Abstract:
:We utilized a sample of 299 adult females aged between 19 and 86 years, carrying fragile X mental retardation (FMR1) alleles with small CCG expansions ranging from 50 to 141 repeats to analyse the relationships between psychological symptoms as assessed by the Symptom Checklist-90-Revised (SCL-90-R) and the size of the CGG repeat in the FMR1 gene. There were highly significant (negative) correlations between the size of the CGG repeat and a great majority of SCL-90-R subscale scores and all the global indices, suggesting that carriers of premutations in the mid-size CGG repeat range may be at greatest risk for the development of psychiatric disorder.
journal_name
Clin Genetjournal_title
Clinical geneticsauthors
Loesch DZ,Bui MQ,Hammersley E,Schneider A,Storey E,Stimpson P,Burgess T,Francis D,Slater H,Tassone F,Hagerman RJ,Hessl Ddoi
10.1111/cge.12347subject
Has Abstractpub_date
2015-02-01 00:00:00pages
173-8issue
2eissn
0009-9163issn
1399-0004journal_volume
87pub_type
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journal_title:Clinical genetics
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journal_title:Clinical genetics
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journal_title:Clinical genetics
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doi:10.1111/j.1399-0004.1984.tb01061.x
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journal_title:Clinical genetics
pub_type: 杂志文章
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