Concurrence of anaphylaxis and acute heparin-induced thrombocytopenia in a patient with heparin-induced antibodies.

Abstract:

:We report the occurrence of acute heparin-induced thrombocytopenia in a patient with anaphylaxis that began immediately after an intravenous bolus dose of unfractionated heparin. This case report is the first to document the concurrence of these 2 reactions to heparin. An abrupt fall in platelet count was documented immediately after the anaphylactic response. Study results for antibodies characteristic of heparin-induced thrombocytopenia were positive in 2 assays: serotonin release assay and heparin platelet factor 4 enzyme-linked immunosorbent assay. The patient's antibody was exclusively immunoglobulin G. Any explanation for the relationship between the antibody response observed and the histamine release remains speculative.

journal_name

J Vasc Surg

authors

Hewitt RL,Akers DL,Leissinger CA,Gill JI,Aster RH

doi

10.1016/s0741-5214(98)70146-6

subject

Has Abstract

pub_date

1998-09-01 00:00:00

pages

561-5

issue

3

eissn

0741-5214

issn

1097-6809

pii

S0741521498002699

journal_volume

28

pub_type

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