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The key to the allergenicity of lipid transfer protein (LTP) ligands: A structural characterization.

Abstract：

:Plant lipid transfer proteins are a large family that can be found in all land plants. They have a hydrophobic cavity that allows them to harbor lipids and facilitates their traffic between membranes. However, in humans, this plant protein family is responsible for the main food allergies in the Mediterranean area. Nevertheless, not only the protein itself but also its ligand is relevant for allergic sensitization. The main aim of the present work is to analyse the natural ligands carried by four allergenic LTPs (Tri a 14, Art v 3, Par j 2, and Ole e 7), compared with the previously identified ligand of Pru p 3 (CPT-PHS ligand), and clarify their role within the immunological reactions. Results showed that the ligands of the LTPs studied shared a chemical identity, in which the presence of a polar head was essential to the protein-ligand binding. This ligand was transported through a skin cellular model, and phosphorylated phytosphingosine could be detected as result of cell metabolism. Since sphingosine kinase 1 was overexpressed in keratinocytes incubated with the LTP-ligand complex, this enzyme might be responsible for the phosphorylation of the phytosphingosine fraction of the CPT-PHS ligand. This way, phytosphingosine-1-phosphate could be mimicking the role of the human inflammatory mediator sphingosine-1-phosphate, explaining why LTPs are associated with more severe allergic responses. In conclusion, this work contributes to the understanding of the chemical nature and behavior of lipid ligands carried by allergens, which would help to gain insight into their role during allergic sensitization.

journal_name

Biochim Biophys Acta Mol Cell Biol Lipids

journal_title

Biochimica et biophysica acta. Molecular and cell biology of lipids

authors

Gonzalez-Klein Z,Cuevas-Zuviria B,Wangorsch A,Hernandez-Ramirez G,Pazos-Castro D,Oeo-Santos C,Romero-Sahagun A,Pacios LF,Tome-Amat J,Scheurer S,Diaz-Perales A,Garrido-Arandia M

doi

10.1016/j.bbalip.2021.158928

keywords:

["Food allergy","Ligand","Lipid transfer protein","Phytosphingosine"]

subject

Has Abstract

pub_date

2021-07-01 00:00:00

pages

158928

issue

7

eissn

1388-1981

issn

1879-2618

pii

S1388-1981(21)00054-8

journal_volume

1866

pub_type

杂志文章

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