Serotonin receptors and their role in the pathophysiology and therapy of irritable bowel syndrome.

Abstract:

BACKGROUND:Irritable bowel syndrome (IBS) is a functional disorder of the gastrointestinal tract characterized by abdominal discomfort, pain and changes in bowel habits, often associated with psychological/psychiatric disorders. It has been suggested that the development of IBS may be related to the body's response to stress, which is one of the main factors that can modulate motility and visceral perception through the interaction between brain and gut (brain-gut axis). The present review will examine and discuss the role of serotonin (5-hydroxytryptamine, 5-HT) receptor subtypes in the pathophysiology and therapy of IBS. METHODS:Search of the literature published in English using the PubMed database. RESULTS:Several lines of evidence indicate that 5-HT and its receptor subtypes are likely to have a central role in the pathophysiology of IBS. 5-HT released from enterochromaffin cells regulates sensory, motor and secretory functions of the digestive system through the interaction with different receptor subtypes. It has been suggested that pain signals originate in intrinsic primary afferent neurons and are transmitted by extrinsic primary afferent neurons. Moreover, IBS is associated with abnormal activation of central stress circuits, which results in altered perception during visceral stimulation. CONCLUSIONS:Altered 5-HT signaling in the central nervous system and in the gut contributes to hypersensitivity in IBS. The therapeutic effects of 5-HT agonists/antagonists in IBS are likely to be due also to the ability to modulate visceral nociception in the central stress circuits. Further studies are needed in order to develop an optimal treatment.

journal_name

Tech Coloproctol

authors

Stasi C,Bellini M,Bassotti G,Blandizzi C,Milani S

doi

10.1007/s10151-013-1106-8

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

613-21

issue

7

eissn

1123-6337

issn

1128-045X

journal_volume

18

pub_type

杂志文章,评审
  • A new technique for sphincter-preserving anal fistula repair using a novel radial emitting laser probe.

    abstract::Anal fistula repair still remains challenging. Up to 30% of fistulas persist after surgery despite many improvements in surgical skills and technique. One major reason for surgical failure is a persistent fistula track or remnants of the fistula epithelium which could not be removed during surgery. To overcome this pr...

    journal_title:Techniques in coloproctology

    pub_type: 杂志文章

    doi:10.1007/s10151-011-0726-0

    authors: Wilhelm A

    更新日期:2011-12-01 00:00:00

  • Sigmoid intramural hematoma and hemoperitoneum: an early severe complication after stapled hemorrhoidopexy.

    abstract::Stapled hemorrhoidopexy is a widely used surgical technique for treating hemorrhoids, although severe complications have been reported. The authors report a rare case of extensive ascending intramural hematoma of the sigmoid colon complicating stapled hemorrhoidopexy, with perforation and hemoperitoneum. Diagnosis was...

    journal_title:Techniques in coloproctology

    pub_type: 杂志文章

    doi:10.1007/s10151-011-0696-2

    authors: De Santis G,Gola P,Lancione L,Sista F,Pietroletti R,Leardi S

    更新日期:2012-08-01 00:00:00

  • Right sided colorectal cancer increases with age and screening should be tailored to reflect this: a national cancer database study.

    abstract:BACKGROUND:In the United States, colorectal cancer (CRC) screening and surveillance is recommended until age 75. However, rates of surgery for CRC are greatest in the elderly, questioning current guidelines. Tumor sidedness is an emerging prognostic marker that may help guide screening and treatment decisions, with spe...

    journal_title:Techniques in coloproctology

    pub_type: 杂志文章

    doi:10.1007/s10151-020-02329-z

    authors: Reif de Paula T,Simon HL,Profeta da Luz MM,Keller DS

    更新日期:2020-08-27 00:00:00

  • Laparoscopic right colectomy: a systematic review and meta-analysis of observational studies comparing two types of anastomosis.

    abstract::Because of its technical difficulty, totally laparoscopic right colectomy with intracorporeal anastomosis is performed only by a small number of surgeons and most of them use a laparoscopic-assisted technique with extracorporeal anastomosis. This systematic review aims to evaluate differences in outcomes of patients u...

    journal_title:Techniques in coloproctology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s10151-013-1029-4

    authors: Carnuccio P,Jimeno J,Parés D

    更新日期:2014-01-01 00:00:00

  • Anal dilatation versus left lateral sphincterotomy for chronic anal fissure: a prospective randomized study.

    abstract::BACKGROUND: Several surgical methods are accepted for the treatment of chronic anal fissure. The most popular are anal dilatation (AD) and left lateral sphincterotomy (LLS). The objective of the current study was to prospectively evaluate the results of these two procedures in terms of recurrence rate, complications a...

    journal_title:Techniques in coloproctology

    pub_type: 杂志文章

    doi:10.1007/s10151-007-0373-7

    authors: Ram E,Vishne T,Lerner I,Dreznik Z

    更新日期:2007-12-03 00:00:00

  • Preoperative staging of perforated diverticulitis by computed tomography scanning.

    abstract:BACKGROUND:Treatment of perforated diverticulitis depends on disease severity classified according to Hinchey's preoperative classification. This study assessed the accuracy of preoperative staging of perforated diverticulitis by computerized tomography (CT) scanning. METHODS:All patients who presented with perforated...

    journal_title:Techniques in coloproctology

    pub_type: 杂志文章

    doi:10.1007/s10151-012-0853-2

    authors: Gielens MP,Mulder IM,van der Harst E,Gosselink MP,Kraal KJ,Teng HT,Lange JF,Vermeulen J

    更新日期:2012-10-01 00:00:00

  • Tips and tricks: haemorrhoidectomy with LigaSure.

    abstract::Haemorrhoidectomy is frequently associated with significant postoperative pain and prolonged hospital stay. New techniques to reduce these problems are constantly under evaluation. Amongst these, LigaSure haemorrhoidectomy is a safe and fast technique that fulfils the requirements of low-complication rate, fast wound ...

    journal_title:Techniques in coloproctology

    pub_type: 杂志文章

    doi:10.1007/s10151-009-0530-2

    authors: Milito G,Cadeddu F

    更新日期:2009-12-01 00:00:00

  • Importance of the Moskowitz artery in the laparoscopic medial approach to splenic flexure mobilization: a cadaveric study.

    abstract:BACKGROUND:The medial approach in laparoscopic splenic flexure mobilization is based on the entrance to the lesser sac just above the ventral edge of the pancreas (VEOP). The artery of Moskowitz runs through the base of the mesocolon, just above the VEOP. The aim of this study was to assess the incidence of the artery ...

    journal_title:Techniques in coloproctology

    pub_type: 杂志文章

    doi:10.1007/s10151-017-1663-3

    authors: Garcia-Granero A,Sánchez-Guillén L,Carreño O,Sancho Muriel J,Alvarez Sarrado E,Fletcher Sanfeliu D,Flor Lorente B,Frasson M,Martinez Soriano F,Garcia-Granero E

    更新日期:2017-07-01 00:00:00

  • Primary and repeated perineal stapled prolapse resection.

    abstract:BACKGROUND:Previous studies of the outcome after perineal stapled prolapse resection (PSPR) have included a limited number of patients with a short follow-up and high recurrence rates. The present study was designed to assess the initial results, complications, recurrence rate, and outcomes up to 4 years after PSPR, as...

    journal_title:Techniques in coloproctology

    pub_type: 杂志文章

    doi:10.1007/s10151-016-1557-9

    authors: Raahave D,Jensen AK,Dammegaard L,Pedersen IK

    更新日期:2016-12-01 00:00:00

  • Sacrococcygeal dimensions and curvature are associated with resection quality in rectal cancer excision.

    abstract:BACKGROUND:Technical factors affect oncologic outcomes in rectal cancer surgery. The anatomy of the bony pelvis can affect technical aspects of surgery, but is seldom considered preoperatively. We performed a morphometric analysis of the bony pelvis in patients having rectal cancer resection to assess its effect on sur...

    journal_title:Techniques in coloproctology

    pub_type: 杂志文章

    doi:10.1007/s10151-020-02273-y

    authors: Simpson G,Marks T,Blacker S,Smith D,Walsh C

    更新日期:2020-10-01 00:00:00

  • Trends in hospital admission for acute diverticulitis in Italy from 2008 to 2015.

    abstract:BACKGROUND:Epidemiological studies in Western countries have documented an increase of hospitalizations for acute diverticulitis (AD) but Italian evidence is scarce. The aim of the present study was to analyse the trend in hospitalization for AD, including in-hospital mortality, in Italy from 2008 to 2015. METHODS:Thr...

    journal_title:Techniques in coloproctology

    pub_type: 杂志文章

    doi:10.1007/s10151-018-1840-z

    authors: Binda GA,Mataloni F,Bruzzone M,Carabotti M,Cirocchi R,Nascimbeni R,Gambassi G,Amato A,Vettoretto N,Pinnarelli L,Cuomo R,Annibale B

    更新日期:2018-08-01 00:00:00

  • Chemoprevention of colorectal cancer: an update.

    abstract::Colorectal cancer (CRC) is the leading cause of cancer-related mortality in western countries. Adjuvant treatment does not seem to be highly effective and recurrent or metastatic disease occurs in half of the new cases within one year of diagnosis and median survival does not exceed 18 months. CRC represents an optima...

    journal_title:Techniques in coloproctology

    pub_type: 杂志文章,评审

    doi:10.1007/s10151-004-0170-5

    authors: Serrano D,Lazzeroni M,Decensi A

    更新日期:2004-12-01 00:00:00

  • Approach to the diagnosis and management of retained rectal foreign bodies: clinical update.

    abstract::Retained rectal foreign body is not an uncommon condition, but reliable epidemiological data are not available. The diagnosis and management can present a significant challenge due to delayed presentation and the reluctance of the patients to provide details of the incident. The aim of the clinical evaluation is to id...

    journal_title:Techniques in coloproctology

    pub_type: 杂志文章,评审

    doi:10.1007/s10151-012-0899-1

    authors: Ayantunde AA

    更新日期:2013-02-01 00:00:00

  • Poor outcome of sphincter repair: an evacuation problem?

    abstract:INTRODUCTION:Colorectal transport in idiopathic fecal incontinence has scarcely been studied, and it remains to be investigated in patients with fecal incontinence and anal sphincter lesion. The aim of the present study was to compare colorectal transport during defecation in patients with idiopathic fecal incontinence...

    journal_title:Techniques in coloproctology

    pub_type: 杂志文章

    doi:10.1007/s10151-010-0652-6

    authors: Michelsen HB,Christensen P,Buntzen S,Laurberg S,Krogh K

    更新日期:2011-03-01 00:00:00

  • Brachial plexus injury as a complication after colorectal surgery.

    abstract::Peripheral neuropathy associated with anesthesia is a significant source of morbidity and the second most frequent cause of professional liability in anesthetic practice. Nerve injuries are a well-recognised complication of anesthesia. Brachial plexus neuropathy is a rare syndrome with an incidence of 1.6 cases per 10...

    journal_title:Techniques in coloproctology

    pub_type: 杂志文章

    doi:10.1007/s10151-005-0212-7

    authors: Brill S,Walfisch S

    更新日期:2005-07-01 00:00:00

  • Fistulotomy or fistulectomy and primary sphincteroplasty for anal fistula (FIPS): a systematic review.

    abstract::There is still no clear consensus about surgical treatment of anal fistulas. Fistulotomy or fistulectomy and primary sphincter reconstruction is still regarded with skepticism. The aim of this systematic review was to evaluate the evidence in the literature supporting the use of this technique in the treatment of comp...

    journal_title:Techniques in coloproctology

    pub_type: 杂志文章,评审

    doi:10.1007/s10151-015-1323-4

    authors: Ratto C,Litta F,Donisi L,Parello A

    更新日期:2015-07-01 00:00:00

  • Long-term outcome of laparoscopic rectopexy for full-thickness rectal prolapse.

    abstract:BACKGROUND:The aim of this study was to assess the long-term outcomes of laparoscopic rectopexy for full-thickness rectal prolapse (FTRP). METHODS:Data of a prospectively maintained database were analysed. A structured telephone interview was conducted to assess a consecutive series of long-term outcomes of an unselec...

    journal_title:Techniques in coloproctology

    pub_type: 杂志文章

    doi:10.1007/s10151-018-1913-z

    authors: de Bruijn H,Maeda Y,Tan KN,Jenkins JT,Kennedy RH

    更新日期:2019-01-01 00:00:00

  • Confocal laser endomicroscopy in ulcerative colitis: beyond endoscopic assessment of disease activity.

    abstract:BACKGROUND:The aim of this study was to investigate the role of confocal laser endomicroscopy (CLE) in the assessment of disease activity in ulcerative colitis (UC). METHODS:Consecutive patients with UC referred to our inflammatory bowel disease unit for colonoscopy were enrolled. Patients without UC were used as cont...

    journal_title:Techniques in coloproctology

    pub_type: 杂志文章

    doi:10.1007/s10151-017-1654-4

    authors: Maione F,Giglio MC,Luglio G,Rispo A,D'Armiento M,Manzo B,Cassese G,Schettino P,Gennarelli N,Siciliano S,D'Armiento FP,De Palma GD

    更新日期:2017-07-01 00:00:00

  • Lymph road mapping obtained via blue sentinel node detection to avoid middle colic artery resection for highly selected colon cancer cases: proof of a concept?

    abstract:BACKGROUND:In theory, perioperative detection of lymph nodes with the injection of isosulfan blue dye should provide lymph road mapping (LRM) able to direct the resection. However, there is no supporting evidence for this theory in cases of colon cancer. We reanalysed all operative reports using the sentinel lymph node...

    journal_title:Techniques in coloproctology

    pub_type: 杂志文章

    doi:10.1007/s10151-010-0603-2

    authors: Lo Dico R,Lasser P,Goérè D,Malka D,Boige V,Pocard M

    更新日期:2010-09-01 00:00:00

  • Screening for colorectal cancer using a quantitative immunochemical faecal occult blood test: a feasibility study in an Asian population.

    abstract:BACKGROUND:The quantitative immunochemical faecal occult blood test (qFOBT) has been shown to be an accurate method of identifying significant colorectal neoplasia including cancer and advanced adenomas. This study reports the results of a Singapore population-based colorectal cancer screening event using the qFOBT. M...

    journal_title:Techniques in coloproctology

    pub_type: 杂志文章

    doi:10.1007/s10151-009-0515-1

    authors: Fu WP,Kam MH,Ling WM,Ong SF,Suzannah N,Eu KW

    更新日期:2009-09-01 00:00:00

  • A novel device reduces anal pain after rubber band ligation: a randomized controlled trial.

    abstract:BACKGROUND:Anal pain is a well-known sequel of rubber band ligation (RBL). A plastic device, the anal cooler which can be frozen in a freezer, has been developed to reduce anal pain. It contains a mixture of glycols and has a minimum temperature of 4 °C. This study was designed to investigate the efficacy of the anal c...

    journal_title:Techniques in coloproctology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s10151-012-0824-7

    authors: Lam TJ,Felt-Bersma RJ

    更新日期:2012-06-01 00:00:00

  • A modified anoscope to facilitate the purse-string suture for stapled hemorrhoidopexy.

    abstract::Stapled hemorrhoidopexy is an alternative method to conventional surgical procedures for third-degree hemorrhoids. It has many advantages such as less pain, faster recovery and earlier return to work. Nevertheless, many reports mentioned the persistence of postoperative pain, hemorrhage, recurrence, sphincter injury, ...

    journal_title:Techniques in coloproctology

    pub_type: 杂志文章

    doi:10.1007/s10151-005-0236-z

    authors: Bozdağ AD

    更新日期:2005-12-01 00:00:00

  • The utilization of intraluminal formalin for intractable rectal haemorrhage in advanced rectal cancer: a case report.

    abstract::A patient with a metastatic fixed low rectal carcinoma presented severe rectal bleeding requiring massive transfusion over with a 36-hour period. Bleeding was controlled with the instillation of a 4% intrarectal formalin solution permitting the completion of a course of neoadjuvant chemoradiotherapy. This technique ha...

    journal_title:Techniques in coloproctology

    pub_type: 杂志文章

    doi:10.1007/s10151-005-0193-6

    authors: Zbar AP,Bernstein S,Greaves N,Iniss M,Shenoy RK

    更新日期:2005-04-01 00:00:00

  • Extralevator versus standard abdominoperineal excision for rectal cancer.

    abstract:BACKGROUND:Extralevator abdominoperineal excision (ELAPE) probably improves the oncological quality of low rectal cancer surgery, as compared to standard abdominoperineal excision (SAPE), possibly due to lower rates of accidental perioperative bowel perforations and lower rates of circumferential resection margin (CRM)...

    journal_title:Techniques in coloproctology

    pub_type: 杂志文章

    doi:10.1007/s10151-014-1243-8

    authors: Perdawood SK,Lund T

    更新日期:2015-03-01 00:00:00

  • Robotic versus laparoscopic surgery for rectal cancer: a comparative cost-effectiveness study.

    abstract:BACKGROUND:The differences between the costs of robotic rectal resection and of the laparoscopic approach are still not well known. The aim of this study was to evaluate the cost-effectiveness of robotic versus laparoscopic surgery. METHODS:We conducted an observational, comparative, prospective, non-randomized study ...

    journal_title:Techniques in coloproctology

    pub_type: 杂志文章

    doi:10.1007/s10151-020-02151-7

    authors: Quijano Y,Nuñez-Alfonsel J,Ielpo B,Ferri V,Caruso R,Durán H,Díaz E,Malavé L,Fabra I,Pinna E,Isernia R,Hidalgo Á,Vicente E

    更新日期:2020-03-01 00:00:00

  • The use of an acellular porcine dermal collagen implant in the repair of complex abdominal wall defects: a European multicentre retrospective study.

    abstract:BACKGROUND:The use of biological materials for the repair of complex abdominal wall defects has increased over the years; however, the role of these materials in routine practice remains unclear. The aim of the study was to evaluate clinical outcomes following the use of Permacol™ porcine collagen surgical implant in c...

    journal_title:Techniques in coloproctology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s10151-015-1307-4

    authors: Giordano P,Pullan RD,Ystgaard B,Gossetti F,Bradburn M,McKinley AJ,Smart NJ,Daniels IR

    更新日期:2015-07-01 00:00:00

  • Accuracy of endorectal ultrasonography in the preoperative staging of rectal cancer.

    abstract:BACKGROUND:Preoperative staging of rectal tumours is considered essential to tailoring treatment for individual patients. The aim of the present study was to evaluate the accuracy of 3-D-endorectal ultrasonography for the preoperative staging of rectal cancer. METHODS:Three hundred and fifty-seven patients with rectal...

    journal_title:Techniques in coloproctology

    pub_type: 杂志文章

    doi:10.1007/s10151-004-0099-8

    authors: Manger T,Stroh C

    更新日期:2004-11-01 00:00:00

  • Colonic motility studies in severe chronic constipation: an organic approach to a functional problem.

    abstract::Chronic constipation is one of the more frequent functional gastrointestinal symptoms. The more severe cases not infrequently undergo a major surgical approach. However, there is still a need for a better diagnostic and therapeutic approach, since the results are still unpredictable, probably due to a poor selection o...

    journal_title:Techniques in coloproctology

    pub_type: 杂志文章,评审

    doi:10.1007/s10151-004-0078-0

    authors: Bassotti G,de Roberto G,Sediari L,Morelli A

    更新日期:2004-11-01 00:00:00

  • Ultrasonographic evaluation of anal endometriosis: report of four cases.

    abstract:BACKGROUND:The presence of endometriosis in the anal canal and perianal tissues is rare and difficult to suspect at clinical examination. We report our experience with preoperative ultrasound evaluation of four cases of anal endometriosis. METHODS:Four patients were evaluated by transperineal and high-resolution three...

    journal_title:Techniques in coloproctology

    pub_type: 杂志文章

    doi:10.1007/s10151-014-1176-2

    authors: Kołodziejczak M,Sudoł-Szopińska I,Santoro GA,Bielecki K,Wiączek A

    更新日期:2014-11-01 00:00:00

  • The management of rectal cancer with synchronous liver metastases: a modern surgical dilemma.

    abstract:INTRODUCTION:One in ten patients with rectal cancer presents with synchronous colorectal liver metastases. We present an up-to-date review of the different surgical strategies available for rectal cancer patients with synchronous colorectal liver metastases. METHOD:A literature review of MEDLINE, Cochrane and Google s...

    journal_title:Techniques in coloproctology

    pub_type: 杂志文章,评审

    doi:10.1007/s10151-012-0888-4

    authors: Slesser AA,Bhangu A,Brown G,Mudan S,Tekkis PP

    更新日期:2013-02-01 00:00:00