[A new thrombocyte aggregation-inhibiting and fibrinolysis-promoting synthetic molecule: RGDF (Arg-Gly-Asp-Phe) coupled with the carboxyterminal antiplasmin peptide].

Abstract:

OBJECTIVE:Synthesize such hybrid peptides, which contain the RGD (Arg-Gly-Asp) sequence coupled with another peptide containing lysine residues in special positions, to inhibit simultaneously platelet activation and promote fibrinolytic processes. DESIGN:The in vitro haemostasis modifying properties of the synthesized peptides were tested with ADP induced platelet aggregation, in vitro plasmin generation tests and fibrin-clot lysis assays. RESULTS AND CONCLUSIONS:RGDF (Arg-Gly-Asp-Phe) coupled with the carboxyterminal antiplasmin peptide (RGDFAP hybrid molecule) has a common concentration range for inhibiting platelet activation and increase plasmin generation along with accelerated in vitro fibrin-clot lysis.

journal_name

Orv Hetil

journal_title

Orvosi hetilap

authors

Udrardy M,Schwartzott D,Jackson K,McKee PA

subject

Has Abstract

pub_date

1995-01-15 00:00:00

pages

129-33

issue

3

eissn

0030-6002

issn

1788-6120

journal_volume

136

pub_type

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