Abstract:
:Physical exercise leads to beneficial effects in numerous tissues and organ systems and offers protection against obesity and type 2 diabetes. Recent studies have investigated the role of exercise on brown adipose tissue (BAT) and white adipose tissue (WAT), and have indicated marked adaptations to each tissue with exercise. Studies investigating the effects of exercise on BAT have produced conflicting results, with some showing an increase in the thermogenic activity of BAT and some demonstrating a decrease in the thermogenic activity of BAT. Human studies have observed a down-regulation of BAT activity (measured by a reduction in glucose uptake) in response to exercise. In WAT, exercise decreases adipocyte size, alters gene expression, and increases mitochondrial activity. Transplantation of exercise-trained subcutaneous WAT (scWAT) improves whole-body metabolic health. In rodents, exercise also results in a beiging of scWAT. Thus, exercise-induced changes to adipose tissue may be part of the mechanism by which exercise improves metabolic health.
journal_name
Biochim Biophys Acta Mol Cell Biol Lipidsauthors
Dewal RS,Stanford KIdoi
10.1016/j.bbalip.2018.04.013keywords:
["BAT","Beige adipose tissue","Exercise","Metabolism"]subject
Has Abstractpub_date
2019-01-01 00:00:00pages
71-78issue
1eissn
1388-1981issn
1879-2618pii
S1388-1981(18)30075-1journal_volume
1864pub_type
杂志文章,评审相关文献
文献大全abstract::Autophagy is an evolutionarily conserved mechanism that maintains nutrient homeostasis by degrading protein aggregates and damaged organelles. Autophagy is reduced in aging, which is implicated in the pathogenesis of aging-related diseases, including cancers, obesity, type 2 diabetes, cardiovascular diseases, and neur...
journal_title:Biochimica et biophysica acta. Molecular and cell biology of lipids
pub_type: 杂志文章,评审
doi:10.1016/j.bbalip.2016.08.003
更新日期:2017-01-01 00:00:00
abstract::Sphingolipids are bioactive lipids found in cell membranes that exert a critical role in signal transduction. In recent years, it has become apparent that sphingolipids participate in growth, senescence, differentiation and apoptosis. The anabolism and catabolism of sphingolipids occur in discrete subcellular location...
journal_title:Biochimica et biophysica acta. Molecular and cell biology of lipids
pub_type: 杂志文章,评审
doi:10.1016/j.bbalip.2016.09.019
更新日期:2017-01-01 00:00:00
abstract::Mass spectrometry of lipids, especially those isolated from bacteria, has ballooned over the past two decades, affirming in the process the complexity of the lipidome. With this has come the identification of new and interesting lipid structures. Here is an overview of several novel lipids, from both Gram-negative and...
journal_title:Biochimica et biophysica acta. Molecular and cell biology of lipids
pub_type: 杂志文章,评审
doi:10.1016/j.bbalip.2016.10.003
更新日期:2017-11-01 00:00:00
abstract:RATIONALE:Cholesteryl hemiesters are oxidation products of polyunsaturated fatty acid esters of cholesterol. Their oxo-ester precursors have been identified as important components of the "core aldehydes" of human atheromata and in oxidized lipoproteins (Ox-LDL). We had previously shown, for the first time, that a sing...
journal_title:Biochimica et biophysica acta. Molecular and cell biology of lipids
pub_type: 杂志文章
doi:10.1016/j.bbalip.2016.10.009
更新日期:2017-02-01 00:00:00
abstract::The Raetz pathway of lipid A biosynthesis plays a vital role in the survival and fitness of Gram-negative bacteria. Research efforts in the past three decades have identified individual enzymes of the pathway and have provided a mechanistic understanding of the action and regulation of these enzymes at the molecular l...
journal_title:Biochimica et biophysica acta. Molecular and cell biology of lipids
pub_type: 杂志文章,评审
doi:10.1016/j.bbalip.2016.11.014
更新日期:2017-11-01 00:00:00
abstract::Lysophospholipids (LPLs) are metabolic intermediates in bacterial phospholipid turnover. Distinct from their diacyl counterparts, these inverted cone-shaped molecules share physical characteristics of detergents, enabling modification of local membrane properties such as curvature. The functions of LPLs as cellular gr...
journal_title:Biochimica et biophysica acta. Molecular and cell biology of lipids
pub_type: 杂志文章,评审
doi:10.1016/j.bbalip.2016.11.015
更新日期:2017-11-01 00:00:00
abstract::Small heterodimer partner (SHP) is an atypical nuclear receptor expressed in heart that has been shown to inhibit the hypertrophic response. Here, we assessed the role of SHP in cardiac metabolism and inflammation. Mice fed a high-fat diet (HFD) displayed glucose intolerance accompanied by increased cardiac mRNA level...
journal_title:Biochimica et biophysica acta. Molecular and cell biology of lipids
pub_type: 杂志文章
doi:10.1016/j.bbalip.2017.02.006
更新日期:2017-05-01 00:00:00
abstract::Over the last two decades, lipidomics has evolved into an 'omics' technology pari passu with benchmarking 'omics' technologies, such as genomics or proteomics. The driving force behind this development was a constant advance in mass spectrometry and related technologies. The aim of this opinion article is to give the ...
journal_title:Biochimica et biophysica acta. Molecular and cell biology of lipids
pub_type: 杂志文章,评审
doi:10.1016/j.bbalip.2017.03.004
更新日期:2017-08-01 00:00:00
abstract::The cDNA encoding human gastric lipase (HGL) was integrated into the genome of Pichia pastoris using the pGAPZα A transfer vector. The HGL signal peptide was replaced by the yeast α-factor to achieve an efficient secretion. Active rHGL was produced by the transformed yeast but its levels and stability were dependent o...
journal_title:Biochimica et biophysica acta. Molecular and cell biology of lipids
pub_type: 杂志文章
doi:10.1016/j.bbalip.2017.07.002
更新日期:2017-10-01 00:00:00
abstract::Three proteins have been implicated in the assembly of cytoplasmic lipid droplets: seipin, FIT2, and perilipin. This review examines the current theories of seipin function as well as the evidence for the involvement of all three proteins in droplet biogenesis, and ends with a proposal of how they collaborate to regul...
journal_title:Biochimica et biophysica acta. Molecular and cell biology of lipids
pub_type: 杂志文章,评审
doi:10.1016/j.bbalip.2017.07.003
更新日期:2017-10-01 00:00:00
abstract::Carriers of an epsilon 4 allele (E4) of apolipoprotein E (APOE) develop Alzheimer's disease (AD) earlier than carriers of other APOE alleles. The metabolism of plasma docosahexaenoic acid (DHA, 22:6n-3), an omega-3 fatty acid (n-3 FA), taken up by the brain and concentrated in neurons, is disrupted in E4 carriers, res...
journal_title:Biochimica et biophysica acta. Molecular and cell biology of lipids
pub_type: 杂志文章,评审
doi:10.1016/j.bbalip.2017.07.004
更新日期:2017-10-01 00:00:00
abstract::Statins have been proven to be effective in treating non-alcoholic fatty liver disease (NAFLD). Recently, it was reported that statins decreased the hepatic expression of perilipin 5 (Plin5), a lipid droplet (LD)-associated protein, which plays critical roles in regulating lipid accumulation and lipolysis in liver. Ho...
journal_title:Biochimica et biophysica acta. Molecular and cell biology of lipids
pub_type: 杂志文章
doi:10.1016/j.bbalip.2017.09.007
更新日期:2017-12-01 00:00:00
abstract::Yarrowia lipolytica is considered as a promising microbial cell factory for bio-oil production due to its ability to accumulate a large amount of lipid. However, the regulation of lipid metabolism in this oleaginous yeast is elusive. In this study, the MHY1 gene was disrupted, and 43.1% (w/w) intracellular oil based o...
journal_title:Biochimica et biophysica acta. Molecular and cell biology of lipids
pub_type: 杂志文章
doi:10.1016/j.bbalip.2017.10.003
更新日期:2018-01-01 00:00:00
abstract::Hydrogen sulfide (H2S) has been recognized as an important gasotransmitter analogous to nitric oxide and carbon monoxide. Cystathionine gamma-lyase (CSE)-derived H2S is implicated in the regulation of insulin resistance and glucose metabolism, but the involvement of CSE/H2S system in energy homeostasis and fat mass ha...
journal_title:Biochimica et biophysica acta. Molecular and cell biology of lipids
pub_type: 杂志文章
doi:10.1016/j.bbalip.2017.11.008
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:The multi-step bile acid 7α-dehydroxylating pathway by which a few species of Clostridium convert host primary bile acids to toxic secondary bile acids is of great importance to gut microbiome structure and host physiology and disease. While genes in the oxidative arm of the 7α-dehydroxylating pathway have b...
journal_title:Biochimica et biophysica acta. Molecular and cell biology of lipids
pub_type: 杂志文章
doi:10.1016/j.bbalip.2017.12.001
更新日期:2018-03-01 00:00:00
abstract::Phosphoinositides are present in the plasma membrane, cytoplasm and inside the cell nucleus. Here we identify phosphatidylinositol-4,5-bisphosphate (PIP2) as a regulator of rRNA genes transcription at the epigenetic level. We show that PIP2 directly interacts with histone lysine demethylase PHF8 (PHD finger protein 8)...
journal_title:Biochimica et biophysica acta. Molecular and cell biology of lipids
pub_type: 杂志文章
doi:10.1016/j.bbalip.2017.12.008
更新日期:2018-03-01 00:00:00
abstract::The thermogenic activities of brown and beige adipocytes can be exploited to reduce energy surplus and counteract obesity. Recent RNA sequencing studies have uncovered a number of long noncoding RNAs (lncRNAs) uniquely expressed in white and brown adipose tissues (WAT and BAT), but whether and how these lncRNAs functi...
journal_title:Biochimica et biophysica acta. Molecular and cell biology of lipids
pub_type: 杂志文章
doi:10.1016/j.bbalip.2018.01.008
更新日期:2018-04-01 00:00:00
abstract::Macrophages in adipose tissue contribute to inflammation and the development of insulin resistance in obesity. Exposure of macrophages to saturated fatty acids alters cell metabolism and activates pro-inflammatory signaling. How fatty acids influence macrophage mitochondrial dynamics is unclear. We investigated the me...
journal_title:Biochimica et biophysica acta. Molecular and cell biology of lipids
pub_type: 杂志文章
doi:10.1016/j.bbalip.2018.01.009
更新日期:2018-04-01 00:00:00
abstract::Phosphatidylglycerol (PG) is an indispensable lipid class in photosynthetic activity. However, the importance of PG biosynthesis in non-photosynthetic organs remains elusive. We previously identified phosphatidylglycerophosphate phosphatase 1 (PGPP1), which catalyzes the last step of PG biosynthesis in Arabidopsis tha...
journal_title:Biochimica et biophysica acta. Molecular and cell biology of lipids
pub_type: 杂志文章
doi:10.1016/j.bbalip.2018.02.007
更新日期:2018-06-01 00:00:00
abstract:AIMS:Fatty acid binding protein 4 (FABP4) inhibitors have been proposed as potential therapeutic approaches against insulin resistance-related inflammation and type 2 diabetes mellitus. However, the underlying molecular mechanisms by which these molecules drive these effects in skeletal muscle remain unknown. Here, we ...
journal_title:Biochimica et biophysica acta. Molecular and cell biology of lipids
pub_type: 杂志文章
doi:10.1016/j.bbalip.2018.03.004
更新日期:2018-06-01 00:00:00
abstract::Brown adipose tissue (BAT) dissipates energy as heat and its activity correlates with leanness in human adults. Understanding the mechanisms behind the activation of BAT and the process of "browning", i.e. the appearance of inducible brown adipocytes called beige or brite (brown-in-white) cells in white adipose tissue...
journal_title:Biochimica et biophysica acta. Molecular and cell biology of lipids
pub_type: 杂志文章,评审
doi:10.1016/j.bbalip.2018.05.003
更新日期:2019-01-01 00:00:00
abstract::Proprotein convertase subtilisin/kexin 9 (PCSK9), a protein regulating the number of cell-surface LDL receptors (LDLR), circulates partially associated to plasma lipoproteins. How this interaction alters PCSK9 plasma levels is still unclear. In the present study, we took advantage of the availability of a large cohort...
journal_title:Biochimica et biophysica acta. Molecular and cell biology of lipids
pub_type: 杂志文章
doi:10.1016/j.bbalip.2018.05.015
更新日期:2018-09-01 00:00:00
abstract::Glutathione peroxidases (GPX) are anti-oxidative enzymes that reduce organic and inorganic hydroperoxides to the corresponding alcohols at the expense of reduced glutathione. The human genome involves eight GPX genes and five of them encode for selenocysteine-containing enzymes. Among the human GPX-isoforms, GPX4 is u...
journal_title:Biochimica et biophysica acta. Molecular and cell biology of lipids
pub_type: 杂志文章
doi:10.1016/j.bbalip.2018.06.006
更新日期:2018-09-01 00:00:00
abstract::Hyperosmolarity is a controversial signal for renal cells. It can induce cell stress or differentiation and both require an active lipid metabolism. We showed that hyperosmolarity upregulates phospholipid (PL) de novo synthesis in renal cells. PL synthesis requires fatty acids (FA), usually stored as triglycerides (TA...
journal_title:Biochimica et biophysica acta. Molecular and cell biology of lipids
pub_type: 杂志文章
doi:10.1016/j.bbalip.2018.06.012
更新日期:2018-09-01 00:00:00
abstract::Prostaglandin E2 (PGE2) is responsible for inflammatory symptoms. However, PGE2 also suppresses pro-inflammatory cytokine production. There are at least 4 subtypes of PGE2 receptors, EP1-EP4, but it is unclear which of these specifically control cytokine production. The aim of this study was to determine which of the ...
journal_title:Biochimica et biophysica acta. Molecular and cell biology of lipids
pub_type: 杂志文章
doi:10.1016/j.bbalip.2018.07.003
更新日期:2018-10-01 00:00:00
abstract::Resistance against chemotherapy is a life-threatening complication in colon cancer therapy. To increase response rate, new additional targets that contribute to chemoresistance are still needed to be explored. Ceramides, which belong to the group of sphingolipids, are well-known regulators of cell death and survival, ...
journal_title:Biochimica et biophysica acta. Molecular and cell biology of lipids
pub_type: 杂志文章
doi:10.1016/j.bbalip.2018.07.011
更新日期:2018-10-01 00:00:00
abstract::In microalgae, triacylglycerol (TAG) biosynthesis occurs by parallel pathways involving both the chloroplast and endoplasmic reticulum. A better understanding of contribution of each pathway to TAG assembly facilitates enhanced TAG production via rational genetic engineering of microalgae. Here, using a UPLC-MS(/MS) c...
journal_title:Biochimica et biophysica acta. Molecular and cell biology of lipids
pub_type: 杂志文章
doi:10.1016/j.bbalip.2018.09.009
更新日期:2018-12-01 00:00:00
abstract::SND1 is a putative oncoprotein whose molecular function remains unclear. Its overexpression in hepatocellular carcinoma impairs cholesterol homeostasis due to the altered activation of the sterol regulatory element-binding protein (SREBP) 2, which results in the accumulation of cellular cholesteryl esters (CE). In thi...
journal_title:Biochimica et biophysica acta. Molecular and cell biology of lipids
pub_type: 杂志文章
doi:10.1016/j.bbalip.2018.11.004
更新日期:2019-02-01 00:00:00
abstract::Lipid homeostasis is important for executing normal cellular functions and maintaining physiological conditions. The biophysical properties and intricate metabolic network of lipids underlie the coordinated regulation of different lipid species in lipid homeostasis. To reveal the homeostatic response among different l...
journal_title:Biochimica et biophysica acta. Molecular and cell biology of lipids
pub_type: 杂志文章
doi:10.1016/j.bbalip.2018.11.010
更新日期:2019-02-01 00:00:00
abstract::Key homeostatic functions are regulated in a diurnal manner and a miss-alignment of such rhythms is believed to contribute to the pathophysiology of several diseases. Signaling sphingolipids (SLs) in plasma such as sphingosine 1-phosphate control lymphocytic trafficking, vascular reactivity and platelet activity, phys...
journal_title:Biochimica et biophysica acta. Molecular and cell biology of lipids
pub_type: 杂志文章
doi:10.1016/j.bbalip.2018.12.001
更新日期:2019-03-01 00:00:00