Abstract:
INTRODUCTION:Progesterone receptor (PR) agonists (progestins) and antagonists are developed for female contraceptives. However, non-contraceptive applications of newer progestins and PR modulators are being given more attention. AREAS COVERED:The newer PR agonists including drospirenone, nomegestrol, trimegestone, dienogest and nestorone are being evaluated as contraceptives with health benefits because of their unique pharmacological properties. The selective PR modulators (SPRM; PR antagonists with PR agonistic properties) are under development not only for emergency contraception but also for other health benefits such as the treatment of endometritis and leiomyoma. After searching the literature from PubMed, clinicaltrials.gov and patent database, this review focuses on the effects and mechanisms of these progestins, and SPRMs as contraceptives with other health benefits. EXPERT OPINION:PR agonists and antagonists that have novel properties may generate better contraceptive effects with other health benefits.
journal_name
Expert Opin Investig Drugsjournal_title
Expert opinion on investigational drugsauthors
Su Y,Lian QQ,Ge RSdoi
10.1517/13543784.2012.642368subject
Has Abstractpub_date
2012-01-01 00:00:00pages
83-90issue
1eissn
1354-3784issn
1744-7658journal_volume
21pub_type
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