Peripheral blood steroid levels in Cushing syndrome due to adrenocortical carcinoma or adenoma.

Abstract:

:Measurement of the peripheral vein levels of the steroids in the adrenal biosynthetic pathway affords a further possible definitive method of differentiating adrenocortical carcinoma from adrenal adenoma in the presence of Cushing syndrome. In patients with adrenal carcinoma the blood levels of 17-hydroxyprogesterone, testosterone, androstenedione, and dehydroepiandrosterone are far higher than those seen in association with adenoma. In addition, the adrenal cortical carcinoma appears to have a higher ratio of precursors to product in the early part of the biosynthetic path and a lower one in the distal portion than adrenal adenomas. In Cushing syndrome due to adrenal tumor the measurement of serum cortisol is preferably made after chromatographic separation from 11-deoxycortisol in view of the marked cross reactivity in the protein binding procedure.

journal_name

Urology

journal_title

Urology

authors

Gabrilove JL,Freiberg EK,Nicolis GL

doi

10.1016/0090-4295(83)90298-4

subject

Has Abstract

pub_date

1983-12-01 00:00:00

pages

576-9

issue

6

eissn

0090-4295

issn

1527-9995

pii

0090-4295(83)90298-4

journal_volume

22

pub_type

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