Abstract:
:We undertook a prospective study to evaluate the effects of hemodialysis on serum prostate-specific antigen (PSA) in 26 male patients with end-stage renal disease as a clinical model for assessing the role of the kidney in PSA clearance. Patients ranging in age from fifty-one to eighty-three years (mean 64.8 years) underwent phlebotomy immediately before and after outpatient hemodialysis on a Monday/Wednesday/Friday or Tuesday/Thursday/Saturday schedule, with serum PSA values determined by the Abbott IMX Microparticle Enzyme Immunoassay. The mean +/- standard deviation for all post-dialysis PSA levels, 2.43 +/- 3.74, was significantly greater than that for pre-dialysis levels, 2.11 +/- 3.19 (p = 0.04). However, no statistically significant differences were found on comparing the combined pre- and post-dialysis PSA values over the course of the study (p = 0.2733) or when sequential pre-dialysis (p = 0.28) and post-dialysis (p = 0.92) levels were analyzed separately. We conclude that PSA is not eliminated by hemodialysis, and our results infer that it is not cleared by renal mechanisms.
journal_name
Urologyjournal_title
Urologyauthors
Monath JR,Burkart JM,Freedman BI,Pittaway DE,Russell GB,Assimos DGdoi
10.1016/0090-4295(93)90365-hsubject
Has Abstractpub_date
1993-10-01 00:00:00pages
398-400issue
4eissn
0090-4295issn
1527-9995pii
0090-4295(93)90365-Hjournal_volume
42pub_type
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