Effect of ketorolac tromethamine (Toradol) on ischemia-reperfusion injury in skeletal muscle.

Abstract:

:The eicosanoids, leukotriene B4 (LTB4) and thromboxane A2 (TXA2), contribute to neutrophil adhesion and arteriole vasoconstriction, important microcirculatory events in ischemia-reperfusion (I-R) injury. The purpose of this study was to evaluate the effect of ketorolac on I-R injury of skeletal muscle. A videomicroscopic preparation of gracilis muscle in male Wistar rats (n=7) in two experimental groups was evaluated: Group 1-4 hr global ischemia only (19 arterioles, 19 venules), and Group 2-4 hr ischemia plus ketorolac (13 arterioles, 14 venules). Ketorolac (0.86 mg/kg, i.m.) was given 30 min prior to reperfusion. The number of neutrophils, rolling and adherent, was counted in 100-micron venular segments, and arteriole diameters were measured at 5, 15, 30, 60 and 120 min of reperfusion. The I-R-induced increase in neutrophil adhesion was significantly reduced by ketorolac, which significantly increased arteriolar vasodilation in the first 30 min of reperfusion and significantly reduced the I-R-induced vasoconstriction in arterioles at 30 min; this effect was lost at 1 hr of reperfusion. Although ketorolac augments immediate arteriole vasodilation and blocks subsequent vasoconstriction, this effect appears to be transient. These findings suggest that ketorolac may have potential as a treatment for I-R injury.

journal_name

J Reconstr Microsurg

authors

Yao KA,Roth AC,Stephenson LL,Suchy H,Zamboni WA

doi

10.1055/s-2007-1000170

subject

Has Abstract

pub_date

1998-04-01 00:00:00

pages

211-4

issue

3

eissn

0743-684X

issn

1098-8947

journal_volume

14

pub_type

杂志文章
  • Closure of big toe defects after wrap-around flap transfer using the arterialized venous flap.

    abstract::Sixteen arterialized venous flaps, free flaps that have arterial blood only flowing through the vein of the flap, were applied to reconstruct skin defects of the big toe resulting from wrap-around flap transfers. There were seven complete successes, six partial successes, and three complete failures. The clinical cour...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2007-1006756

    authors: Inoue G,Maeda N,Suzuki K

    更新日期:1991-01-01 00:00:00

  • Outcomes of Muscle Reinnervation with Direct Nerve Implantation into the Native Motor Zone of the Target Muscle.

    abstract::Background Our recent work has demonstrated that the native motor zone (NMZ) within a given skeletal muscle is the best site for muscle reinnervation. This study was designed to explore the outcomes of direct nerve implantation (DNI) into the NMZ of denervated sternomastoid (SM) muscle in a rat model. Methods The righ...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-0036-1592362

    authors: Sobotka S,Chen J,Nyirenda T,Mu L

    更新日期:2017-02-01 00:00:00

  • Special Considerations for Diabetic Foot Reconstruction.

    abstract::Successful reconstruction of diabetic ulcers using free flap surgery can prevent further amputation and promote limb salvage to maintain normal gait of the patient and increase the quality of life after surgery. To minimize the postoperative complication and days of stay in hospital, surgeons should thoroughly investi...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-0040-1714431

    authors: Suh HP,Park CJ,Hong JP

    更新日期:2021-01-01 00:00:00

  • Microsurgical reconstruction of the hepatic and superior mesenteric arteries using a back wall technique.

    abstract::During the last seven years, 17 patients underwent microsurgical reconstruction of 14 hepatic and four superior mesenteric arterial systems following extended pancreatectomy or hepatectomy, and in living-related liver transplantations (LRLT). All microvascular anastomoses in this series were performed using a back wal...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2007-1000109

    authors: Yamamoto Y,Sugihara T,Sasaki S,Furukawa H,Furukawa H,Okushiba S,Nohira K

    更新日期:1999-07-01 00:00:00

  • The profunda femoris artery "fourth perforator" island flap: a new perforator flap in lower-limb reconstruction.

    abstract::Although the lateral thigh flap has been well described as a fasciocutaneous flap based on one or more of the four perforators of the profunda femoris artery, the role for these individual perforators as perforator flaps has not been described. These profunda femoris artery perforators offer a particularly useful opti...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-0031-1275494

    authors: Rozen WM,Donahoe S,Wilson JL

    更新日期:2011-05-01 00:00:00

  • The ultra-thin, fascia-only anterolateral thigh flap.

    abstract:BACKGROUND:While many potential donor sites have been described for fascial (fascia-only) flaps, a fascial flap harvested from the anterolateral thigh (ALT) donor site has not gained popularity, likely because of concerns regarding inadequate perfusion of the deep fascia. However, recent clinical experience demonstrate...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-0033-1361843

    authors: Bhadkamkar MA,Wolfswinkel EM,Hatef DA,Albright SB,Echo A,Hsu PW,Izaddoost SA

    更新日期:2014-11-01 00:00:00

  • Does Postoperative Anticoagulation Therapy Lead to a Higher Success Rate for Microvascular Free-Tissue Transfer in the Head and Neck? A Systematic Review and Meta-Analysis.

    abstract:BACKGROUND: Due to limited evidence, it is unclear whether postoperative anticoagulation therapy may lead to higher success rates for microvascular free-flap surgery in the head and neck. This review evaluated whether postoperative anticoagulation therapy can lead to a better result in head and neck reconstruction. ME...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章,meta分析,评审

    doi:10.1055/s-0037-1606346

    authors: Liu J,Shi Q,Yang S,Liu B,Guo B,Xu J

    更新日期:2018-02-01 00:00:00

  • Posterior radial collateral artery as the basis of the lateral forearm flap.

    abstract::The lateral forearm flap is being increasingly used for covering minor-to-moderate-sized defects for which soft and thin skin is required. Within the framework of an anatomic study carried out on 28 cadaveric arms, the authors investigated the principal artery that supplies blood to this flap namely, the posterior rad...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2000-7537

    authors: Meirer R,Schrank C,Putz R

    更新日期:2000-01-01 00:00:00

  • Outcomes of Subfascial, Suprafascial, and Super-Thin Anterolateral Thigh Flaps: Tailoring Thickness without Added Morbidity.

    abstract:BACKGROUND: Subfascial anterolateral thigh (ALT) flap thickness can be problematic with regards to bulk, oral competence, shoe-fit, or as a potential source of recurrent wound breakdown. We have utilized distinct upper thigh fascial planes to fashion thin (suprafascial) or super-thin (periscarpal) ALT flaps to improve ...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-0037-1607426

    authors: Diamond S,Seth AK,Chattha AS,Iorio ML

    更新日期:2018-03-01 00:00:00

  • The relationship of functional return to varying methods of nerve repair.

    abstract::This experimental study correlated varying methods of nerve repair with the degree of functional return using the rat sciatic nerve as a model. Six groups of adult male Sprague-Dawley rats (300 to 350 g) had their left sciatic nerve crushed (Group 1), transected and not repaired (Group 6), or transected and repaired u...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2007-1006804

    authors: Buehler MJ,Seaber AV,Urbaniak JR

    更新日期:1990-01-01 00:00:00

  • Donor-site morbidity of the sensate extended lateral arm flap.

    abstract::The free extended lateral arm flap (ELAF) has gained increasing popularity thank to its slimness and versatility, longer neurovascular pedicle, and greater flap size when compared with the original flap design. The aim of this study was to assess the donor-site morbidity associated with this extended procedure. A retr...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-0031-1289165

    authors: Depner C,Erba P,Rieger UM,Iten F,Schaefer DJ,Haug M

    更新日期:2012-02-01 00:00:00

  • Superficial ulnar artery: embryology, case report, and clinical significance in reconstructive microsurgery.

    abstract::In this paper the authors describe and illustrate a rare anatomic variation of the ulnar artery, a superficial ulnar artery. The possible embryologic events responsible for this variation are discussed. In addition, they describe the surgical considerations that should be kept in mind when this abnormality is encounte...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2007-1000120

    authors: Yuksel M,Yuksel E,Weinfeld AB,Shenaq SM

    更新日期:1999-08-01 00:00:00

  • Preclinical efficacy of slow-release bFGF in ischemia-reperfusion injury in a Dorsal Island skin flap model.

    abstract::The effect of slow-release basic fibroblast growth factor (bFGF) on ischemia-reperfusion injury was examined using an island skin flap model in rats. Paired rectangular island skin flaps were elevated on the dorsum of 30 Fischer rats. The flaps were subjected to 6 hours of ischemia. Before reperfusion the flaps were i...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-0033-1343830

    authors: Wang Y,Orbay H,Huang C,Tobita M,Hyakusoku H,Myamoto M,Tabata Y,Mizuno H

    更新日期:2013-06-01 00:00:00

  • The combined gracilis and semitendinosus free flap in the rat.

    abstract::A free-flap model in rats is presented, that consists of gracilis and semitendinosus muscles pedicled on the femoral vessels, in continuation with deep femoral and saphenous vessels. This flap was transferred to the contralateral side in 40 rats and yielded a 95 percent survival rate. The weight of the flaps averaged ...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2007-1000175

    authors: Ionac M,Geishauser M

    更新日期:1998-05-01 00:00:00

  • Reverse Dorsoradial Flaps for Thumb Coverage Show Increased Sensory Recovery with Smaller Flap Sizes.

    abstract:BACKGROUND:Reverse homodigital dorsoradial (RHD) flap has been developed to repair soft-tissue defects of the thumb. However, few articles have reported this flap with long-term follow-up. This retrospective study was designed to evaluate the RHD flap and investigate factors affecting sensory recovery. METHODS:From Fe...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-0035-1548743

    authors: Sun YC,Chen QZ,Chen J,Gong YP,Gu JH

    更新日期:2015-07-01 00:00:00

  • Blood flow and microcirculatory changes in an ischemia-reperfusion injury model: experimental study in the rabbit.

    abstract::This is the first in a series of studies designed to investigate the simultaneous changes in blood flow and microcirculation in an island flap during ischemia, in an ischemia-reperfusion model in the rabbit. An island groin flap based on the inferior epigastric vessels was harvested in 17 rabbits. The flap was rendere...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2007-1006414

    authors: Gürlek A,Schusterman MA,Evans GR,Gherardini G

    更新日期:1997-07-01 00:00:00

  • Intraoperative decision making by electrophysiological detection of the origin of thoracodorsal nerve in the C7 nerve root transfer procedure.

    abstract::The objective of this article is to discuss the significance of predicting the injury degree of the thoracodorsal nerve by intraoperative electrophysiological examination in the C7 nerve root transfer for brachial plexus injury. Each trunk of the brachial plexus followed by each bundle of C7 was stimulated before the ...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-0030-1263291

    authors: Lu W,Xu J,Wang D

    更新日期:2011-01-01 00:00:00

  • Facial nerve reconstruction using a vascularized lateral femoral cutaneous nerve graft based on the superficial circumflex iliac artery system: an application of the inferolateral extension of the groin flap.

    abstract::The use of an inferolateral extension technique of a groin flap has previously been reported. This technique involves harvesting an extended portion from the anterolateral thigh, including the lateral femoral cutaneous nerve (LFCN) and its accompanying vessels, attached to a groin flap via communications between the L...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-0030-1263288

    authors: Kashiwa K,Kobayashi S,Nasu W,Kuroda T,Higuchi H

    更新日期:2010-11-01 00:00:00

  • Topical Vasodilators in Microsurgery: What Is the Evidence?

    abstract::Background Topical vasodilators are frequently used during free tissue transfer to prevent and treat vasospasm and microvascular thrombosis. A variety of agents have been studied and are available, yet most microsurgeons select an agent based on anecdotal evidence or personal training. Our aim was to review the litera...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章,评审

    doi:10.1055/s-0036-1592191

    authors: Rinkinen J,Halvorson EG

    更新日期:2017-01-01 00:00:00

  • Hand Perfusion in Patients with Physiological or Pathological Allen's Tests.

    abstract:BACKGROUND: The Allen test (AT) is a widely used clinical tool for the preoperative assessment of sufficient dual vessel hand perfusion although the impact of a pathological AT on tissue perfusion of the hand is not entirely clear. This study reveals perfusion changes of the hand in patients with pathological and physi...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-0038-1668159

    authors: Bartella AK,Flick N,Kamal M,Steegmann J,Kloss-Brandstätter A,Teichmann J,Hölzle F,Lethaus B

    更新日期:2019-03-01 00:00:00

  • Patient Safety in Microvascular Plastic Surgery.

    abstract::Patient safety is defined as freedom from accidental or preventable harm produced by medical care. The identification of patient- and procedure-related risk factors enables the surgical team to carry out prophylactic measures to reduce the rate of complications and adverse events.The purpose of this review is to ident...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章,评审

    doi:10.1055/s-0039-1693142

    authors: Colakoglu S,Tebockhorst S,Chong TW,Mathes DW

    更新日期:2019-11-01 00:00:00

  • Distal Nerve Transfer: Perspective of Reconstructive Microsurgery.

    abstract::Recent articles have strongly emphasized the superiority of distal nerve transfers despite indefinite assessment. I would like to introduce the problems associated with functional evaluation following nerve transfers. ...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章,评审

    doi:10.1055/s-0038-1639369

    authors: Doi K

    更新日期:2018-11-01 00:00:00

  • Donor operation for face transplantation.

    abstract::The first clinical face allotransplantation was performed by Devauchelle et al in 2005, and currently 13 facial allotransplantations have been performed worldwide. Reports on almost half of the cases were published in the literature, focusing on technical details of facial allograft inset to the recipient face. There ...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章,评审

    doi:10.1055/s-0031-1272963

    authors: Siemionow M,Ozturk C

    更新日期:2012-01-01 00:00:00

  • Vascular endothelial growth factor gene therapy in improvement of skin paddle survival in a rat TRAM flap model.

    abstract::The use of growth factors in inducing angiogenesis and enhancing flap viability has provided promising results. Targeted gene therapy has evolved in hopes of increasing the longevity and effectiveness of these growth factor treatments. The purpose of this study was to examine the effect of preoperative treatment by va...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2005-915207

    authors: Zhang F,Yang F,Hu EC,Sones W,Lei M,Lineaweaver WC

    更新日期:2005-08-01 00:00:00

  • The emerging role of the direct cutaneous muscle perforator found arising from the muscle vessel hilum.

    abstract::Perforator flaps based on either musculocutaneous or septocutaneous perforators are no longer a curiosity, but rather in the past decade have become "workhorse" soft tissue alternatives. Yet a keener understanding of their anatomy abetted by sophisticated imaging techniques has revealed other deep fascia perforators w...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章,评审

    doi:10.1055/s-0032-1315777

    authors: Hallock GG

    更新日期:2012-10-01 00:00:00

  • Simultaneous soft-tissue reconstruction and revascularization of the thumb with a flow-through distally-pedicled radial forearm flap.

    abstract::The authors report the application of the flow-through concept to a distally-pedicled radial forearm flap for simultaneous thumb revascularization and soft-tissue coverage. A distally-pedicled radial forearm flap was used to cover a skin defect at the base of thumb and thenar area. The flap artery (reversed radial art...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2007-1000206

    authors: Karacalar A,Idil O,Ozcan M

    更新日期:1998-10-01 00:00:00

  • Direct muscle neurotization in rat soleus muscle.

    abstract::An experimental study was conducted using rat soleus muscles to characterize reinnervation of the denervated muscles by direct muscle neurotization. Also studied was whether there is any difference in the regeneration process between original (tibial) and foreign (peroneal) nerve neurotization. For functional evaluati...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2000-7349

    authors: Park DM,Shon SK,Kim YJ

    更新日期:2000-07-01 00:00:00

  • Chest wall reconstruction with a free extended forearm flap. A case report.

    abstract::Forequarter amputation combined with chest wall resection may present a difficult closure problem. In a recent case, the defect was satisfactorily closed with a free flap from the amputated extremity, employing the entire soft tissue of the forearm. ...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2007-1006984

    authors: Schmidt RG,Springfield DS,Dell PC

    更新日期:1987-04-01 00:00:00

  • Reconstruction of a floating thumb with an excess big toe.

    abstract::In a three-year-11-month-old girl, an excess big toe was transferred microsurgically to replace a congenital floating thumb. The reconstructed thumb was evaluated nine years after the transfer. It showed almost normal growth, compared with the contralateral side, and the aesthetic result was excellent. However, the pa...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2007-1006565

    authors: Harashina T,Inoue T,Fujino T,Uchinishi K,Itoh Y

    更新日期:1994-01-01 00:00:00

  • Operative technique to harvest an arterial flap from the posterolateral calf region: how can we elevate a lateral gastrocnemius perforating artery flap safely?

    abstract::The posterior calf region is a useful donor site for skin or composite flaps including muscle and/or nerves. We reported the first clinical use of the lateral gastrocnemius perforating artery flap including a vascularized sural nerve in 2003. This flap was elevated based on a perforator arising from the lateral head o...

    journal_title:Journal of reconstructive microsurgery

    pub_type: 杂志文章

    doi:10.1055/s-2008-1064930

    authors: Kashiwa K,Kobayashi S,Tono H,Ogino K,Kimura H

    更新日期:2008-01-01 00:00:00