Effect of dopamine receptor antagonists on cocaine subjective effects: a naturalistic case study.

Abstract:

:Schizophrenic patients on neuroleptic medications abuse cocaine and report cocaine-induced euphoria. This study was undertaken to provide better clinical characterization of these phenomena by administering the POMS and a custom-designed questionnaire. A group of heavy cocaine users who were not mentally ill served as the control group. The results clearly suggest that schizophrenic patients report cocaine-induced euphoria and post-use craving despite being treated with therapeutic doses of haloperidol or fluphenazine. The responses of the control group were similar to that of the schizophrenic group except that the latter subjects reported a greater degree of anxiety. These results suggest that blockade of D2 receptors is not sufficient to block cocaine-induced subjective effects in humans.

journal_name

J Subst Abuse Treat

authors

Ohuoha DC,Maxwell JA,Thomson LE 3rd,Cadet JL,Rothman RB

doi

10.1016/s0740-5472(96)00161-4

subject

Has Abstract

pub_date

1997-05-01 00:00:00

pages

249-58

issue

3

eissn

0740-5472

issn

1873-6483

pii

S0740547296001614

journal_volume

14

pub_type

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