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Presentational approaches used in the UK for reporting evidence synthesis using indirect and mixed treatment comparisons.

Abstract：

OBJECTIVES:To establish current guidance and practice in UK on presentation of indirect comparison and mixed treatment comparison analyses; to provide recommendations to improve indirect comparison/mixed treatment comparison reporting and to identify research priorities for improved presentation. METHODS:Existing institutional guidance for conducting indirect comparison/mixed treatment comparison alongside current practice in health technology assessment was reviewed. Reports published in UK by the Health Technology Assessment programme since 1997, which utilized indirect comparison/mixed treatment comparison methods, were reviewed with respect to the presentation of study data, statistical models and results. Recommendations for presentation were developed. RESULTS:Guidance exists that provide the details necessary to conduct a successful indirect comparison/mixed treatment comparison analysis but recommendations on presentation are limited. Of 205 health technology assessment reports that contained evidence synthesis for effectiveness, 19 used indirect comparison/mixed treatment comparison methods. These reports utilized numerous presentational formats from which the following key components were identified: network table/diagram for presenting data; model description to allow reproducibility; and tables, forest plots, matrix tables and summary forest plots for presenting a range of results. Recommendations were developed to ensure that reporting is explicit, transparent and reproducible. Approaches most understandable by non-technical decision makers, and areas where future research is required, are outlined. CONCLUSIONS:There is no standard presentational style used in UK for reporting indirect comparison/mixed treatment comparison, and the use of graphical tools is limited. Standardization of reporting and innovation in graphical representation of indirect comparison/mixed treatment comparison results is required.

journal_name

J Health Serv Res Policy

journal_title

Journal of health services research & policy

authors

Tan SH,Bujkiewicz S,Sutton A,Dequen P,Cooper N

doi

10.1177/1355819613498379

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

224-32

issue

eissn

1355-8196

issn

1758-1060

pii

1355819613498379

journal_volume

pub_type

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Presentational approaches used in the UK for reporting evidence synthesis using indirect and mixed treatment comparisons.