Abstract：
STUDY DESIGN:Laboratory investigation in rats submitted to experimental spinal cord injury (SCI). OBJECTIVE:To characterize changes in renal function during acute SCI. METHODS:Sprague Dawley rats were subjected to severe spinal cord contusion at T8 level or to laminectomy as control. Twenty-four hours after spine surgery, clearance assessments of a single dose of iohexol (120 mg kg(-1)) or of p-aminohippuric acid (PAH, 100 mg kg(-1)) were used to evaluate glomerular filtration rate (GFR) and tubular secretion (TS), respectively. Blood sampling was used to determine concentrations of both compounds by high-performance liquid chromatography for pharmacokinetic measurements. RESULTS:Iohexol clearance decreased significantly after injury, which resulted in increased concentrations and half-life of iohexol in blood; PAH clearance remained unchanged. CONCLUSION:GFR but not TS is altered during spinal shock. These observations should be of interest to professionals caring for early cord-injured patients, in order to prevent toxicity and therapeutic failure when administering drugs eliminated by the kidney.
journal_name
Spinal Cordjournal_title
Spinal cordauthors
Rodríguez-Romero V,Cruz-Antonio L,Franco-Bourland RE,Guízar-Sahagún G,Castañeda-Hernández Gdoi
10.1038/sc.2013.35subject
Has Abstractpub_date
2013-07-01 00:00:00pages
528-31issue
7eissn
1362-4393issn
1476-5624pii
sc201335journal_volume
51pub_type
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