Abstract:
:Langerhans cell histiocytosis (LCH) is rare in adults, and only a subset of these patients suffers from central nervous system (CNS) involvement. Hence, evidence-based treatment recommendations are lacking. A case of a 20-year-old student with multisystem LCH and extensive CNS involvement is described, who showed a durable response to 2-chlorodeoxyadenosine after prior therapies with the tyrosine kinase inhibitors sorafenib and imatinib. In accordance to the experiences provided by other case series, which are reviewed herein, 2-chlorodeoxyadenosine can be considered an effective and safe option for adult LCH with CNS involvement.
journal_name
Hematol Oncoljournal_title
Hematological oncologyauthors
Baumann M,Cerny T,Sommacal A,Koeberle Ddoi
10.1002/hon.1005subject
Has Abstractpub_date
2012-06-01 00:00:00pages
101-4issue
2eissn
0278-0232issn
1099-1069journal_volume
30pub_type
杂志文章abstract::Fourteen patients with poor-risk acute myelogenous leukaemia (AML) and five patients with accelerated phase/blast crisis chronic myeloid leukaemia (CML) were treated with 3 days of oral idarubicin (25 mg/m2/day). No complete remissions or return to chronic phase CML were observed. A fall in the peripheral blast count ...
journal_title:Hematological oncology
pub_type: 杂志文章
doi:10.1002/hon.2900070605
更新日期:1989-11-01 00:00:00
abstract::The aim of the study was to describe the clinical and epidemiological characteristics, anatomic and histologic distribution, and treatment results of extranodal lymphomas (ENLs), diagnosed and treated in the public health system in Chile. We included patients with ENL diagnosed from 1998 to 2014, in 17 cancer centers,...
journal_title:Hematological oncology
pub_type: 杂志文章,多中心研究
doi:10.1002/hon.2547
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abstract::One hundred and fifteen previously untreated adults aged over 60 years were referred to St Bartholomew's Hospital between 1978 and 1986 for management of acute myeloid leukemia (AML). Twenty-seven patients received symptomatic or palliative treatment only because combination chemotherapy was considered inappropriate. ...
journal_title:Hematological oncology
pub_type: 杂志文章
doi:10.1002/hon.2900080103
更新日期:1990-01-01 00:00:00
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journal_title:Hematological oncology
pub_type: 杂志文章,meta分析,评审
doi:10.1002/hon.2152
更新日期:2015-09-01 00:00:00
abstract::Fungal infection is a serious complication in immunocompromised patients, especially those with neutropenia. Itraconazole (ITZ) is expected to be an effective prophylactic agent for fungal infection because it has more activity against Aspergillus species than fluconazole and it is less toxic than amphotericin-B. Howe...
journal_title:Hematological oncology
pub_type: 临床试验,杂志文章
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更新日期:1998-03-01 00:00:00
abstract::The acquired clonal disorder Polycythaemia Vera leads to increased erythropoiesis, myelopoiesis and megakaryopoeisis. These anomalies result in an increased incidence of thromboembolic events, transformation to acute leukaemia and myelofibrosis. Treatments which aim to reduce the event rate may increase anaemia but ma...
journal_title:Hematological oncology
pub_type: 杂志文章,评审
doi:10.1002/hon.809
更新日期:2007-06-01 00:00:00
abstract::Mucosa-associated lymphatic tissue (MALT) lymphoma of the breast is an extremely rare disease; its pathogenesis is not clear because of the rarity of disease, and the best diagnostic method has yet to be established. The metabolic behavior of this lymphoma is not still clear because only a few case reports are present...
journal_title:Hematological oncology
pub_type:
doi:10.1002/hon.2376
更新日期:2017-12-01 00:00:00
abstract::Pediatric-type follicular lymphoma (PTFL), pediatric nodal marginal zone lymphoma (pnMZL), and large B-cell lymphoma (LBCL) with IRF4 rearrangement have been introduced into the current World Health Organization (WHO) classification. They account for 5% to 10% of mature B-cell lymphomas in children and adolescents. Bo...
journal_title:Hematological oncology
pub_type: 杂志文章,评审
doi:10.1002/hon.2585
更新日期:2019-06-01 00:00:00
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journal_title:Hematological oncology
pub_type: 临床试验,杂志文章
doi:10.1002/hon.2900100604
更新日期:1992-11-01 00:00:00
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journal_title:Hematological oncology
pub_type: 杂志文章
doi:10.1002/hon.2900080207
更新日期:1990-03-01 00:00:00
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journal_title:Hematological oncology
pub_type: 杂志文章
doi:10.1002/hon.2900100303
更新日期:1992-05-01 00:00:00
abstract::Continuous administration of amphotericin B deoxycholate over 24 hours (24 h-D-AmB) is better tolerated than rapid infusions. However, toxicity and outcome have not been assessed in a homogenous patient population with acute myeloid leukaemia (AML). We retrospectively analysed renal function and outcome in all adult p...
journal_title:Hematological oncology
pub_type: 杂志文章
doi:10.1002/hon.2500
更新日期:2018-04-01 00:00:00
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journal_title:Hematological oncology
pub_type: 杂志文章
doi:10.1002/(sici)1099-1069(199903)17:1<31::aid-hon636
更新日期:1999-03-01 00:00:00
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journal_title:Hematological oncology
pub_type: 杂志文章
doi:10.1002/hon.2116
更新日期:2014-09-01 00:00:00
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journal_title:Hematological oncology
pub_type: 杂志文章
doi:10.1002/hon.822
更新日期:2007-09-01 00:00:00
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journal_title:Hematological oncology
pub_type: 杂志文章,评审
doi:10.1002/hon.2711
更新日期:2020-08-01 00:00:00
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journal_title:Hematological oncology
pub_type: 杂志文章
doi:10.1002/hon.2900120304
更新日期:1994-05-01 00:00:00
abstract::Prognoses of persons with chronic lymphocytic leukemia (CLL) including time-to-therapy (TTT) and survival is heterogeneous. Risk factors and predictive scoring systems are mostly developed in persons of predominately European descent with CLL. Whether these systems accurately predict TTT and survival of Han Chinese wi...
journal_title:Hematological oncology
pub_type: 杂志文章
doi:10.1002/hon.2520
更新日期:2018-10-01 00:00:00
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journal_title:Hematological oncology
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:1991-07-01 00:00:00
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journal_title:Hematological oncology
pub_type: 杂志文章
doi:10.1002/hon.2483
更新日期:2018-02-01 00:00:00
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journal_title:Hematological oncology
pub_type: 杂志文章
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journal_title:Hematological oncology
pub_type: 杂志文章,评审
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更新日期:2020-12-01 00:00:00
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journal_title:Hematological oncology
pub_type: 杂志文章
doi:10.1002/hon.2900040303
更新日期:1986-07-01 00:00:00
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journal_title:Hematological oncology
pub_type: 杂志文章
doi:10.1002/hon.2900070503
更新日期:1989-09-01 00:00:00
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journal_title:Hematological oncology
pub_type: 杂志文章,评审
doi:10.1002/hon.2676
更新日期:2020-02-01 00:00:00
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journal_title:Hematological oncology
pub_type: 杂志文章
doi:10.1002/hon.2900090608
更新日期:1991-11-01 00:00:00
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journal_title:Hematological oncology
pub_type: 杂志文章
doi:10.1002/hon.733
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journal_title:Hematological oncology
pub_type: 杂志文章,评审
doi:10.1002/hon.2900070202
更新日期:1989-03-01 00:00:00
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journal_title:Hematological oncology
pub_type: 杂志文章
doi:10.1002/hon.2900030107
更新日期:1985-01-01 00:00:00
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journal_title:Hematological oncology
pub_type: 杂志文章,meta分析
doi:10.1002/hon.2173
更新日期:2015-12-01 00:00:00