Abstract:
OBJECTIVE:Synthesize such hybrid peptides, which contain the RGD (Arg-Gly-Asp) sequence coupled with another peptide containing lysine residues in special positions, to inhibit simultaneously platelet activation and promote fibrinolytic processes. DESIGN:The in vitro haemostasis modifying properties of the synthesized peptides were tested with ADP induced platelet aggregation, in vitro plasmin generation tests and fibrin-clot lysis assays. RESULTS AND CONCLUSIONS:RGDF (Arg-Gly-Asp-Phe) coupled with the carboxyterminal antiplasmin peptide (RGDFAP hybrid molecule) has a common concentration range for inhibiting platelet activation and increase plasmin generation along with accelerated in vitro fibrin-clot lysis.
journal_name
Orv Hetiljournal_title
Orvosi hetilapauthors
Udrardy M,Schwartzott D,Jackson K,McKee PAsubject
Has Abstractpub_date
1995-01-15 00:00:00pages
129-33issue
3eissn
0030-6002issn
1788-6120journal_volume
136pub_type
杂志文章,评审相关文献
ORVOSI HETILAP文献大全abstract::It is known that time-zone fatigue (jet lag syndrome) a transient physiological and mental condition occurs when people travel by jet between zones with time differences of five hours or longer. Jet lag syndrome is considered to develop because of internal desynchronization that results from a sudden difference betwee...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1994-08-07 00:00:00
abstract::The authors report a case of a 32-year-old patient who has been treated for idiopathic proctitis for 10 years. The inflammation did not react to Salazopyrin and corticosteroid therapy. Significant stenosis has developed. The probability of Chlamydia infection has emerged because of the atypical morphological appearanc...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1995-03-19 00:00:00
abstract::Endotoxin concentrations were measured in the portal, hepatic venous blood and abdominal aorta of six groups of rats in experimental alcoholic liver injury. Groups of animal consisted of 16 rats: I.: control group; II.: rats received one dose of E. coli 0127: B8-3 mg/kg intraperitoneally (i.p.), III.: rats received th...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1994-07-31 00:00:00
abstract:INTRODUCTION:Endoprosthetic replacement of the large joints is accompanied by major bleeding. During the last few years several authors reported the perioperative administration of tranexamic acid and its beneficial effect on reducing the blood loss. OBJECTIVES:In the present study, the author studied the effect of in...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/OH.2012.29455
更新日期:2012-10-14 00:00:00
abstract::Acute pancreatitis is one of the most common diseases of the gastrointestinal tract associated with significant morbidity and mortality that requires up-to-date and evidence based treatment guidelines. The Hungarian Pancreatic Study Group proposed to prepare evidence based guideline for the medical and surgical manage...
journal_title:Orvosi hetilap
pub_type: 杂志文章,实务指引,评审
doi:10.1556/OH.2015.30059
更新日期:2015-02-15 00:00:00
abstract::The detection of vasospasm plays an important role for the definition of the strategy of treatment in patients with subarachnoid hemorrhage (SAH). Besides the invasive contrast angiography, the non-invasive 99m-Tc-HMPAO brain perfusion SPECT and transcranial Doppler sonography (TCD) are recently used for this purpose....
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1996-08-18 00:00:00
abstract:UNLABELLED:The quality of endoscopic examinations substantially determines their value. In developed countries, Continuous Quality Management is used to improve it permanently. In Hungary there is no example for measuring quality in the field of gastrointestinal endoscopy. AIM:The measurement and improvement of qualit...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/OH.2012.29408
更新日期:2012-07-22 00:00:00
abstract::According to epidemiological studies, the prevalence of pituitary adenomas is 16.5% and the majority of them are "incidentalomas". The symptoms of pituitary disorders are often non-specific; disturbances of pituitary function, compression symptoms, hypophysis apoplexy or accidental findings may help the diagnosis. The...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:10.1556/OH.2009.28584
更新日期:2009-09-27 00:00:00
abstract::The results of 1122 laparoscopic cholecystectomies have been analyzed which were performed within a two year period of time. In 1097 (97.8%) cases the authors managed to carry out the laparoscopic procedure, however in 25 patients (2.2%) the operation had to be converted to an open surgery. There was no hospital morta...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:
更新日期:1994-07-24 00:00:00
abstract::Hemophagocytic lymphohistiocytosis is a multisystem inflammation, generated by the uncontrolled and excessive activation of cytotoxic T lymphocytes and natural killer cells. Severe immunodeficiency and generalized macrophage activation can often be detected in the background of this life threatening disorder. It is cl...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/OH.2014.29790
更新日期:2014-03-09 00:00:00
abstract:INTRODUCTION:In the 1984-1997 period 1179 tumorous patients presented themselves at the oesophagus consultation of the Ist. Department of Surgery of Semmelweis University. The authors examined the changes in the characteristic features of these patients and the task of supply. OBJECT:The aim of analysis was estimating...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:2004-02-08 00:00:00
abstract:INTRODUCTION:The occurrence of gram-positive infections caused by multiresistant organisms has increased significantly in general, particularly among the surgical patients, and only a few effective antibiotics are available. A new and effective, synthetic antibiotic, against gram-positives is the oxazolidinon group, th...
journal_title:Orvosi hetilap
pub_type: 临床试验,杂志文章,多中心研究
doi:
更新日期:2003-01-05 00:00:00
abstract:INTRODUCTION:Adult-onset acid maltase deficiency myopathy is a rare lysosomal storage disease with an autosomal recessive pattern of inheritance. The disease can be manifested with respiratory insufficiency and fatigue. METHODS:A case of a 45-year-old male patient is presented, and difficulty in diagnosis is discussed...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:2006-07-30 00:00:00
abstract::The last 20 years is one of the most remarkable periods in the fight against cancer, with the realization that some human papillomaviruses are causally related to cancer and with the development of the vaccine against human papillomavirus infections. This is a historical event in medicine and the prophylactic human pa...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/OH.2013.29593
更新日期:2013-04-21 00:00:00
abstract::Lycopene is a carotenoid found predominantly in tomatoes and tomato products. In contrast to beta-carotene it is not a precursor of vitamin A in humans. Lycopene is not destroyed during food processing, moreover its bioavailability improves. Lycopene is the most powerful antioxidant amongst carotenoids. Beside the ant...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:
更新日期:2005-07-31 00:00:00
abstract:INTRODUCTION:Although orbital compartment syndrome is a rare condition, it is still the most common cause of blindness following simple or complicated facial fractures. Its pathomechanism is similar to the compartment syndrome in the limb. Little extra fluid (blood, oedema, brain, foreign body) in a non-space yielding ...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/650.2017.30850
更新日期:2017-09-01 00:00:00
abstract::Progranulin is a recently recognized multifunctional glycopeptide shown to be related to obesity and diabetes mellitus. Progranulin is an endogenous antagonist of tumor necrosis factor-α by competitively binding to its receptor, therefore, it exerts anti-inflammatory activity. Paradoxically, previous studies have show...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:10.1556/650.2019.31356
更新日期:2019-06-01 00:00:00
abstract::The progression from panel doctor's system towards family medicine in Hungary is reviewed, including professional, educational, financial and legal background. The main barriers for further development are insufficient human resources, inadequate financial foundation, administrative overload and the present legal regu...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/OH.2009.28680
更新日期:2009-08-23 00:00:00
abstract::The authors performed 3539 successful endoscopic retrograde cholangio-panreatographies between 1982 and 1992. In 1160 (32.7%) of the cases was revealed some kind of pathological condition. In connection with one case, following conventional cholecystectomy, a very rare complication was diagnosed by endoscopic means. T...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1994-11-27 00:00:00
abstract::The effects of combined antibiotics (pefloxacin-doxycycline and pefloxacin-ceftriaxone) were tested on the most prevalent European Lyme spirochete species, Borrelia garinii by checkerboard dilution. The influence was judged both microscopically and by the measurement of the pH of the culture medium on the 5th day afte...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1999-07-04 00:00:00
abstract:UNLABELLED:Whipple's disease is a chronic, systemic, relapsing bacterial illness, which is always fatal without treatment, and means a diagnostic challenge for both clinicians and pathologists. It occurs in Caucasian, white, middle-aged men in 80 % of the cases. CASE REPORT:The authors present three cases, and review ...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/OH.2009.28668
更新日期:2009-07-12 00:00:00
abstract::Following the failure of conventional diagnostic procedures, whole-body FDG-PET investigations were carried out in 42 metastatic cancer patients to localize occult primary carcinomas. During the clinical follow-up, the presence of malignant tumor was ruled out in 3 cases, and 2 patients originally believed to have car...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:2002-05-26 00:00:00
abstract::The authors report about the elimination of foreign bodies fixed in the oesophagus and aspirated into the right main bronchus. They discuss the diagnostic work and the ways of its elimination. They emphasize the importance of cooperation between the endoscopist and the surgeon. ...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1992-07-12 00:00:00
abstract:INTRODUCTION:The phenomenon of stress induced left ventricular dysfunction has been long recognised. A special reversible form of it, characterized by left ventricular apical dilatation, is the so-called "tako-tsubo" or ampoule cardiomyopathy, based on its first description by Sato et al. in 1990. The tako-tsubo cardio...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/OH.2008.28181
更新日期:2008-02-24 00:00:00
abstract::The left ventricular stroke volume was determined in 15 healthy male volunteers of the same age (21-23 yrs). The systolic function was characterized by six, the diastolic function by five parameters. The diameter and the cross-sectional areas of the outflow tract were determined. Intraobserver, interobserver and day-t...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:
更新日期:1989-08-20 00:00:00
abstract:INTRODUCTION:Emotional, cognitive and behavioural aspects of birth and labour stress are strongly associated with the underlying physiological processes. AIM:To study the factors of physical security and social support, the administration of synthetic oxytocin, and how they relate to perceived stress during childbirth...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/650.2017.30797
更新日期:2017-07-01 00:00:00
abstract::Over recent years the clinical importance of invasive fungal infections has significantly increased. Mucormycosis refers to a rare, life threatening, opportunistic disease caused by filamentous fungi of the order Mucorales. Most frequently mucormycosis occurs in patients with ketoacidotic diabetes and in neutropenic p...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:2004-12-12 00:00:00
abstract::Results of epidemiological investigations were published only recently. The syndrome is particularly seldom diagnosed if the examination program is carried out not carefully enough in the case of patients, who have to be taken into consideration on the basis of different lesions. The syndrome differs from the majority...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:
更新日期:1996-06-02 00:00:00
abstract::Struma ovarii represents less than 3% of ovarian teratomas. It can be associated with thyroid biology abnormalities, and in exceptionally rare cases it can be malignant. The authors report a case of a 31-year-old woman who underwent resection of a left ovarian cyst, presenting with the clinical features of an ovarian ...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:10.1556/OH.2007.28202
更新日期:2007-12-02 00:00:00
abstract:INTRODUCTION:It shows the importance of cerebrovascular diseases that they are the third main cause of death exceeded only by coronary artery diseases and cancer. Cerebral ischemia leads to irreversible brain damage, thereby it is important to rescue the hypoperfused areas. Patients without stroke but with chronic cere...
journal_title:Orvosi hetilap
pub_type: 杂志文章,meta分析
doi:10.1556/OH.2007.28115
更新日期:2007-07-22 00:00:00