cervelli M,Pietropaoli S,Signore F,Amendola R,Mariottini Pdoi
10.1007/s10549-014-3156-7subject
Has Abstractpub_date
2014-11-01 00:00:00pages
233-48issue
2eissn
0167-6806issn
1573-7217journal_volume
148pub_type
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journal_title：Breast cancer research and treatment
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journal_title：Breast cancer research and treatment
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doi：10.1023/a:1006123721205
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/BF01831474
更新日期：1992-01-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章,随机对照试验
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pub_type： 杂志文章,meta分析
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章,评审
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journal_title：Breast cancer research and treatment
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journal_title：Breast cancer research and treatment
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1007/s10549-006-9247-3
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
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journal_title：Breast cancer research and treatment
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journal_title：Breast cancer research and treatment
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journal_title：Breast cancer research and treatment
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
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journal_title：Breast cancer research and treatment
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