Analysis of breast cancer pedigrees using affected sibship methods.

Abstract:

:Haplotype-sharing was examined in sets of affected siblings in the Breast Cancer Linkage Consortium pedigrees [Easton et al., 1993], using both identity-by-descent and identity-by-state methods. Linkage of the disease susceptibility locus to markers on chromosome 17 was confirmed. Substantial genetic heterogeneity was found, with more young cases being attributable to the putative gene. No differences were found between breast and ovarian cancer, and there was no evidence against a simple dominant mode of inheritance.

journal_name

Genet Epidemiol

journal_title

Genetic epidemiology

authors

Barrett JH,Rigby AS

doi

10.1002/gepi.1370120653

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

847-51

issue

6

eissn

0741-0395

issn

1098-2272

journal_volume

12

pub_type

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