Abstract:
OBJECTIVES:To determine the effect of milk and dairy intake on the development of all-cause dementia and its subtypes in an elderly Japanese population. DESIGN:Prospective cohort study. SETTING:The Hisayama Study, Japan. PARTICIPANTS:Individuals aged 60 and older without dementia (N = 1,081). MEASUREMENTS:Milk and dairy intake was estimated using a 70-item semiquantitative food frequency questionnaire grouped into quartiles. The risk estimates of milk and dairy intake on the development of all-cause dementia, Alzheimer's disease (AD), and vascular dementia (VaD) were computed using a Cox proportional hazards model. RESULTS:Over 17 years of follow-up, 303 subjects developed all-cause dementia; 166 had AD, and 98 had VaD. The age- and sex-adjusted incidence of all-cause dementia, AD, and VaD significantly decreased as milk and dairy intake level increased (P for trend = .03 for all-cause dementia, .04 for AD, .01 for VaD). After adjusting for potential confounders, the linear relationship between milk and dairy intake and development of AD remained significant (P for trend = .03), whereas the relationships with all-cause dementia and VaD were not significant. The risk of AD was significantly lower in the second, third, and fourth quartiles of milk and dairy intake than in the first quartile. CONCLUSION:Greater milk and dairy intake reduced the risk of dementia, especially AD, in the general Japanese population.
journal_name
J Am Geriatr Socjournal_title
Journal of the American Geriatrics Societyauthors
Ozawa M,Ohara T,Ninomiya T,Hata J,Yoshida D,Mukai N,Nagata M,Uchida K,Shirota T,Kitazono T,Kiyohara Ydoi
10.1111/jgs.12887subject
Has Abstractpub_date
2014-07-01 00:00:00pages
1224-30issue
7eissn
0002-8614issn
1532-5415journal_volume
62pub_type
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journal_title:Journal of the American Geriatrics Society
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2011-11-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
doi:10.1111/j.1532-5415.1990.tb03477.x
更新日期:1990-02-01 00:00:00
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journal_title:Journal of the American Geriatrics Society
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doi:10.1111/j.1532-5415.1997.tb03092.x
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更新日期:2000-03-01 00:00:00