Abstract：
BACKGROUND:High glucose (HG)-induced endothelial dysfunction is a common pathologic process of vascular disease in patients with diabetes. HoxA9EC is a transcriptional regulator of genes involved in the stabilization of endothelial function. We sought to elucidate the effect of HG on HoxA9EC expression in human umbilical venous endothelial cells (HUVECs), and the potential role of HoxA9EC in antagonizing HG-induced endothelial dysfunction. METHODS:HUVECs treated with HoxA9EC transfection were cultured in media with HG, and those treated either by HG or HoxA9EC knockdown were incubated without HG. These cells were then subjected to experiments including mRNA expression analysis for eNOS, VEGFR-2, and HoxA9EC by quantitative RT-PCR; protein level analysis for eNOS, VEGFR-2, and HoxA9EC by Western blot; detection of nitric oxide (NO) concentration; and migration assay. RESULTS:Expression levels of eNOS, VEGFR-2, and HoxA9EC, as well as cell migration and NO concentration, decreased rapidly in HUVECs with HoxA9EC knockdown or under HG conditions. Overexpression of HoxA9EC significantly repaired expression of eNOS and VEGFR-2, cell migration, and NO release of endothelial cells under HG conditions. CONCLUSIONS:Inhibition of HoxA9EC induced by HG contributed to endothelial cell dysfunction, which could be rescued by augmentation of HoxA9EC under HG conditions.
journal_name
Ann Vasc Surgjournal_title
Annals of vascular surgeryauthors
Zhang N,Gong L,Zhang H,Cao Cdoi
10.1016/j.avsg.2012.05.011subject
Has Abstractpub_date
2012-10-01 00:00:00pages
1002-10issue
7eissn
0890-5096issn
1615-5947pii
S0890-5096(12)00333-0journal_volume
26pub_type
杂志文章abstract：BACKGROUND:Endovascular treatment of aortoiliac occlusive disease (AIOD) involving the aortic bifurcation is challenging. The gold standard is open surgery with patency rates up to 90% at 5 years, but has considerable morbidity and mortality. The kissing stent (KS) technique was introduced as an alternative. The goal o...
journal_title：Annals of vascular surgery
pub_type： 杂志文章,评审
doi：10.1016/j.avsg.2017.01.009
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:The aim of this study was to report the feasibility and outcomes with the endovascular treatment of spontaneous internal carotid artery dissections (ICADs) using a proximal embolic protection device (EPD). METHODS:This is a retrospective analysis of patients treated for spontaneous symptomatic ICAD using a ...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2019.12.019
更新日期：2020-07-01 00:00:00
abstract：BACKGROUND:The aim of this study was to report the results of percutaneous endovascular aortic aneurysm repair (PEVAR) using the superficial femoral artery (SFA) for large bore vessel access. METHODS:We reviewed all PEVAR procedures at our institution over an 18-month period, identifying all patients who underwent PEV...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2016.06.018
更新日期：2017-01-01 00:00:00
abstract：:Rarely, internal carotid artery (ICA) patency is maintained above a common carotid artery occlusion (CCAO) through collateral flow of the ipsilateral external carotid artery or an aberrant ICA branch. Several small series report excellent results of ICA revascularization in relieving cerebral ischemic symptoms in thes...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1007/s100169900223
更新日期：1999-01-01 00:00:00
abstract：:Sixty-two first episodes of aortofemoral (eight patients) or aortobifemoral (42 patients) bypass thrombosis were operated upon in 50 patients between 1980 and 1985. There were 47 men and three women whose mean age was 58 years. Retrograde thrombectomy through the distal anastomosis was achieved in all cases by using e...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1007/BF02021771
更新日期：1991-01-01 00:00:00
abstract：BACKGROUND:Crossed-fused renal ectopia is a rare anomaly that poses a therapeutic challenge in the management of abdominal aortic aneurysms (AAAs). Such challenges include preservation of renal blood flow in the setting of multiple aberrant renal arteries and ureteral anomalies. Several surgical approaches to this dile...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2011.05.016
更新日期：2011-10-01 00:00:00
abstract：:Endovascular repair of peripheral arterial lesions was performed in 10 patients including two iliac aneurysms, two iliac anastomotic pseudoaneurysms, one subclavian pseudoaneurysm, one axillary anastomotic disruption, two prosthetic pseudoaneurysms, and two posttraumatic arteriovenous (AV) fistulas. The indications fo...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1007/s100169900043
更新日期：1997-05-01 00:00:00
abstract：BACKGROUND:Our goal was to analyze the incidence and risk factors for 30-day postdischarge mortality in patients with vascular disease undergoing major lower extremity amputation. METHODS:We queried the American College of Surgeons National Surgery Quality Improvement Program data set from the years 2005 to 2009 for a...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2011.05.012
更新日期：2012-02-01 00:00:00
abstract：BACKGROUND:The possibility of predicting severe compartment syndrome using simple biochemical parameters was evaluated in a single-center study of 55 patients who presented with acute femoral embolism and who were treated with open surgical embolectomy. METHODS:Parameters related to tissue damage and oxidative metabol...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2012.12.006
更新日期：2014-01-01 00:00:00
abstract：:We present a unique case of listeria-infected pseudoaneurysm of the superficial femoral artery. Listeria monocytogenes, a gram positive, intracellular bacterium, is widespread in the environment. The manifestation of infection in humans ranges from mild gastroenteritis to life-threatening listeriosis. The incidence in...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2015.09.013
更新日期：2016-02-01 00:00:00
abstract：:In the past 2 decades, varicose veins surgery went through a great turbulence and various innovations. A number of new techniques have been introduced with a goal to increase the success rate, reduce the periprocedural complications and, overall, to improve patients' quality of life. The latest of them, named cyanoacr...
journal_title：Annals of vascular surgery
pub_type： 杂志文章,评审
doi：10.1016/j.avsg.2018.06.009
更新日期：2019-02-01 00:00:00
abstract：:Weakness in the musculotendinous barrier of the abdominal wall leads to inguinal herniation. Fiber degeneration by increased metabolism has been described recently as a causative factor. In previous investigations heightened elastase was detected in abdominal aneurysms. In order to investigate a possible relationship ...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1007/BF02042733
更新日期：1992-03-01 00:00:00
abstract：BACKGROUND:The objective of the study was to compare the outcomes of externally supported polytetrafluoroethylene (PTFE) grafts and femoral vein as conduits for femorofemoral crossover grafts. METHODS:This is a retrospective review of consecutive femorofemoral crossover grafts at our institution between January 2005 a...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2018.03.024
更新日期：2018-10-01 00:00:00
abstract：:We report a case of a traumatically-induced embolus from a thrombosed PTFE vascular access graft in a patient who had undergone a successful cadaveric renal transplant. Although usually thought to be without subsequent sequelae, thrombosed PTFE grafts can be a source of emboli to the hand in active young patients. Dia...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1007/BF02001376
更新日期：1990-03-01 00:00:00
abstract：:We present a case of brachial artery mycotic aneurysm caused by methicillin-resistant Staphylococcus epidermidis in a patient with infective endocarditis. A 66-year-old woman suffered two transient ischemic attacks over an 8-week period secondary to septic emboli from mitral valve endocarditis. Following valve replace...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1007/s10016-006-9065-4
更新日期：2006-09-01 00:00:00
abstract：:Our case of primary leiomyosarcomas involved retrohepatic, suprarenal, and infrarenal inferior vena cava (IVC). Preoperative phlebography proved that there was adequate collateral circulation formed, which allowed us to achieve en bloc resection including segment I and II IVC without either extracorporeal circulation ...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2009.12.015
更新日期：2010-08-01 00:00:00
abstract：:We report a reoperation case of a ruptured infectious aortic arch pseudoaneurysm, which was stabilized with thoracic endovascular aortic repair and snorkel bypass of the innominate artery (IA) and the left common carotid artery (LCCA). A 57-year-old Chinese woman with multiple comorbidities and previous open repair fo...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2016.09.035
更新日期：2017-05-01 00:00:00
abstract：:The most common anatomical variation of the superficial femoral artery (SFA) is hypoplasia or aplasia, associated with persistent sciatic artery. Duplication of SFA remains uncommon. We report a case of SFA duplication discovered on an angiogram performed for critical limb ischemia, in an 80-year-old man. ...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2009.09.010
更新日期：2010-04-01 00:00:00
abstract：:Despite major advances in pharmacologic and endovascular therapies, acute limb ischemia (ALI) continues to result in significant morbidity and mortality. The incidence of ALI may be as high as 13-17 cases per 100,000 people per year, with mortality rates approaching 18% in some series. This review will address the con...
journal_title：Annals of vascular surgery
pub_type： 杂志文章,评审
doi：10.1016/j.avsg.2011.05.017
更新日期：2012-01-01 00:00:00
abstract：:Carotidynia is a term that is best defined by neck pain associated with tenderness over the carotid artery. The differential diagnosis of this entity is broad and includes vascular disorders such as carotid dissection, aneurysm, occlusion, and arteritis. We describe the first reported case of carotidynia caused by sep...
journal_title：Annals of vascular surgery
pub_type： 杂志文章,评审
doi：10.1007/s10016-001-0402-3
更新日期：2003-03-01 00:00:00
abstract：:Acute occlusion of the visceral arteries is a threatening complication following branched endovascular aortic repair (EVAR). Its prompt diagnosis and treatment are mandatory to restore renal function. Several techniques have been used to manage this complication. We report 2 clinical cases of patients, previously trea...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2017.07.015
更新日期：2017-11-01 00:00:00
abstract：BACKGROUND:The aim of this study was to review the efficacy of the Flixene™ (Atrium™, Hudson, NH, USA) hemodialysis arterio-venous graft (AVG) in a multiethnic Asian cohort of patients with end-stage renal failure (ESRF). Primary outcome was graft primary patency rate and secondary end points included graft usability, ...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2020.11.029
更新日期：2020-12-26 00:00:00
abstract：:Between October 1990 and June 2001, 121 patients underwent surgery for thoracoabdominal aortic aneurysm (TAAA)-99 procedures were elective and 22 were for ruptured aneurysms. Between October 1990 and September 1997, the clamp-and-go technique was used for all aneurysms (43 patients), and from October 1997, clamp-and-g...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1007/s10016-001-0181-x
更新日期：2002-09-01 00:00:00
abstract：BACKGROUND:Hepatocellular carcinoma (HCC) with tumor thrombus (TT) in hepatic vein, inferior vena cava (IVC), and right atrium (RA) portends a poor prognosis because of intravascular extension leading to rapid distal metastases. En bloc resection of cavoatrial TT without the use of cardiopulmonary bypass (CPB) is chall...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2014.02.021
更新日期：2014-08-01 00:00:00
abstract：:Certain patients have atherosclerosis in both aortoiliac and femoropopliteal segments of the arterial tree and thus do not have a good result from reconstruction of the aortoiliac segment. No method has been developed to identify these patients and we do not know whether, by combining a femoropopliteal bypass with an ...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/S0890-5096(06)60730-9
更新日期：1987-05-01 00:00:00
abstract：:Secondary to central venous stenosis or thrombosis, alternate sites for permanent hemodialysis need to be explored. The authors' experience with the greater saphenous vein to common femoral artery loop arteriovenous fistula (GSV-CFA AVF) is presented. A retrospective review was performed of 4 women and 3 men with a me...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1007/s10016-004-0016-7
更新日期：2004-03-01 00:00:00
abstract：:Carotid artery angioplasty and stenting is gaining popularity, yet the natural history and optimal treatment for recurrent stenoses within stents are not known. Recurrent stenosis rates are not well characterized, with rates between 0 and 33% reported within the first year. Treatment of these lesions with repeat angio...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1007/s10016-001-0279-1
更新日期：2002-09-01 00:00:00
abstract：BACKGROUND:The purpose of this study was to quantify and evaluate the expression response of miRNA-191 and miRNA-455-3p endovascular repair of abdominal aortic aneurysm (AAA) based in whole blood samples. METHODS:This report describes a prospective study of a single center of 30 patients with AAA who underwent endovas...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2018.01.086
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:Limited guidelines for the treatment and management of acute and chronic iliocaval thrombosis are published in the literature. The purpose of this report is to present global iliocaval stent reconstruction practices by interventionalists. METHODS:A 45-question survey focusing on iliocaval stent reconstructi...
journal_title：Annals of vascular surgery
pub_type： 杂志文章,多中心研究
doi：10.1016/j.avsg.2018.01.076
更新日期：2018-05-01 00:00:00
abstract：:Reported patency rates for paramalleolar bypass grafts have varied widely. To determine factors predictive of outcome, we reviewed our experience with 80 consecutive paramalleolar reconstructions in 68 patients performed between December 1986 and May 1995. All procedures were performed for critical limb ischemia defin...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1007/BF02286779
更新日期：1996-07-01 00:00:00
