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Interactions at the blood/material interface.

Abstract：

:The complex interactions occurring at the blood/material interface of implanted blood-contacting biomaterials largely determine the clinical efficacy of small diameter vascular grafts. Physical characteristics of the material such as chemical composition, electrical charge, surface texture, elastic modulus, and porosity all affect many responses at the interfaces with blood, surrounding tissues, and adjacent artery. Some responses begin instantaneously (deposition of plasma proteins and platelets) while other reactions are somewhat delayed (deposition of leukocytes and monocytes, and migration of endothelial cells and smooth muscle cells). Each of these elements may become activated and release bioactive substances which further affect the behavior of the other entities in this complex and dynamic microenvironment. It is precisely these tissue reactions that regulate thrombogenicity and the development of pseudointimal hyperplasia.

journal_name

Ann Vasc Surg

journal_title

Annals of vascular surgery

authors

Greisler HP

doi

10.1007/BF02042699

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

98-103

issue

1

eissn

0890-5096

issn

1615-5947

pii

S0890-5096(06)60521-9

journal_volume

4

pub_type

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