Abstract:
OBJECTIVE:In the modern healthcare system, rapidly expanding costs/complexity, the growing myriad of treatment options, and exploding information streams that often do not effectively reach the front lines hinder the ability to choose optimal treatment decisions over time. The goal in this paper is to develop a general purpose (non-disease-specific) computational/artificial intelligence (AI) framework to address these challenges. This framework serves two potential functions: (1) a simulation environment for exploring various healthcare policies, payment methodologies, etc., and (2) the basis for clinical artificial intelligence - an AI that can "think like a doctor". METHODS:This approach combines Markov decision processes and dynamic decision networks to learn from clinical data and develop complex plans via simulation of alternative sequential decision paths while capturing the sometimes conflicting, sometimes synergistic interactions of various components in the healthcare system. It can operate in partially observable environments (in the case of missing observations or data) by maintaining belief states about patient health status and functions as an online agent that plans and re-plans as actions are performed and new observations are obtained. This framework was evaluated using real patient data from an electronic health record. RESULTS:The results demonstrate the feasibility of this approach; such an AI framework easily outperforms the current treatment-as-usual (TAU) case-rate/fee-for-service models of healthcare. The cost per unit of outcome change (CPUC) was $189 vs. $497 for AI vs. TAU (where lower is considered optimal) - while at the same time the AI approach could obtain a 30-35% increase in patient outcomes. Tweaking certain AI model parameters could further enhance this advantage, obtaining approximately 50% more improvement (outcome change) for roughly half the costs. CONCLUSION:Given careful design and problem formulation, an AI simulation framework can approximate optimal decisions even in complex and uncertain environments. Future work is described that outlines potential lines of research and integration of machine learning algorithms for personalized medicine.
journal_name
Artif Intell Medjournal_title
Artificial intelligence in medicineauthors
Bennett CC,Hauser Kdoi
10.1016/j.artmed.2012.12.003subject
Has Abstractpub_date
2013-01-01 00:00:00pages
9-19issue
1eissn
0933-3657issn
1873-2860pii
S0933-3657(12)00151-0journal_volume
57pub_type
杂志文章abstract::In a digitally enabled healthcare setting, we posit that an individual's current location is pivotal for supporting many virtual care services-such as tailoring educational content towards an individual's current location, and, hence, current stage in an acute care process; improving activity recognition for supportin...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2020.101931
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:This work presents a system for a simultaneous non-invasive estimate of the blood glucose level (BGL) and the systolic (SBP) and diastolic (DBP) blood pressure, using a photoplethysmograph (PPG) and machine learning techniques. The method is independent of the person whose values are being measured and does n...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2011.05.001
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:Patients who are readmitted to an intensive care unit (ICU) usually have a high risk of mortality and an increased length of stay. ICU readmission risk prediction may help physicians to re-evaluate the patient's physical conditions before patients are discharged and avoid preventable readmissions. ICU readmi...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2018.08.004
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:The Arden Syntax is a knowledge-encoding standard, started in 1989, and now in its 10th revision, maintained by the health level seven (HL7) organization. It has constructs borrowed from several language concepts that were available at that time (mainly the HELP hospital information system and the Regenstrie...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2015.11.003
更新日期:2018-11-01 00:00:00
abstract::Hospital laboratories perform examination tests upon patients, in order to assist medical diagnosis or therapy progress. Planning and scheduling patient requests for examination tests is a complicated problem because it concerns both minimization of patient stay in hospital and maximization of laboratory resources uti...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/s0933-3657(00)00061-0
更新日期:2000-10-01 00:00:00
abstract::In case-based studies, controls are retrospectively assigned to patients in order to permit a statistical evaluation of the study results through a comparison of the main outcome measures for the patient and retrieved control groups. Inappropriate selection of the controls by using false retrieval parameters or a fals...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/s0933-3657(02)00084-2
更新日期:2002-11-01 00:00:00
abstract::During the appointment booking process in out-patient departments, the level of patient satisfaction can be affected by whether or not their preferences can be met, including the choice of physicians and preferred time slot. In addition, because the appointments are sequential, considering future possible requests is ...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2018.02.001
更新日期:2018-04-01 00:00:00
abstract::If our goal in Artificial Intelligence in Medicine (AIM) is to engineer systems health-care providers will both use and, in the process, improve their performance, we must concentrate on the development of causal theories of knowledge and problem solving. One broad direction in pursuing this goal is understanding the ...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章,评审
doi:10.1016/0933-3657(93)90013-s
更新日期:1993-04-01 00:00:00
abstract:OBJECTIVE:This work proposes creating an automatic system to locate and segment the optic nerve head (ONH) in eye fundus photographic images using genetic algorithms. METHODS AND MATERIAL:Domain knowledge is used to create a set of heuristics that guide the various steps involved in the process. Initially, using an ey...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2008.04.005
更新日期:2008-07-01 00:00:00
abstract::The purpose of a clinical trial is to evaluate a new treatment procedure. When medical researchers conduct a trial, they recruit participants with appropriate health problems and medical histories. To select participants, they analyze medical records of the available patients, which has traditionally been a manual pro...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2004.01.017
更新日期:2004-07-01 00:00:00
abstract::Disagreement or inconsistencies in mammographic interpretation motivates utilizing computerized pattern recognition algorithms to aid the assessment of radiographic features. We have studied the potential for using artificial neural networks (ANNs) to analyze interpreted radiographic features from film screen mammogra...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/s0933-3657(98)00040-2
更新日期:1998-11-01 00:00:00
abstract::We introduce a novel approach to couple temporal similarity with spatial neighborhood information. This is achieved by concatenating the K nearest, spatially contiguous neighbors of a pixel time-course (TC) of T time-instances. This produces a new TC of (K+1)T time instances. Depending on how "nearest" is defined, we ...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/s0933-3657(02)00005-2
更新日期:2002-05-01 00:00:00
abstract::Over the years, there has been growing interest in using machine learning techniques for biomedical data processing. When tackling these tasks, one needs to bear in mind that biomedical data depends on a variety of characteristics, such as demographic aspects (age, gender, etc.) or the acquisition technology, which mi...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2020.101804
更新日期:2020-03-01 00:00:00
abstract:CONTEXT:Temporal information plays a crucial role in medicine, so that in medical informatics there is an increasing awareness that suitable database approaches are needed to store and support it. Specifically, a great amount of clinical data (e.g., therapeutic data) are periodically repeated. Although an explicit trea...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2012.03.002
更新日期:2012-07-01 00:00:00
abstract::We present a new stochastic learning algorithm and first results of computational experiments on fragments of liver CT images. The algorithm is designed to compute a depth-three threshold circuit, where the first layer is calculated by an extension of the Perceptron algorithm by a special type of simulated annealing. ...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/s0933-3657(00)00112-3
更新日期:2001-06-01 00:00:00
abstract:OBJECTIVE:The objective of the present work was to develop and compare methods for automatic detection of bilateral sleep spindles. METHODS AND MATERIALS:All-night sleep electroencephalographic (EEG) recordings of 12 healthy subjects with a median age of 40 years were studied. The data contained 6043 visually scored b...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2007.04.003
更新日期:2007-07-01 00:00:00
abstract::Knowledge discovery from omics data has become a common goal of current approaches to personalised cancer medicine and understanding cancer genotype and phenotype. However, high-throughput biomedical datasets are characterised by high dimensionality and relatively small sample sizes with small signal-to-noise ratios. ...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2020.101821
更新日期:2020-04-01 00:00:00
abstract::Quality of life of patients with Parkinson's disease degrades significantly with disease progression. This paper presents a step towards personalized management of Parkinson's disease patients, based on discovering groups of similar patients. Similarity is based on patients' medical conditions and changes in the presc...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2018.04.010
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVES:In the presurgical analysis for drug-resistant focal epilepsies, the definition of the epileptogenic zone, which is the cortical area where ictal discharges originate, is usually carried out by using clinical, electrophysiological and neuroimaging data analysis. Clinical evaluation is based on the visual det...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2014.03.001
更新日期:2014-06-01 00:00:00
abstract::Melanoma is the most dangerous skin cancer and early diagnosis is the key factor in its successful treatment. Well-trained dermatologists reach a diagnosis via visual inspection, and reach sensitivity and specificity levels of about 80%. Several computerised diagnostic systems were reported in the literature using dif...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/s0933-3657(02)00087-8
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:A major focus in computational system biology research is defining organizing principles that govern complex biological network formation and evolution. The task is considered a major challenge because network behavior and function prediction requires the identification of functionally and statistically impor...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2007.07.006
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVE:The aim of this paper is to provide an improved method for solving the so-called dynamic patient admission scheduling (DPAS) problem. This is a complex scheduling problem that involves assigning a set of patients to hospital beds over a given time horizon in such a way that several quality measures reflecting...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2016.10.002
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:We provide a survey of recent advances in biomedical image analysis and classification from emergent imaging modalities such as terahertz (THz) pulse imaging (TPI) and dynamic contrast-enhanced magnetic resonance images (DCE-MRIs) and identification of their underlining commonalities. METHODS:Both time and f...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2016.01.005
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVE:To assess whether a user-centred prototype clinical decision support system (CDSS) providing patient-specific advice better supports healthcare practitioners in terms of (a) types of usability problems detected and (b) effective and efficient retrieval of childhood cancer survivor's follow-up screening proced...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2013.04.004
更新日期:2013-09-01 00:00:00
abstract::Computer-aided detection (CADe) systems play a crucial role in pulmonary nodule detection via chest radiographs (CXRs). A two-stage CADe scheme usually includes nodule candidate detection and false positive reduction. A pure deep learning model, such as faster region convolutional neural network (faster R-CNN), has be...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2020.101881
更新日期:2020-07-01 00:00:00
abstract::HepatoConsult is a publicly available knowledge-based second opinion and documentation system aiding in the diagnosis of liver diseases. The positive results of a prospective diagnostic evaluation study encouraged its use in clinical routine, although the available hardware infrastructure was not optimal. The comments...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/s0933-3657(01)00104-x
更新日期:2002-03-01 00:00:00
abstract:OBJECTIVES:Access to the world wide web and multimedia content is an important aspect of life. We present a web browser and a multimedia user interface adapted for control with a brain-computer interface (BCI) which can be used by severely motor impaired persons. METHODS:The web browser dynamically determines the most...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2014.12.001
更新日期:2015-01-01 00:00:00
abstract::The decompressive laminectomy is a common operation for treatment of lumbar spinal stenosis. The tools for grinding and drilling are used for fenestration and internal fixation, respectively. The state recognition is one of the main technologies in robot-assisted surgery, especially in tele-surgery, because surgeons h...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2019.101763
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:The radiology report is the most important source of clinical imaging information. It documents critical information about the patient's health and the radiologist's interpretation of medical findings. It also communicates information to the referring physicians and records that information for future clinic...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章,多中心研究
doi:10.1016/j.artmed.2015.09.007
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVES:Brain-computer interfaces (BCIs) are no longer only used by healthy participants under controlled conditions in laboratory environments, but also by patients and end-users, controlling applications in their homes or clinics, without the BCI experts around. But are the technology and the field mature enough f...
journal_title:Artificial intelligence in medicine
pub_type: 杂志文章
doi:10.1016/j.artmed.2013.08.004
更新日期:2013-10-01 00:00:00