Abstract：
:The authors compared detection methods for cell proliferation in human anterior pituitary adenomas using histological sections and dispersed cell culture. After tumor cells had been grown for 4 days in dispersed culture, bromodeoxyuridine (BUdR), proliferating cell nuclear antigen (PCNA), and Ki-67 were compared by double immunostaining and contrasted with single staining of PCNA and Ki-67 indices in the corresponding histological sections from 12 human pituitary adenomas. In vitro, the BUdR labeling index was positive in six of 12 tumors (range < 0.1-5.1%), 10 of 12 tumors were PCNA-positive (range < 0.1-100%), and Ki-67 was positive in 10 of 12 adenomas (range < 0.1-8%). In vitro, BUdR and Ki-67 gave similar proliferative indices for 10 of 12 adenomas. In vivo, the PCNA labeling index was positive in 12 of 12 adenomas (range 0.9-95%) and Ki-67 was positive in 11 of 12 adenomas (range < 0.1-2%). Tumors with a labeling index less than 0.1% were considered to be negative for proliferation. High PCNA values were found in vitro and in vivo, whereas Ki-67 labeling indices were similar in vitro and in vivo for nine of 12 adenomas. It is concluded that Ki-67 proliferative indices in vivo reflect those found in vitro, at least after 4 days in dispersed culture, but that PCNA overestimates pituitary adenoma proliferation in histological sections as well as in dispersed culture.
journal_name
J Neurosurgjournal_title
Journal of neurosurgeryauthors
Atkin SL,Green VL,Hipkin LJ,Landolt AM,Foy PM,Jeffreys RV,White MCdoi
10.3171/jns.1997.87.1.0085subject
Has Abstractpub_date
1997-07-01 00:00:00pages
85-8issue
1eissn
0022-3085issn
1933-0693journal_volume
87pub_type
杂志文章abstract：:Space-occupying lesions of the basal ganglia are a rare cause of extrapyramidal dysfunction in children. Metastatic pineal germinoma in both basal ganglia produced dystonia in a 12-year-old boy. The literature is reviewed. Extrapyramidal manifestations in the child are compared with previously reported cases of basal ...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/jns.1978.48.1.0108
更新日期：1978-01-01 00:00:00
abstract：:Computerized tomography (CT) scans of 54 patients with an arteriovenous malformation (AVM) of the brain were reviewed. The 31 males and 23 females (mean age: 33 years) were classified according to clinical presentation: 1) intracranial hemorrhage (30 patients); 2) seizure disorder (19 patients); and 3) other neurologi...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/jns.1979.51.6.0765
更新日期：1979-12-01 00:00:00
abstract：:The mortality rate has recently been reduced to only a small percentage of patients selected for early aneurysm surgery. Despite recovery without neurological deficits, however, a diffuse encephalopathy may remain, with emotional and psychological sequelae that will interfere with rehabilitation and social reintegrati...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/jns.1985.62.5.0673
更新日期：1985-05-01 00:00:00
abstract：:A patient with a subcutaneous sacrococcygeal ependymoma and metastasis to the inguinal lymph nodes is presented and his treatment is described. Previous reports on sacrococcygeal ependymoma are reviewed. ...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/jns.1988.68.3.0474
更新日期：1988-03-01 00:00:00
abstract：:OBJECTIVE Although reoperation and readmission have been used as quality metrics, there are limited data evaluating the rate of, reasons for, and predictors of reoperation and readmission after microsurgical clipping of unruptured aneurysms. METHODS Adult patients who underwent craniotomy for clipping of an unruptured...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/2016.10.JNS161810
更新日期：2018-03-01 00:00:00
abstract：:A new technique is presented in which expandable compressed Ivalon sponge emboli were used to obliterate an intramedullary arteriovenous malformation of the spinal cord by intraparenchymal embolization. A case is described in which this method was used. ...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/jns.1977.47.1.0119
更新日期：1977-07-01 00:00:00
abstract：OBJECT:Nuclear receptor corepressor (N-CoR) forms a complex that maintains neural stem cells in an undifferentiated state through transcriptional repression. Recently, it has been shown that N-CoR is overexpressed in glioblastoma multiforme (GBM) tumor stem cells and has a putative role in maintaining these cells in an...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/2009.11.JNS091272
更新日期：2010-08-01 00:00:00
abstract：:Language impairments were reviewed retrospectively in patients who underwent partial or total corpus callosum section for medically refractory secondary generalized epilepsy. Postoperatively, four of 32 patients had clinically significant language impairments that were not present prior to the operation. All involved ...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/jns.1990.72.1.0085
更新日期：1990-01-01 00:00:00
abstract：:A 9-week-old infant manifested continuous vomiting for 1 week accompanied by a tense fontanel, "sun setting" of the eyes, frequent opisthotonos, and hypertonicity. The head circumference was at the 50th percentile. Computerized tomography (CT) revealed acute hydrocephalus and a posterior fossa subdural hematoma. The b...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/jns.1977.47.6.0949
更新日期：1977-12-01 00:00:00
abstract：:The authors present the case of an intraneural ganglion cyst of the peroneal nerve. The cyst was diagnosed by means of ultrasound, which also gave an exact definition of its size and location, confirmed at operation. Some controversial aspects of these lesions are discussed. ...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/jns.1992.76.3.0538
更新日期：1992-03-01 00:00:00
abstract：:OBJECTIVE Hemangiopericytomas (HPCs) are rare tumors widely recognized for their aggressive clinical behavior, high recurrence rates, and distant and extracranial metastases even after a gross-total resection. The authors report a large multicenter study, through the International Gamma Knife Research Foundation (IGKR...
journal_title：Journal of neurosurgery
pub_type： 杂志文章,多中心研究
doi：10.3171/2016.1.JNS152860
更新日期：2017-03-01 00:00:00
abstract：OBJECT:Acute subdural hematomas (SDHs) impart serious morbidity and mortality on the elderly population, with only 5% of those older than 65 years of age attaining functional independence. Despite its widespread use, oral antithrombotic therapy (OAT) in the context of acute SDH has not been extensively studied. The aut...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/2010.7.JNS10446
更新日期：2011-01-01 00:00:00
abstract：:Neural foundations underlying visual agnosia are poorly understood. The authors present the case of a patient who underwent awake surgery for a right basal temporooccipital low-grade glioma in which direct electrostimulation was used both at the cortical and subcortical level. Brain mapping over the inferior longitudi...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/2012.10.JNS12527
更新日期：2013-01-01 00:00:00
abstract：:Precise intraoperative localization of retained bone fragments and foreign bodies avoids extensive brain disseciton, cerebral edema, damage to vital structures, incomplete debridement, and prolonged surgical procedures. Such localization after head trauma is often hampered by cerebral distortion, previous incomplete d...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/jns.1977.46.1.0065
更新日期：1977-01-01 00:00:00
abstract：OBJECTIVE:Iatrogenic nerve injuries are devastating to both the patient and the surgeon. This study focuses on the anatomical relationship of the palmar recurrent branch with the parent median nerve in an attempt to identify higher risk types. METHODS:The palmar recurrent branch was dissected in 75 embalmed cadavers. ...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/2019.4.JNS19516
更新日期：2019-07-05 00:00:00
abstract：OBJECT:The use of nicardipine prolonged-release implants (NPRIs) is associated with a significant improvement in the therapy of patients suffering from aneurysmal subarachnoid hemorrhage (aSAH) regarding the occurrence and severity of cerebral vasospasm, new infarcts, and functional outcome (FO). Because quality of lif...
journal_title：Journal of neurosurgery
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.3171/2008.2.17670
更新日期：2009-05-01 00:00:00
abstract：:Secure fixation of the sacrum is technically challenging. The bone of the dorsal sacral surface is often thin, making hook fixation tenuous. The use of bone screws in the sacral pedicles has gained popularity, but rigidity is often not achieved and screw pullout is common. Solid constructs have been achieved using ang...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/jns.1994.81.2.0313
更新日期：1994-08-01 00:00:00
abstract：OBJECT:This study was performed to provide quantitative data on the number of surviving facial motor neurons that extend regenerated nerve fibers through the nerve-injured site and to reveal the relationship between facial function and the number of those motor neurons in which the facial nerve has been transected or r...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/ped.2005.102.4.0390
更新日期：2005-05-01 00:00:00
abstract：OBJECT:This investigation was performed to determine the tolerance and toxicities of split-course fractionated gamma knife radiosurgery (FSRS) given in combination with conventional external-beam radiation therapy (CEBRT). METHODS:Eighteen patients with previously unirradiated, gliomas treated between March 1995 and J...
journal_title：Journal of neurosurgery
pub_type： 临床试验,杂志文章
doi：10.3171/jns.2000.93.supplement
更新日期：2000-12-01 00:00:00
abstract：:The incidence of extracranial internal carotid artery (ICA) abnormalities, namely kinks, coils, and stenoses, was evaluated in a consecutive unselected series of 76 cases of single supratentorial saccular aneurysms submitted to bilateral carotid angiography. These patients were compared with a control group of 120 pat...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/jns.1981.55.5.0693
更新日期：1981-11-01 00:00:00
abstract：:Gas myelography was carried out in 22 patients with acute cervical spinal cord injuries in whom oily contrast media seemed contraindicated. The authors believe this technique makes a valuable contribution to the basic decision regarding the surgical versus medical treatment of a specific patient with a cervical cord i...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/jns.1975.42.3.0330
更新日期：1975-03-01 00:00:00
abstract：:The International Cooperative Study on the Timing of Aneurysm Surgery evaluated the results of surgical and medical management in 3521 patients between December, 1980, and July, 1983. At admission, 75% of patients were in good neurological condition and surgery was performed in 83%. At the 6-month evaluation, 26% of t...
journal_title：Journal of neurosurgery
pub_type： 临床试验,杂志文章,多中心研究
doi：10.3171/jns.1990.73.1.0018
更新日期：1990-07-01 00:00:00
abstract：OBJECT:The aims of this study were to construct an animal model of deafferentation of the spinal cord by brachial plexus avulsion and to analyze the effects of subsequent dorsal root entry zone (DREZ) lesions in this model. To this end, the authors measured the clinical and electrophysiological effects of total deaffer...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/jns.2002.97.6.1402
更新日期：2002-12-01 00:00:00
abstract：OBJECT:The authors analyzed the effects of socioeconomic status (SES) and geographic variations on survival rates for adults and children with glioma, studying the data of 30,489 adults and 2940 children from the Cancer Registry in England and Wales. METHODS:The median survival time and crude survival rates for eight ...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/ped.2006.105.4.297
更新日期：2006-10-01 00:00:00
abstract：:Corticosteroids are frequently used in the treatment of spinal trauma, although neither experimental nor clinical evidence to support their use is persuasive. Recently there have been claims that extremely high doses ("megadoses") of corticosteroids (equivalent to 15 to 30 mg/kg of methylprednisolone) improve neurolog...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/jns.1984.60.4.0712
更新日期：1984-04-01 00:00:00
abstract：:Intracranial pressure (ICP) was continuously recorded, isotope cisternography was performed, and the ventricular system size was evaluated on serial computerized tomography scans in 39 patients. All of these patients had communicating hydrocephalus after subarachnoid hemorrhage (SAH) from rupture of an intracranial an...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/jns.1985.62.2.0220
更新日期：1985-02-01 00:00:00
abstract：:The authors demonstrate the use of cottonoid as a marker for ultrasound localization of a subcortical tumor. ...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/jns.1984.60.2.0438
更新日期：1984-02-01 00:00:00
abstract：OBJECT:Medically refractory dystonia has recently been treated using deep brain stimulation (DBS) targeting the globus pallidus internus (GPI). Outcomes have varied depending on the features of the dystonia. There has been limited literature regarding outcomes for refractory dystonia following DBS of the subthalamic nu...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/JNS-07/07/0029
更新日期：2007-07-01 00:00:00
abstract：:An unusual case of a sacral, extradural choroid plexus papilloma involving the S1-3 level is described. This 50-year-old woman presented with a 4-month history of pain involving her right buttock, perineum, and leg. Contrast-enhanced magnetic resonance (MR) imaging of the spine revealed a well-defined, mildly enhancin...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/spi.2002.97.1.0102
更新日期：2002-07-01 00:00:00
abstract：OBJECTIVE:Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is known to reduce motor symptoms of Parkinson's disease (PD). The effects of DBS on various nonmotor symptoms often differ from patient to patient. The factors that determine whether or not a patient will respond to treatment have not been elucida...
journal_title：Journal of neurosurgery
pub_type： 杂志文章
doi：10.3171/2020.6.JNS201126
更新日期：2020-10-09 00:00:00
