Abstract：
INTRODUCTION:This study characterizes ovariectomized (OVX)-induced osteoporotic fracture healing with focus on estrogen receptors (ERs). Callus formation plays a critical role in fracture healing, and ERs are well-known mechanosensors in osteogenic pathways. It was hypothesized that callus formation was related to and partially determined by the difference in expression patterns of ERs in both normal and OVX-induced osteoporotic fractures. METHODS:Closed femoral fracture in SHAM and ovariectomized rats were used in this study. Weekly callus width (CW) and area (CA), endpoint mechanical properties, gene expressions of Col-1, BMP-2, ER-α, ER-β and ER-α:ER-β ratios (ER-ratios), and correlations were assessed at 2, 4 and 8 weeks post-fracture. RESULTS:CW and CA results confirmed that OVX-induced osteoporotic fracture was delayed at 2-4 weeks with impaired endpoint mechanical properties. Gene expressions of ER-α and ER-β were higher in the SHAM group at week 2 (p < 0.05) and later lowered at week 8; whereas the OVX group showed an opposing trend. Moderate correlation existed between ER-α and BMP-2 (0.545, p = 0.003), and ER-ratio and BMP-2 (0.601, p = 0.001), and BMP-2 to CW and CA (r = 0.709, p = 0.000 and r = 0.588, p = 0.001, respectively). ER-α and ER-β proteins expressions were confirmed by immunohistochemistry at the fracture callus in reparative progenitor cells, osteoblasts- and osteoclasts-like cells. CONCLUSION:We conclude that the delayed healing rate and impaired callus quality in OVX-induced osteoporotic fracture is related to the delayed expression of ERs. A high ER-α:ER-β ratio favors callus formation.
journal_name
Arch Orthop Trauma Surgjournal_title
Archives of orthopaedic and trauma surgeryauthors
Chow SK,Leung KS,Qin L,Wei F,Cheung WHdoi
10.1007/s00402-014-2070-0subject
Has Abstractpub_date
2014-10-01 00:00:00pages
1405-16issue
10eissn
0936-8051issn
1434-3916journal_volume
134pub_type
杂志文章abstract：INTRODUCTION:There is a great deal of controversy about the effect of tourniquets on development of deep vein thrombosis (DVT) after total knee arthroplasty (TKA). PATIENTS AND METHODS:We investigated the incidence of postoperative DVT after TKA with or without the use of a tourniquet. The patients were 48 consecutive...
journal_title：Archives of orthopaedic and trauma surgery
pub_type： 杂志文章
doi：10.1007/s00402-006-0244-0
更新日期：2007-10-01 00:00:00
abstract：:An intrathoracic shoulder dislocation is a rare injury, usually the result of high-energy trauma [Hawkes et al. in Am J Orthop 43(4):E74-E78, 2014; Tsai et al. in Ann Thorac Cardiovasc Surg 20:592-594, 2014, in Rupprecht et al. Bull Emerg Trauma 5(3):212-214, 2017; Abellan et al. J Orthop Surg (Hong Kong)18(2):254-257...
journal_title：Archives of orthopaedic and trauma surgery
pub_type： 杂志文章
doi：10.1007/s00402-019-03242-3
更新日期：2020-04-01 00:00:00
abstract：:The biomechanical stability of two compound osteosynthesis techniques with and without intramedullary splinting were compared in 20 paired cadaver femora. Group A was stabilised using a contoured 12-hole DC plate and polymethylmethacrylate cement. In group B an additional intramedullary semi-diameter osteosynthesis pl...
journal_title：Archives of orthopaedic and trauma surgery
pub_type： 杂志文章
doi：10.1007/BF00573454
更新日期：1996-01-01 00:00:00
abstract：:For the athlete a stress fracture of the great toe sesamoid is an injury of fundamental significance. As radiographic findings and bone scintigraphy are not specific, these fractures have the longest delay between first symptoms and definitive diagnosis. Apart from magnetic resonance imaging, the only accurate investi...
journal_title：Archives of orthopaedic and trauma surgery
pub_type： 杂志文章
doi：10.1007/BF00420264
更新日期：1993-01-01 00:00:00
abstract：PURPOSE:To analyze the radiographic and clinical outcomes of deltoid ligament repair, we studied 34 supination external rotation type IV ankle fracture patients with deltoid ruptures who required syndesmosis fixation. METHODS:We retrospectively evaluated 34 cases of ruptured deltoid ligaments with associated supinatio...
journal_title：Archives of orthopaedic and trauma surgery
pub_type： 杂志文章
doi：10.1007/s00402-020-03645-7
更新日期：2020-10-29 00:00:00
abstract：:This case report describes a very rare and highly malignant type of lymphoma, which presents as a mucous cyst on the finger. The cyst was excised and the specimen pathohistologically analyzed. The analysis revealed the presence of a Natural-Killer cell neoplasm. This case illustrates and stresses the importance of a p...
journal_title：Archives of orthopaedic and trauma surgery
pub_type： 杂志文章
doi：10.1007/s00402-008-0794-4
更新日期：2009-12-01 00:00:00
abstract：INTRODUCTION:Superior capsule reconstruction (SCR) has been used for the tendon grafting of massive rotator cuff tears when primary repair is difficult. We examined the postoperative outcomes of SCR for massive rotator cuff tears and the risk factors for postoperative retear. MATERIALS AND METHODS:Through this retrosp...
journal_title：Archives of orthopaedic and trauma surgery
pub_type： 杂志文章
doi：10.1007/s00402-019-03316-2
更新日期：2020-10-01 00:00:00
abstract：:Perthes' disease was originally viewed as a local ischaemic necrosis of the femoral head. Several authors, however, have presented data suggesting that children with this disease also suffer from a general disorder of skeletal maturation. Hormonal changes in the hypothalamus-pituitary-growth plate axis have been discu...
journal_title：Archives of orthopaedic and trauma surgery
pub_type： 杂志文章
doi：10.1007/BF00388093
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND:Intra-articular fractures of the distal radius (DRF) are associated with a twofold increase in the risk of scapholunate ligament injury (SLI). The aim of this study was to compare functional outcome, pain, and disability between patients with operatively treated DRF and either an acute, repaired scapholunate...
journal_title：Archives of orthopaedic and trauma surgery
pub_type： 杂志文章
doi：10.1007/s00402-013-1797-3
更新日期：2013-09-01 00:00:00
abstract：INTRODUCTION:Removal of a cemented femoral stem during revision total hip arthroplasty is a technically demanding procedure that requires a multitude of surgical techniques and tools. To gain full access to the cement and the stem, distal fenestration or a transfemoral approach is often required. This paper presents a ...
journal_title：Archives of orthopaedic and trauma surgery
pub_type： 杂志文章
doi：10.1007/s00402-010-1063-x
更新日期：2010-07-01 00:00:00
abstract：:Local biomechanical factors in the etiology of vertebral compression fractures are reviewed. The vertebral body is particularly vulnerable to compression fracture when its bone mineral density (BMD) falls with age. However, the risk of fracture, and the type of fracture produced, does not depend simply on BMD. Equally...
journal_title：Archives of orthopaedic and trauma surgery
pub_type： 杂志文章,评审
doi：10.1007/s00402-011-1355-9
更新日期：2011-12-01 00:00:00
abstract：INTRODUCTION:Bankart repair laxity may contribute to pathologic joint instability. This biomechanical study compared two screw-in suture anchor-suture combinations under tensile loads. METHODS:Twelve pairs of scapulae were implanted with either a 3 mm diameter, 14 mm long poly-L/D-lactide suture anchor with a suture e...
journal_title：Archives of orthopaedic and trauma surgery
pub_type： 杂志文章
doi：10.1007/s00402-009-0926-5
更新日期：2010-03-01 00:00:00
abstract：:Four hundred and thirty femoral trochanteric fractures operated with nail-plate (McLaughlin), Ender, or sliding screw-plate (Richard) osteosynthesis were followed up radiographically and clinically. For each method of osteosynthesis the initial nail position was correlated to the occurrence of late mechanical complica...
journal_title：Archives of orthopaedic and trauma surgery
pub_type： 杂志文章
doi：10.1007/BF00934155
更新日期：1989-01-01 00:00:00
abstract：INTRODUCTION:Even following the introduction of the "third generation" cementing technique, an improvement of the fixation of the acetabular component similar to that of the femoral has not been shown in clinical studies. The goal of the present study was to achieve a better stability with the use of an amphiphilic bon...
journal_title：Archives of orthopaedic and trauma surgery
pub_type： 杂志文章
doi：10.1007/s00402-007-0408-6
更新日期：2008-07-01 00:00:00
abstract：BACKGROUND:Potential adverse and unknown long-term effects as well as additional costs limit the use of BMPs (Bone morphogenetic proteins) in primary fusion procedures. However, the proven osteoinductive properties render BMPs attractive for the attempt to reach fusion of symptomatic non-unions. The aim of this study i...
journal_title：Archives of orthopaedic and trauma surgery
pub_type： 杂志文章
doi：10.1007/s00402-016-2485-x
更新日期：2016-08-01 00:00:00
abstract：PURPOSE:Polyethylene (PE) wear remains a common reason for revision surgery following total hip arthroplasty (THA). An established treatment method is isolated liner exchange in a well-fixed acetabular cup and entails a known high risk of hip dislocation after revision surgery. The purpose of this retrospective study w...
journal_title：Archives of orthopaedic and trauma surgery
pub_type： 杂志文章
doi：10.1007/s00402-020-03603-3
更新日期：2020-11-01 00:00:00
abstract：:We report a case of a sternal osteoid osteoma in a 39-year-old man. This localization is very rare and to our knowledge not described in literature. ...
journal_title：Archives of orthopaedic and trauma surgery
pub_type： 杂志文章
doi：10.1007/s00402-005-0071-8
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:Flexible flatfoot is a frequent deformity found in children. The aim of this study is to evaluate the pedographic outcome of the percutaneous arthroereisis with the use of a screw through the sinus tarsi into the talus. MATERIALS AND METHODS:43 calcaneo-stop procedures of 25 patients (18 bilateral, seven un...
journal_title：Archives of orthopaedic and trauma surgery
pub_type： 杂志文章
doi：10.1007/s00402-011-1316-3
更新日期：2011-10-01 00:00:00
abstract：:In revision total knee arthroplasty, osteotomy of the tibial tubercle provided satisfactory exposure to extract the broken tibial metal tray with rigidly fixed stem easily and safely. Three patients (three knees) underwent this osteotomy and were followed for a minimum of 2 years (range 2 years and 2 months to 2 years...
journal_title：Archives of orthopaedic and trauma surgery
pub_type： 杂志文章
doi：10.1007/BF00433999
更新日期：1997-01-01 00:00:00
abstract：INTRODUCTION:Bisphosphonate therapy has been associated with the development of atypical femoral fractures. The most common sites of bisphosphonate-associated fractures are at the subtrochanteric region followed by the femoral shaft. This retrospective study hypothesizes that increasing anterolateral femoral bow is ass...
journal_title：Archives of orthopaedic and trauma surgery
pub_type： 杂志文章
doi：10.1007/s00402-015-2297-4
更新日期：2015-11-01 00:00:00
abstract：:Permanent secondary stability of the uncemented femoral stem of hip prostheses can only be achieved once primary rotational and axial stability has been ensured. Rotational stability means that the stem is resistant to the articular forces that induce rotation around the implant's longitudinal axis. The 10-year surviv...
journal_title：Archives of orthopaedic and trauma surgery
pub_type： 杂志文章
doi：10.1007/s004020000215
更新日期：2001-01-01 00:00:00
abstract：BACKGROUND:With ankle arthritis often affecting young patients, joint-sparing treatments instead of total joint replacement should be considered. Only a few implants were specially developed for supramalleolar osteotomies (SMOT). This study was performed to analyse the stability of different implants and their appropri...
journal_title：Archives of orthopaedic and trauma surgery
pub_type： 杂志文章
doi：10.1007/s00402-018-2981-2
更新日期：2018-10-01 00:00:00
abstract：:Six patients with a displaced fracture of the neck or body of the talus were treated using biodegradable screws and rods. During an average follow-up time of 24 (range, 18-31) months, there were no redisplacements nor collapses due to avascular necrosis. All the fractures united. The functional result was mainly depen...
journal_title：Archives of orthopaedic and trauma surgery
pub_type： 杂志文章
doi：10.1007/BF00703443
更新日期：1998-01-01 00:00:00
abstract：:This study was designed to review the clinical experience of cementation in the treatment of giant cell tumor of bone and to clarify its biologic basis. Eleven patients treated by this technique had results rated excellent. No recurrences of the tumor were found. Serious complications, including infection, late fractu...
journal_title：Archives of orthopaedic and trauma surgery
pub_type： 杂志文章
doi：10.1007/BF00420253
更新日期：1993-01-01 00:00:00
abstract：INTRODUCTION:The aim of the study was to investigate the kinematics of the distal tibiofibular syndesmosis in intact and ligament injured ankles and to assess how effective is the syndesmotic screw in restraining mortise width variations during passive foot flexion. MATERIALS AND METHODS:The trials were carried out on...
journal_title：Archives of orthopaedic and trauma surgery
pub_type： 杂志文章
doi：10.1007/s00402-006-0131-8
更新日期：2006-07-01 00:00:00
abstract：INTRODUCTION:The purpose of this study is to analyze the mid-term outcomes of a modular monopolar type of radial head arthroplasty in the treatment of complex fractures associated with acute elbow joint instability. We postulated that radiographic changes are related to the development of clinical complications. MATER...
journal_title：Archives of orthopaedic and trauma surgery
pub_type： 杂志文章
doi：10.1007/s00402-019-03273-w
更新日期：2020-01-01 00:00:00
abstract：:Ankle fractures in the elderly are extremely common (up to 184 fractures per 100,000 persons per year, and of these approximately 20%-30% occur in the elderly). The medical literature contains no research that has investigated ankle fractures in the elderly. A prospective, randomised study was conducted of 84 patients...
journal_title：Archives of orthopaedic and trauma surgery
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s004020000172
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND:Total elbow arthroplasty is a relatively uncommon type of arthroplasty, which has undergone several design changes in the past four decades. However, research on improvement requires knowledge of failure mechanisms that can be addressed. Therefore, we conducted a systematic review on modes of failure of tota...
journal_title：Archives of orthopaedic and trauma surgery
pub_type： 杂志文章,评审
doi：10.1007/s00402-017-2687-x
更新日期：2017-06-01 00:00:00
abstract：INTRODUCTION/AIMS:Rotational alignment of the femoral prosthesis is important in total knee arthroplasty to improve performance and reduce complications. This study investigates the differences between two popular referencing methods and evaluates the variability of surgeons' techniques (inter-observer) and their repro...
journal_title：Archives of orthopaedic and trauma surgery
pub_type： 杂志文章
doi：10.1007/s00402-011-1273-x
更新日期：2011-09-01 00:00:00
abstract：INTRODUCTION:Troublesome heel spur is a nuisance condition that affects people of all ages. Treatment of patients with heel spur is a difficult and lengthy process requiring patience from both the patient and the therapist. Sometimes, the only and ultimate method of treatment is surgery, although spurs tend to recur. T...
journal_title：Archives of orthopaedic and trauma surgery
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00402-016-2503-z
更新日期：2016-09-01 00:00:00
