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Wireless blood pressure monitoring with a novel implantable device: long-term in vivo results.

Abstract：

PURPOSE:Devices constantly tracking the blood pressure (BP) of hypertensive patients are highly desired to facilitate effective patient management and to reduce hospitalization. We report on experiences gathered in a pilot study that was designed to evaluate the prototype of a newly developed, minimally invasive implantable sensor system for long-term BP monitoring. METHODS:The device was implanted in the femoral artery (FA) of 12 sheep via standard FA catheterization under fluoroscopic control. Accuracy of the recorded blood pressure was determined by comparison with a reference catheter, which was positioned in the contralateral FA immediately after implantation. Regular follow-up included angiography, computed tomography (CT), and control of functionality and position of the BP sensor. Animals were euthanized after 6 months. FA segments with in situ pressure sensor underwent macroscopic and histopathologic examinations. RESULTS:All implantations of the novel sensor device in the FA were successful and uneventful. High-quality BP recordings were documented. Bland-Altman plots indicate very good agreement. Comparison with measurements taken from the reference sensor revealed mean differences and standard deviations of -0.56 ± 0.85, 0.29 ± 1.44, and 0.85 ± 2.27 mmHg (diastolic, systolic, and pulse pressure, respectively) after exclusion of one outlier. CT uncovered deficiencies in cable stability that were addressed in a redesign. No thrombus formation, necrosis, or apoptosis were detected. CONCLUSIONS:The pilot study proved the technical feasibility of wireless BP measurement in the FA via a novel miniature sensor device.

journal_name

Cardiovasc Intervent Radiol

journal_title

Cardiovascular and interventional radiology

authors

Cleven NJ,Isfort P,Penzkofer T,Woitok A,Hermanns-Sachweh B,Steinseifer U,Schmitz-Rode T

doi

10.1007/s00270-014-0842-0

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

1580-8

issue

6

eissn

0174-1551

issn

1432-086X

journal_volume

37

pub_type

杂志文章

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